Catalog No.
YHB26601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe78-Pro361
Predicted molecular weight
33.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75610
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Left-right determination factor B, Left-right determination factor 1, LEFTYB, LEFTY1, Protein lefty-1, LEFTB, Protein lefty-B
A Conserved Domain of Cfap298 Governs Left-Right Symmetry Breaking in Vertebrates., PMID:40463022
The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish., PMID:40141403
The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells., PMID:39671433
Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids., PMID:39285481
Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants., PMID:39257761
Identification of critical genes associated with oxidative stress pathways in benzene-induced hematotoxicity., PMID:39170214
Preliminary study on whole genome methylation and transcriptomics in age-related cataracts., PMID:38128790
Exploring the cellular and molecular differences between ovarian clear cell carcinoma and high-grade serous carcinoma using single-cell RNA sequencing and GEO gene expression signatures., PMID:37525249
Thermal inkjet bioprinting drastically alters cell phenotype., PMID:37160133
Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population., PMID:37097539
A Single-Component Optogenetic Gal4-UAS System Allows Stringent Control of Gene Expression in Zebrafish and Drosophila., PMID:36891673
Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs., PMID:36524443
A novel angiogenic effect of PCSK9- regulated genes., PMID:36427678
Construction of Endometrial Carcinoma ceRNA Network and Screening of Key Genes Based on TCGA Database., PMID:35832124
HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs., PMID:35830803
The FGF receptor inhibitor PD173074 modulates Lefty expression in human induced pluripotent stem cells differently depending on the culture conditions., PMID:35306104
Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn's Disease., PMID:34680872
Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways., PMID:33409963
Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma., PMID:33111989
LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis., PMID:32693087
Right, left and cilia: How asymmetry is established., PMID:32571625
Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway., PMID:32065356
Expression of Lefty predicts Merkel cell carcinoma-specific death., PMID:32022949
Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice., PMID:31887266
Proteome analysis of formalin-fixed paraffin-embedded colorectal adenomas reveals the heterogeneous nature of traditional serrated adenomas compared to other colorectal adenomas., PMID:31729028
Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse., PMID:30446628
Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands., PMID:30323168
A mathematical model of the biochemical network underlying left-right asymmetry establishment in mammals., PMID:30292532
Prediction of novel pluripotent proteins involved in reprogramming of male Germline stem cells (GSCs) into multipotent adult Germline stem cells (maGSCs) by network analysis., PMID:30125770
Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells., PMID:30048506
Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency., PMID:29733394
Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway., PMID:29286065
Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish., PMID:29140249
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos., PMID:29138408
Translational co-regulation of a ligand and inhibitor by a conserved RNA element., PMID:29059375
Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma., PMID:28969018
Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells., PMID:28938408
Infertility diagnosis has a significant impact on the transcriptome of developing blastocysts., PMID:28595284
Low Expression of LEFTY1 in Placental Villi Is Associated with Early Unexplained Miscarriage., PMID:30027725
Mechanism for generation of left isomerism in Ccdc40 mutant embryos., PMID:28182636
Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia., PMID:28117656
Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells., PMID:28000155
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells., PMID:27934856
Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning., PMID:27821532
TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling., PMID:27760115
PIERCE1 is critical for specification of left-right asymmetry in mice., PMID:27305836
Determination of testicular function in adolescents with varicocoele - a proteomics approach., PMID:27061999
Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression., PMID:26975355
Lefty1 alleviates renal tubulointerstitial injury in mice with unilateral ureteral obstruction., PMID:26647776
Temporal and spatial requirements for Nodal-induced anterior mesendoderm and mesoderm in anterior neurulation., PMID:26528772
For research use only. Not for human or drug use.
