Catalog No.
YHB40701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu321-Lys482
Predicted molecular weight
20.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O76074
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CGB-PDE, cGMP-specific 3',5'-cyclic phosphodiesterase, PDE5A, PDE5, cGMP-binding cGMP-specific phosphodiesterase
Quality over quantity: how to get the best results when using docking for repurposing., PMID:40491848
Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity., PMID:40322029
Vascular remodeling in arteriovenous fistula treated with PDE5A inhibitors., PMID:40300852
Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity., PMID:40204283
Phosphodiesterase 5 inactivation in vascular smooth muscle cells aggravates aortic aneurysm and dissection., PMID:40145405
Genetically Proxied Phosphodiesterase Type 5 (PDE5) Inhibition and Risk of Dementia: A Drug Target Mendelian Randomization Study., PMID:39951190
Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m., PMID:39944919
Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer., PMID:39875498
Proteins Involved in Endothelial Function and Inflammation Are Implicated in Cerebral Small Vessel Disease., PMID:39818967
Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum., PMID:39733958
Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking., PMID:39733639
Investigating the Optimal Membrane-Based Separation of Cynaroside From Peony Seed Meals and Assessing Its Biomedical Implications., PMID:39723038
Exploring the Therapeutic Potential of 8-Prenyldaidzein: A Comprehensive Study of its Multi-Target Efficacy in Alzheimer's Disease., PMID:39716790
Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia., PMID:39695100
Discovery and Optimization of Dihydroquinolin-2(1H)-ones as Novel Highly Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension., PMID:39636241
Downregulation of miR-214 promotes dilated Cardiomyopathy Progression through PDE5A-Mediated cGMP regulation., PMID:39543318
Exploring the oncogenic role of RGS19 in bladder cancer progression and prognosis., PMID:39481225
Phosphodiesterase 5 and its inhibitors with ischaemic heart disease: a Mendelian randomization analysis and a real-world study., PMID:39424597
Computational analysis of natural compounds as potential phosphodiesterase type 5A inhibitors., PMID:39405778
Measurement of PDE5 concentration in human serum: proof-of-concept and validation of methodology in control and prostate cancer patients., PMID:39352630
miR-30d Attenuates Pulmonary Arterial Hypertension via Targeting MTDH and PDE5A and Modulates the Beneficial Effect of Sildenafil., PMID:39206778
RUNX1 isoforms regulate RUNX1 and target genes differentially in platelets-megakaryocytes: association with clinical cardiovascular events., PMID:39181539
Putative Pharmacological Depression and Anxiety-Related Targets of Calcitriol Explored by Network Pharmacology and Molecular Docking., PMID:39065743
Potential drug targets for tumors identified through Mendelian randomization analysis., PMID:38762700
Phosphodiesterase 5A regulates the vomeronasal pump in mice., PMID:38738564
Fetal sex and the relative reactivity of human umbilical vein and arteries are key determinants in potential beneficial effects of phosphodiesterase inhibitors., PMID:38695358
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1., PMID:38658954
Identification of Critical Genes Differentiating Stable and Unstable Atherosclerotic Plaques: A Bioinformatic and Computational Analysis., PMID:38639275
Genetic insight into putative causes of xanthelasma palpebrarum: a Mendelian randomization study., PMID:38601164
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy., PMID:38565536
Hsa_circ_0092355 Accelerates Papillary Thyroid Cancer Progression by Regulating the miR-543/PDE5A Pathway., PMID:38286403
Increased cAMP-PKA signaling pathway activation is involved in up-regulation of CTLA-4 expression in CD4+ T cells in acute SIVmac239-infected Chinese rhesus macaques., PMID:38244614
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes., PMID:38185350
Metabolism-Related Prognostic Biomarkers, Purine Metabolism and Anti-Tumor Immunity in Colon Adenocarcinoma., PMID:38179743
Ent-labdane-type diterpene glycosides obtained from Rubus chingii Hu and their inhibitory effects on PDE5A activity., PMID:38135092
Pde5 Inhibition Reduced Blood Pressure and Alleviated Target Organ Damage in Chronic Intermittent Hypoxia., PMID:38030140
Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies., PMID:37887031
No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response., PMID:37743723
MicroRNA-1 protects the endothelium in acute lung injury., PMID:37737266
Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study., PMID:37605207
Identification of selective inhibitors for phosphodiesterase 5A using e-pharmacophore modelling and large-scale virtual screening-based structure guided drug discovery approaches., PMID:37545162
Development of cancer-associated fibroblast-related gene signature for predicting the survival and immunotherapy response in lung adenocarcinoma., PMID:37280069
Analysis of hsa-miR-19a-3p and hsa-miR-19b-3p modulation and phosphodiesterase type 5 expression in the vaginal epithelium of premenopausal women with genital arousal disorder., PMID:37185899
Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity., PMID:37096968
Investigation of shared genes and regulatory mechanisms associated with coronavirus disease 2019 and ischemic stroke., PMID:37090981
IncRNA XIST Stimulates Papillary Thyroid Cancer Development through the miR-330-3p/PDE5A Axis., PMID:37017666
Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes., PMID:36754339
LncRNA ARAP1-AS1 targets miR-516b-5p/PDE5A axis to facilitate the progression of thyroid cancer., PMID:36730555
Phosphodiesterase 5a Signalling in Skeletal Muscle Pathophysiology., PMID:36614143
Co-expression of soluble guanylyl cyclase subunits and PDE5A shRNA to elevate cellular cGMP level: A potential gene therapy for myocardial cell death., PMID:36442224
For research use only. Not for human or drug use.
