Catalog No.
YHB22401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val261-Ala527
Predicted molecular weight
31.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75487
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
K-glypican, GPC4, Glypican-4
Clinical-Genetic Approach to Conditions with Macrocephaly and ASD/Behaviour Abnormalities: Variants in PTEN and PPP2R5D Are the Most Recurrent Gene Mutations in a Patient-Oriented Diagnostic Strategy., PMID:40282429
Evaluation of circulating glypican 4 as a novel biomarker in disease - A comprehensive review., PMID:39961831
The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling., PMID:39956311
Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces., PMID:39684750
Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis., PMID:39570288
GPC4 truncating variant associated with Keipert syndrome and lacrimal punctal agenesis., PMID:38923342
Dichotomous Effects of Glypican-4 on Cancer Progression and Its Crosstalk with Oncogenes., PMID:38612755
Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease., PMID:38424123
Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis., PMID:37986847
Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure., PMID:37844682
Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model., PMID:37664457
Comprehensive in silico analysis of glycosylphosphatidylinositol- anchored protein (GPI-AP) related genes expression profiles in human normal and cancer tissues., PMID:37609818
The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis., PMID:37511353
FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis., PMID:37492748
Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Precancer., PMID:37410084
Intracellular accumulation of tau oligomers in astrocytes and their synaptotoxic action rely on Amyloid Precursor Protein Intracellular Domain-dependent expression of Glypican-4., PMID:37321444
Differentially Expressed Genes Induced by Erythropoietin Receptor Overexpression in Rat Mammary Adenocarcinoma RAMA 37-28 Cells., PMID:37239828
Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue., PMID:37108048
Genome-wide identification of potential odontogenic genes involved in the dental epithelium-mesenchymal interaction during early odontogenesis., PMID:37013486
The effects of a low carbohydrate diet combined with partial meal replacement on obese individuals., PMID:36997952
An investigation of the etiology and follow-up findings in 35 children with overgrowth syndromes, including biallelic SUZ12 variant., PMID:36919607
Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle., PMID:36901723
Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma., PMID:36768928
Circulating Glypican-4 Is a Predictor of 24-Month Overall Survival in Metastatic Breast Cancer., PMID:36750040
Glypican-4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling., PMID:36727620
A novel risk model based on the correlation between the expression of basement membrane genes and immune infiltration to predict the invasiveness of pituitary adenomas., PMID:36686480
Lipid Handling Protein Gene Expression in Colorectal Cancer: CD36 and Targeting miRNAs., PMID:36556492
Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling., PMID:36057966
Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation., PMID:35969759
Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease., PMID:35944770
Evaluation of the association of serum glypican-4 with prevalent and future kidney function., PMID:35715556
Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients., PMID:35202959
Protein source in maturation media affects gene expression in cumulus cells and embryo development in cattle., PMID:34964703
Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status., PMID:34903856
Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice., PMID:34748756
Proteomic Analysis of Exosomes during Cardiogenic Differentiation of Human Pluripotent Stem Cells., PMID:34685602
Glypican 4 mediates Wnt transport between germ layers via signaling filopodia., PMID:34591076
Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly via Low-Density Lipoprotein Receptor-Related Protein 1., PMID:34552470
Heparan Sulfated Glypican-4 Is Released from Astrocytes by Proteolytic Shedding and GPI-Anchor Cleavage Mechanisms., PMID:34301723
Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway., PMID:34210294
Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2., PMID:34131730
Distinct diagnostic and prognostic values of Glypicans gene expression in patients with hepatocellular carcinoma., PMID:33902495
Galanin and glypican-4 levels depending on metabolic and cardiovascular risk factors in patients with polycystic ovary syndrome., PMID:33740336
Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN-4 downregulation., PMID:33528918
Neurocognitive, adaptive, and psychosocial functioning in individuals with Robinow syndrome., PMID:32954672
Characterization of the Robinow syndrome skeletal phenotype, bone micro-architecture, and genotype-phenotype correlations with the osteosclerotic form., PMID:32888393
Serum glypican4 and glycosylphosphatidylinositol-specific phospholipase D levels are associated with adipose tissue insulin resistance in obese subjects with different glucose metabolism status., PMID:32816247
HSPGs glypican-1 and glypican-4 are human neuronal proteins characteristic of different neural phenotypes., PMID:32562306
Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation., PMID:32199612
For research use only. Not for human or drug use.
