Catalog No.
YHB21801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys107-Val296
Predicted molecular weight
23.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75473
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
G-protein coupled receptor 49, G-protein coupled receptor HG38, LGR5, GPR67, GPR49, G-protein coupled receptor 67, Leucine-rich repeat-containing G-protein coupled receptor 5
LiGeR-HN phase III trials of petosemtamab + pembrolizumab and petosemtamab monotherapy in recurrent or metastatic HNSCC., PMID:40511820
RacGAP1 Plays an Oncogenic Role in Lung Adenocarcinoma by Regulating the Wnt/β-Catenin Pathway., PMID:40497948
Automated tissue dissociation for the establishment of human intestinal organoids., PMID:40473694
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling., PMID:40467544
Petosemtamab, a Bispecific Antibody Targeting Epidermal Growth Factor Receptor (EGFR) and Leucine-Rich G Repeat-Containing Protein-Coupled Receptor (LGR5) Designed for Broad Clinical Applications., PMID:40427162
Analysis of immune infiltration in basal cell carcinoma based on transcriptome sequencing and experimental validation of diagnostic biomarkers., PMID:40410644
Insights from the bottom-up development of LGR5-targeting immunotherapeutics., PMID:40405910
CDX1 and CDX2 suppress colon cancer stemness by inhibiting β-catenin-facilitated formation of Pol II-DSIF-PAF1C complex., PMID:40399276
Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems., PMID:40395933
In vitro anti-tumor activities of a novel recombinant immunotoxin targeting differentially overexpressed Leucine-rich repeat-containing G-protein-coupled receptor 5 in cervical cancer., PMID:40376858
Shh agonist enhances maturation in homotypic Lgr5-positive inner ear organoids., PMID:40365278
Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer., PMID:40348815
The cancer stem cells characteristics analysis of LGR5 + cells that influence lung cancer risk by using single cell RNA-seq analysis., PMID:40341189
Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer., PMID:40329330
Stemness in flux: Dissecting intestinal crypt organization with multimodal approaches., PMID:40328226
Phosphatidylinositol 3-Kinase Signaling Enhances Intestinal Crypt Epithelial Cell Recovery after Radiation., PMID:40316215
Comprehensive circRNA expression profile and hub genes screening during human liver development., PMID:40285372
LGR5 interacts with HSP90AB1 to mediate enzalutamide resistance by activating the WNT/β-catenin/AR axis in prostate cancer., PMID:40280884
Associations of blood RNA biomarkers and circulating tumour cells in patients with previously untreated metastatic colorectal cancer., PMID:40259317
ONC201 exerts oncogenic effects beyond its mitochondria-disturbing role in neuroblastoma subsets., PMID:40210723
Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer., PMID:40180576
Abortive PDCoV infection triggers Wnt/β-catenin pathway activation, enhancing intestinal stem cell self-renewal and promoting chicken resistance., PMID:40135895
Obese Adipose Tissue Extracellular Vesicles Activate Mitochondrial Fatty Acid β-oxidation to Drive Colonic Stemness., PMID:40122519
To explore the potential combined treatment strategy for colorectal cancer: Inhibition of cancer stem cells and enhancement of intestinal immune microenvironment., PMID:40120791
Modulation of intestinal signal transduction pathways: Implications on gut health and disease., PMID:40118324
FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development., PMID:40102860
Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea., PMID:40091489
Molecular gene signature of circulating stromal/stem cells., PMID:40069498
Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury., PMID:40052554
Endothelial OX40 activation facilitates tumor cell escape from T cell surveillance through S1P/YAP-mediated angiogenesis., PMID:40026246
A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration., PMID:40013494
Diet links gut chemistry with cancer risk in C57Bl/6 mice and human colorectal cancer patients., PMID:39975138
Inhibition of LGR5/β-Catenin Axis and Activation of miR134 Are Critically Involved in Apoptotic Effect of Sanggenol L in Hepatocellular Carcinoma., PMID:39956588
FSP1/S100A4-Expressing Stem/Progenitor Cells Are Essential for Temporomandibular Joint Growth and Homeostasis., PMID:39953712
The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells., PMID:39952238
Modulation of β-Catenin promotes WNT expression in macrophages and mitigates intestinal injury., PMID:39934819
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer., PMID:39930084
Casein Glycomacropeptide Regulates Gene Expression in Intestinal Epithelial Cells: Effect of Simulated Gastrointestinal Digestion and Peptide Microencapsulation., PMID:39921639
Inhibition of stemness and PD-L1 expression by Pien Tze Huang enhances T cell-mediated killing of colorectal cancer., PMID:39914691
Effect of short-term gravitational changes on the human minor salivary gland stem cell characteristics., PMID:39914647
Dual independent mechanisms underlying gut epithelial remodeling upon sugar substitute consumption., PMID:39902882
Preparation and characterization of LGR5 LOOP region-specific nanobodies., PMID:39892531
Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer., PMID:39884575
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT., PMID:39874220
Role of Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors 4-6 (LGR4-6) in the Ovary and Other Female Reproductive Organs: A Literature Review., PMID:39874091
Intestinal stem cells in intestinal homeostasis and colorectal tumorigenesis., PMID:39872442
Dietary fermented mixed ingredient product enhances growth performance and intestinal stem cell-mediated epithelial regeneration through Wnt/β-catenin pathway in layer chicks., PMID:39854967
A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges During Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer., PMID:39841093
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance., PMID:39821694
Protective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells., PMID:39808671
For research use only. Not for human or drug use.
