Catalog No.
YHB43201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Cys394
Predicted molecular weight
47.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94776
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PID, Metastasis-associated 1-like 1, MTA2, p53 target protein in deacetylase complex, MTA1L1, Metastasis-associated protein MTA2, MTA1-L1 protein
Endothelial miR-34a deletion guards against aneurysm development despite endothelial dysfunction., PMID:40139409
MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression., PMID:39248711
A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin., PMID:38678016
lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation., PMID:38649186
CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3., PMID:38474064
Loss of MTA2-mediated downregulation of PTK7 inhibits hepatocellular carcinoma metastasis progression by modulating the FAK-MMP7 axis., PMID:38050825
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts., PMID:37898641
BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells., PMID:37737560
Expression and Significance of MTA2 and CPNE1 in Cervical Squamous Cell Carcinoma., PMID:37399268
Prognostic, Immunological, and Mutational Analysis of MTA2 in Pan-Cancer and Drug Screening for Hepatocellular Carcinoma., PMID:37371463
Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss., PMID:36913304
Characterization of the nuclear import of the human CHD4-NuRD complex., PMID:36861403
MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5., PMID:36741260
A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells., PMID:36575438
Serum proteomic profiling reveals MTA2 and AGO2 as potential prognostic biomarkers associated with disease activity and adverse outcomes in multiple myeloma., PMID:36454786
lncRNA PCAT1 might coordinate ZNF217 to promote CRC adhesion and invasion through regulating MTA2/MTA3/Snai1/E-cadherin signaling., PMID:35809308
NuRD complex recruitment to Thpok mediates CD4+ T cell lineage differentiation., PMID:35687698
CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer., PMID:35484118
Melatonin combined with sorafenib synergistically inhibit the invasive ability through targeting metastasis-associated protein 2 expression in human renal cancer cells., PMID:35465276
Discovery of Genes that Modulate Flavivirus Replication in an Interferon-Dependent Manner., PMID:34599939
Long Noncoding RNA TTC39A-AS1 Promotes Breast Cancer Tumorigenicity by Sponging MicroRNA-483-3p and Thereby Upregulating MTA2., PMID:34488224
MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress., PMID:34280886
MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis., PMID:33958583
MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells., PMID:33795651
Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells., PMID:33744762
Clinical Significance and Oncogenic Activity of GRWD1 Overexpression in the Development of Colon Carcinoma., PMID:33688204
Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype., PMID:33420368
MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E-Twist feedback loop., PMID:33340431
SNHG5 inhibits the progression of EMT through the ubiquitin-degradation of MTA2 in oesophageal cancer., PMID:33095847
An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway., PMID:32944400
Circular RNA circ-NCOR2 accelerates papillary thyroid cancer progression by sponging miR-516a-5p to upregulate metastasis-associated protein 2 expression., PMID:32940102
Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation., PMID:32816854
An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis., PMID:32512502
Transcriptional Suppression of miR-7 by MTA2 Induces Sp1-Mediated KLK10 Expression and Metastasis of Cervical Cancer., PMID:32402941
LncRNA HOTAIR promotes the invasion and metastasis of oral squamous cell carcinoma through metastasis-associated gene 2., PMID:31995261
Structure Validation of G-Rich RNAs in Noncoding Regions of the Human Genome., PMID:31943589
Metastasis-associated protein 2 regulates human hepatocellular carcinoma metastasis progression through modulating p38MAPK/MMP2 pathways., PMID:31777601
MTA2 as a Potential Biomarker and Its Involvement in Metastatic Progression of Human Renal Cancer by miR-133b Targeting MMP-9., PMID:31771219
New prognostic markers revealed by RNA-Seq transcriptome analysis after MYC silencing in a metastatic gastric cancer cell line., PMID:31645899
The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD., PMID:31462557
MicroRNA-589 serves as a tumor suppressor microRNA through directly targeting metastasis-associated protein 2 in breast cancer., PMID:31452724
LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α., PMID:31410216
Repression of metastasis-associated protein 2 for inhibiting metastasis of human oral cancer cells by promoting the p-cofilin-1/ LC3-II expression., PMID:31359510
MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition., PMID:31291582
Mitogenome types of two Lentinula edodes sensu lato populations in China., PMID:31263159
MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway., PMID:31128910
The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment., PMID:31036553
The stoichiometry and interactome of the Nucleosome Remodeling and Deacetylase (NuRD) complex are conserved across multiple cell lines., PMID:30828972
MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity., PMID:30814496
For research use only. Not for human or drug use.
