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Recombinant Human LRP6 Protein, N-His

Catalog #:   YHB25301 Specific References (50) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O75581
Protein length: Ala20-Pro1368
Overview

Catalog No.

YHB25301

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Ala20-Pro1368

Predicted molecular weight

154.41 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O75581

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

LRP6, LRP-6, Low-density lipoprotein receptor-related protein 6

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human LRP6 protein
References

Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET., PMID:40497984

Genetic Aspects of Tooth Agenesis., PMID:40428404

WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling., PMID:40413190

Cancer-associated loss-of-function mutations in KCNQ1 enhance Wnt/β-catenin signalling disrupting epithelial homeostasis., PMID:40410368

Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor., PMID:40399324

MicroRNA-487b-3p Represses Cell Functions and Epithelial-Mesenchymal Transition and Acts as a Prognostic Predictor for Breast Cancer., PMID:40384015

Voglibose Attenuates Amyloid Beta-Induced Memory Deficits in a Rodent Model: A Potential Alzheimer's Therapy via Wnt Signaling Modulation., PMID:40381169

Comprehensive analysis of chronic hepatitis B concurrent with non-alcoholic fatty liver disease: a proteomics report based on clinical liver samples., PMID:40361009

Isolation and characterization of a bioactive compound from Sphingomonas sanguinis DM with cytotoxic and molecular docking analysis., PMID:40341615

Calcaratarin D, a labdane diterpenoid, attenuates bleomycin-induced pulmonary fibrosis by blocking Wnt/β-catenin signaling pathway., PMID:40311955

Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors., PMID:40307870

Identification and Functional Analysis of Novel Mutations in AXIN2 and LRP6 Linked With Non-Syndromic Tooth Agenesis., PMID:40293036

Improvement of spatial memory dysfunction in type 2 diabetic mice through a low-carbohydrate and high-protein diet: Potential role of LRP6/Wnt3a signaling in the hippocampus., PMID:40288500

Canonical Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure., PMID:40280384

miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6., PMID:40192990

The potential of ARL4C and its-mediated genes in atherosclerosis and agent development., PMID:40176913

ABCG8‑mediated sterol efflux increases cancer cell progression via the LRP6/Wnt/β‑catenin signaling pathway in radiotherapy‑resistant MDA‑MB‑231 triple‑negative breast cancer cells., PMID:40116083

Hepcidin knockout exacerbates hindlimb unloading-induced bone loss in mice through inhibiting osteoblastic differentiation., PMID:40102891

Transcriptome analysis of testis and epididymis identifies key genes and pathways regulating gander sperm motility., PMID:40081175

Blocking the Dkk1-LRP6 interaction prevents acute amyloid-β-driven cognitive impairment., PMID:40057150

Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364

Wnt1 oversees microglial activation by the Wnt/LRP5/6 receptor signaling pathway during lipopolysaccharide-mediated toxicity., PMID:40025242

Physical and functional interactions between LDLR family members and CXCR4 in breast cancer., PMID:40022442

Mapk7 enhances osteogenesis and suppresses adipogenesis by activating Lrp6/β-catenin signaling axis in mesenchymal stem cells., PMID:40000807

Functional Evaluation of Neural Tube Defect-Related Missense Mutations Using In Silico Methods., PMID:39950581

The Relationship Between LRP-5 and LRP-6 Gene Mutations and Postmenopausal Type 2 Diabetes and Obesity., PMID:39902284

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity., PMID:39881873

Ablation of LRP6 in alpha-smooth muscle actin-expressing cells abrogates lung inflammation and fibrosis upon bleomycin-induced lung injury., PMID:39873304

A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis., PMID:39870874

Genome-Wide Scans for Selection Signatures in Haimen Goats Reveal Candidate Genes Associated with Growth Traits., PMID:39857271

Evaluation of LRP6, SFRP3, and DVL1 Protein Concentrations in Serum of Patients with Gastroenteropancreatic or Bronchopulmonary Neuroendocrine Tumors., PMID:39796676

Low-density lipoprotein receptor-related protein 6 ameliorates cardiac hypertrophy by regulating CTSD/HSP90α signaling during pressure overload., PMID:39779966

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling., PMID:39745873

Incident Vertebral Fractures During Romosozumab Treatment in a Patient With a Pathogenic LRP5 Variant., PMID:39726666

AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription., PMID:39724412

Diet therapy abates mutant APC and KRas effects by reshaping plasma membrane cholesterol nanodomains., PMID:39709523

Possible Involvement of Hippocampal miR-539-3p/Lrp6/Igf1r Axis for Diminished Working Memory in Mice Fed a Low-Carbohydrate and High-Protein Diet., PMID:39707649

Methylation-modulated PFTK1 regulates gefitinib resistance via Wnt/β-catenin signaling in EGFR mutant non-small-cell lung cancer cells., PMID:39702755

Aberrant Wnt/β-catenin signaling in the mesenchymal stem cells of LZTFL1-depleted mice leads to increased adipogenesis, with implications for obesity., PMID:39662832

A phase I dose-escalation study of LRP5/6 antagonist BI 905677 in patients with advanced solid tumors., PMID:39617530

Gentisic acid prevents the development of atherosclerotic lesions by inhibiting SNX10-mediated stabilization of LRP6., PMID:39603572

Rescue of cochlear vascular pathology prevents sensory hair cell loss in Norrie disease., PMID:39585982

WNT7A-positive dendritic cytonemes control synaptogenesis in cortical neurons., PMID:39576204

The RAAS system SNPs polymorphism is associated with essential hypertension risk in rural areas in northern China., PMID:39512695

Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site., PMID:39502693

DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage., PMID:39478025

MicroRNA-205-5p inhibits the growth and migration of breast cancer through targeting Wnt/β-catenin co-receptor LRP6 and interacting with lncRNAs., PMID:39461917

CDK14 is regulated by IGF2BP2 and involved in osteogenic differentiation via Wnt/β-catenin signaling pathway in vitro., PMID:39447733

EDA Variants Are Responsible for Approximately 90% of Deciduous Tooth Agenesis., PMID:39408781

Osteoclastic ATP6AP2 maintains β-catenin levels to prevent hyper-osteoclastic activation and trabecular bone-loss., PMID:39400061

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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For research use only. Not for human or drug use.

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Recombinant Human LRP6 Protein, N-His [YHB25301]
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