Catalog No.
YHB24001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu1038-Leu1304
Predicted molecular weight
32.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75533
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAP 155, SAP155, SF3B1, Pre-mRNA-splicing factor SF3b 155 kDa subunit, Splicing factor 3B subunit 1, Spliceosome-associated protein 155, SF3b155
Multipurpose RNA maturation factors dysregulate multiple mRNA processing steps simultaneously and provide new therapeutic opportunities., PMID:40485569
Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China., PMID:40474348
[Differences in clinical and laboratory features and survival between Chinese and Western patients with myelodysplastic neoplasm]., PMID:40355351
Significance of Mutation Spots and Concurrent Gene Mutations on Prognosis and Clinical Outcomes in Myelodysplastic Syndromes With SF3B1 Mutation., PMID:40342275
New Approvals in Low- and Intermediate-Risk Myelodysplastic Syndromes., PMID:40334184
Chromatin-bound U2AF2 splicing factor ensures exon inclusion., PMID:40315850
Short Report: The Variants in CHEK2 in Metastatic Uveal Melanoma., PMID:40283643
Co-occurrence of EIF1AX, SF3B1, or BAP1 variants in uveal melanomas: A case series and review., PMID:40271082
Genetic landscape of myelodysplastic syndrome and its prognostic relevance: a study from Pakistan., PMID:40269371
Putrescine modulates alternative splicing of gonadotropin hormone-releasing hormone (GnRH) through differential regulation of splicing factors., PMID:40239543
High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation., PMID:40207633
Imatinib-Induced Clinical Response in ETV6::ACSL6 Myeloid Neoplasm with Eosinophilic Pneumonitis: A Case Report., PMID:40200571
Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations., PMID:40158006
Clinicopathologic Characteristics and Prognostic Profile of Chronic Myeloid Neoplasms With Somatic NF1 Mutations in Adult Patients., PMID:40151938
Identification of pine SF3B1 protein and cross-species comparison highlight its conservation and biological significance in pre-mRNA splicing regulation., PMID:40147324
Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing., PMID:40138349
Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1., PMID:40108537
Identification of diagnostic and prognostic genetic alterations in uveal melanoma using RNA sequencing., PMID:40059100
Sideroblastic anemia in children: challenges in diagnosis and management in three cases., PMID:40042629
SUGP1 loss is the sole driver of SF3B1 hotspot mutant missplicing in cancer., PMID:40027711
RNA-binding proteins as therapeutic targets in cancer., PMID:40016176
Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma., PMID:40011918
DHX9 helicase impacts on splicing decisions by modulating U2 snRNP recruitment in Ewing sarcoma cells., PMID:39950342
Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study., PMID:39948662
Association of Specific Gene Mutations with Immunoglobulin Heavy-Chain Variable Region and Chromosomal Alterations in Chronic Lymphocytic Leukemia Patients in India., PMID:39873992
Acquired mutations in patients with relapsed/refractory CLL who progressed in the ALPINE study., PMID:39853273
Single-cell Rapid Capture Hybridization sequencing reliably detects isoform usage and coding mutations in targeted genes., PMID:39794120
SF3B1: from core splicing factor to oncogenic driver., PMID:39773890
Real-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma., PMID:39739287
Complex Genetic Evolution and Treatment Challenges in Myeloid Neoplasms: A Case of Persistent t(2;3)(p15~23;q26)/MECOM Rearrangement, SF3B1 Mutation, and Transient TNIP1::PDGFRB Chimera., PMID:39730178
SF3B1 thermostability as an assay for splicing inhibitor interactions., PMID:39725033
Structure-Activity Relationship Study of Splicing Modulators on Hsh155/SF3B1 through Chemical Synthesis and Yeast Genetics., PMID:39691513
Iron overload in acquired sideroblastic anemias and MDS: pathophysiology and role of chelation and luspatercept., PMID:39644054
KRAS Variants Are Associated With Survival Outcomes and Genomic Alterations in Biliary Tract Cancers., PMID:39642327
Perianal Paget Disease With an Enteric Phenotype and Associated In-Situ/Dysplastic Glandular Component: Report of a Potentially Novel Entity and Review of the Literature., PMID:39632744
Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing., PMID:39605567
Covalent targeting of splicing in T cells., PMID:39591969
Alternative Splicing: A Potential Therapeutic Target in Hematological Malignancies., PMID:39584923
RNA splicing as a therapeutic target in myelodysplastic syndromes., PMID:39542752
The splicing factor SF3B1 is essential for proper alternative splicing and zygotic genome activation in early porcine embryos., PMID:39521214
BioID proximity mapping reveals novel SAP18 interactions in the prespliceosomal complex., PMID:39522233
Prognostic impact of next-generation sequencing on myelodysplastic syndrome: A single-center experience., PMID:39465815
Clonal hematopoiesis in cardiovascular aging: Insights from the verona heart study., PMID:39460851
Identification of BAY61-3606 Derivatives With Improved Activity in Splicing Modulation That Induces Inclusion of Cassette Exons Similar to the Splicing Factor 3B Subunit 1 Mutation., PMID:39438141
Isoginkgetin and Madrasin are poor splicing inhibitors., PMID:39432454
Hyperactivation of NF-κB signaling in splicing factor mutant myelodysplastic syndromes and therapeutic approaches., PMID:39406588
Therapeutic strategies targeting aberrant RNA splicing in myeloid malignancies., PMID:39406457
Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes., PMID:39388570
The Impact of Spliceosome Inhibition in SF3B1-Mutated Uveal Melanoma., PMID:39374010
[Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches]., PMID:39355878
For research use only. Not for human or drug use.
