Catalog No.
YHB28701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser45-Asp356
Predicted molecular weight
38.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75689
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CENTA1, Centaurin-alpha-1, ADAP1, Arf-GAP with dual PH domain-containing protein 1, Cnt-a1, Putative MAPK-activating protein PM25
Loss of ADAP1/CentA1 Protects Against Autoimmune Demyelination., PMID:40326762
Establishment and characterization of adap1-deficient zebrafish., PMID:40088134
Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies., PMID:38682696
Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study., PMID:38038215
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries., PMID:37156999
Oncogenic fusion transcript analysis identified ADAP1-NOC4L, potentially associated with metastatic colorectal cancer., PMID:35702822
Molecular characterization of vascular intestinal obstruction using whole-exome sequencing., PMID:35571423
Identification of shared loci associated with both Crohn's disease and leprosy in East Asians., PMID:35512355
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis., PMID:35232997
In vitro reconstitution reveals phosphoinositides as cargo-release factors and activators of the ARF6 GAP ADAP1., PMID:33443153
ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus., PMID:33139322
Cancer stem cells and their niche in the progression of squamous cell carcinoma., PMID:32888236
ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival., PMID:31792062
Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes., PMID:31293054
Genome-wide DNA methylation assessment of 'BRCA1-like' early-onset breast cancer: Data from the Australian Breast Cancer Family Registry., PMID:30423315
Refinement of protein-protein complexes in contact map space with metadynamics simulations., PMID:30370948
ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression., PMID:30206251
A mass spectrometry based predictive strategy reveals ADAP1 is phosphorylated at tyrosine 364., PMID:29659066
Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica., PMID:27068087
Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration., PMID:26246585
Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins., PMID:26116512
The Arf GTPase-activating protein family is exploited by Salmonella enterica serovar Typhimurium to invade nonphagocytic host cells., PMID:25670778
Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype., PMID:24940735
Functions of the neuron-specific protein ADAP1 (centaurin-α1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1., PMID:24854535
Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells., PMID:24829397
Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction., PMID:23516302
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-α1 (ADAP1)., PMID:21972134
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells., PMID:21801775
Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1., PMID:21057110
The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent., PMID:19860830
The brain-specific protein, p42(IP4) (ADAP 1) is localized in mitochondria and involved in regulation of mitochondrial Ca2+., PMID:19383085
RanBPM, a novel interaction partner of the brain-specific protein p42IP4/centaurin alpha-1., PMID:18298663
The neuronal Arf GAP centaurin alpha1 modulates dendritic differentiation., PMID:17635995
PI-3-kinase-dependent membrane recruitment of centaurin-alpha2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation., PMID:17284522
Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity., PMID:16805830
p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor., PMID:16341594
Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases., PMID:16287813
Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B., PMID:15923660
Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization., PMID:15778454
The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton., PMID:15679100
Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin., PMID:15106847
Short-term down-regulation of the brain-specific, PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding, adapter protein, p42IP4/centaurin-alpha 1 in rat brain after acoustic and electric stimulation., PMID:15082226
Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization., PMID:14625293
Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate., PMID:14499594
Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C., PMID:12893243
Expression of the brain-specific membrane adapter protein p42IP4/centaurin alpha, a Ins(1,3,4,5)P4/PtdIns(3,4,5)P3 binding protein, in developing rat brain., PMID:12694946
Centaurin-alpha 1 associates in vitro and in vivo with nucleolin., PMID:12565890
Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha., PMID:12499840
Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle., PMID:12018390
Cytohesins and centaurins: mediators of PI 3-kinase regulated Arf signaling., PMID:11295547
For research use only. Not for human or drug use.
