Catalog No.
YHB21701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser130-Ile431
Predicted molecular weight
36.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75469
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NR1I2, SXR, PXR, Steroid and xenobiotic receptor, Orphan nuclear receptor PXR, Nuclear receptor subfamily 1 group I member 2, Pregnane X receptor, Orphan nuclear receptor PAR1
Sea buckthorn regulates PXR/CAR/NF-κB signaling and restores CYP2C metabolic function in BCG-induced hepatitis., PMID:40513919
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA., PMID:40466953
The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells., PMID:40395611
Blockade of the estrogen receptor alpha-pregnane X receptor axis protects ovariectomized mice against ethanol-induced hepatotoxicity., PMID:40381698
The intestinal functions of PXR and CAR., PMID:40378938
Pregnane X receptor attenuates gold nanoparticles' toxicity through accelerating zebrafish embryo hatching., PMID:40339275
Bile acid regulation of xenobiotic nuclear receptors on the expressions of orosomucoids in the liver., PMID:40327538
[The Association of Polymorphisms Drug Metabolism and Transport of Imatinib Related Gene with Severe Hematology Adverse Effects in Chronic Myeloid Leukemia Patients]., PMID:40326103
St. John's Wort Extract Increases Pgp Expression in the Brain but Not in the Small Intestine or the Liver of Wistar Rats., PMID:40325522
Cholestasis in hepatitis E virus infection., PMID:40308815
Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions., PMID:40301309
Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35., PMID:40274281
Tanshinone IIA Improves Intestinal Barrier Integrity in Septic Rats., PMID:40267092
Comparison of the impact of chlordecone and its metabolite chlordecol on genes involved in pesticide metabolism in HepG2 cell line., PMID:40252817
Pregnane X receptor alleviates sepsis-induced liver injury through activation of yes-associated protein in mice., PMID:40234620
Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids., PMID:40233301
Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response., PMID:40205519
Switch/sucrose non-fermentable complex interacts with constitutive androstane receptor to regulate drug-metabolizing enzymes and transporters in the liver., PMID:40158296
L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling., PMID:40158232
Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor., PMID:40076408
Efficient protein quantification in drug metabolism and pharmacokinetics with an accelerated proteomic workflow., PMID:40068543
Association of NR1I2 Polymorphism with Midazolam Clearance in Mechanically Ventilated ICU Patients: A Population Pharmacokinetic and Pharmacogenetic Study., PMID:40066084
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate., PMID:40036302
Use of an extensively humanized mouse model to predict the risk of drug-drug interactions in patients receiving dexamethasone., PMID:40023599
Impact of sex and pregnancy on hepatic CYP3A4 expression and activity in a humanized mouse model., PMID:40023573
Insights of direct and indirect regulation of PXR through phosphorylation in fatty liver disease., PMID:40023513
LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver., PMID:40023092
Therapeutic effects of amisulpride in male schizophrenics: Role of short-chain fatty acids and gene expression changes., PMID:40020893
Proteomics Profiling Reveals Pharmaceutical Excipient PEG400 Induces Nuclear-Receptor-Activation-Affected Lipid Metabolism and Metabolic Enzyme Expression., PMID:40004195
Hibiscus sabdariffa calyx extract protects human keratinocyte cells from fluoranthene-induced ferroptosis via the repression of aryl hydrocarbon receptor., PMID:39947066
A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target., PMID:39923198
The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model., PMID:39915454
Marked differences in thyroxine (T4) metabolism following in vitro exposure of Wistar rat and human hepatocytes to several reference CAR/PXR nuclear receptor activators., PMID:39909212
An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice., PMID:39900639
Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant., PMID:39886943
AFB1 consolidates HBV harm to induce liver injury and carcinogenic risk by inactivating FTCD-AS1-PXR-MASP1 axis., PMID:39824452
miR-18a-5p/PXR/SREBP2 Was Involved in MAFLD Associated With Methyl Tert-Butyl Ether Among Petrol Station Workers., PMID:39821525
Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor., PMID:39809031
Modulation of inflammatory signaling by vitamin E metabolites and its therapeutic implications., PMID:39764767
How Uremic Toxins Alter Atorvastatin Disposition: Molecular Mechanisms of Inhibition of the Enzyme CYP3A4., PMID:39757457
The impact of CYP3A5, NR1I2, and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical outcomes in adult allogeneic haematopoietic stem cell transplantation., PMID:39754510
The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity., PMID:39718591
Atractylodes macrocephala Koidz polysaccharide ameliorates DSS-induced colitis in mice by regulating the gut microbiota and tryptophan metabolism., PMID:39667762
Activation of pregnane X receptor sensitizes alcoholic steatohepatitis by transactivating fatty acid binding protein 4., PMID:39664417
Cassia mimosoides L. decoction improves non-alcoholic fatty liver disease by modulating the pregnane X receptor., PMID:39631715
Interaction of Phyllanthus amarus extract and its lignans with human xenobiotic receptors, drug metabolizing enzymes and drug transporters., PMID:39571700
Bioinformatics combined with network pharmacology and experimental validation to identify key biomarkers of hepatocellular carcinoma and corresponding compounds in Radix Astragali and Pueraria Mirifica., PMID:39549064
Role of Bile Acid Receptors in the Development and Function of Diabetic Nephropathy., PMID:39534198
Pre-ADMET studies of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, the bioactive intestinal metabolite of proanthocyanidins., PMID:39526505
Pregnane X receptor activation promotes hematopoiesis during liver regeneration by inducing proliferation of hematopoietic stem and progenitor cells in mice., PMID:39522624
For research use only. Not for human or drug use.
