Catalog No.
YHB21301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe571-Leu977
Predicted molecular weight
49.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75460
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, ERN1, Ire1-alpha, hIRE1p, Serine/threonine-protein kinase/endoribonuclease IRE1, Inositol-requiring protein 1, IRE1
FPPS Downregulation Attenuates Endoplasmic Reticulum Stress in Pulmonary Epithelial Cells., PMID:40484977
The effects of inhibiting IRE1α on the viability of ovarian granulosa cells., PMID:40461537
[Mechanism of Xiangsha Liujunzi Decoction in improving autophagy in interstitial cells of Cajal of rats with functional dyspepsia by regulation of IRE1/ASK1/JNK pathway]., PMID:40461233
Dual Inhibition of IRE1α and YAP Signaling as a Potential Therapy for Epithelial Ovarian Carcinoma., PMID:40460387
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity., PMID:40437698
Dual roles of IRE1α inhibition in reversing mitochondrial ROS-induced CD8+ T-cell senescence and exerting direct antitumor effects in multiple myeloma., PMID:40425229
Cadmium induces autophagy via IRE1 signaling pathway activated by Ca2 + in GC-2spd cells., PMID:40398541
Neutrophil extracellular traps induce fibroblast ferroptosis via IRE1α/XBP1-mediated ER stress to impair diabetic wound healing., PMID:40379156
Nephroprotective effects of hesperidin on ifosfamide-induced acute nephrotoxicity in rats: Role of NF-κB/TNF-α/ IL-1β, p53/caspase-3/Bax/Bcl-2, and ATF6/IRE1/PERK/GRP78 signaling pathways., PMID:40373990
Effect of quercetin on the IRE1-XBP1 apoptotic pathway in Cadmium-treated rat testes., PMID:40350680
IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity., PMID:40349346
ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways., PMID:40347515
Inositol-Requiring Enzyme 1 pathway and autophagy drive sequential response of endothelial cells to febrile range hyperthermia., PMID:40333654
G protein-coupled estrogen receptor reduces the breast cancer cell survival by regulating the IRE1α/miR-17-5p/TXNIP pathway., PMID:40328365
Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses., PMID:40315054
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition., PMID:40304759
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice., PMID:40244655
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure., PMID:40231944
Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells., PMID:40215234
ALKBH5 Inhibits YTHDF2-m6A-Mediated Degradation of RCN1 mRNA to Promote Keloid Formation by Activating IRE1α-XBP1-Mediated ER Stress., PMID:40214031
A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth., PMID:40208872
Role of AMPKα2 in regulating the IRE1α-JNK pathway in metabolic dysfunction-associated fatty liver disease., PMID:40195661
PRKCSH enhances colorectal cancer radioresistance via IRE1α/XBP1s-mediated DNA repair., PMID:40189587
Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway., PMID:40170728
Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway., PMID:40169922
Inhibition of enzymatic activity of HRD1 results in death of cells derived from glioblastoma multiforme, neuroblastoma, and normal astrocytes., PMID:40162509
Ferroptosis contributed to endoplasmic reticulum stress in preterm birth by targeting LHX1 and IRE-1., PMID:40157471
Mettl3 deficiency leads to impaired insulin secretion via regulating Ire1a of mature β-cells in mice., PMID:40155600
Modulation of Ire1-Xbp1 Defense Pathway in Encephalomyocarditis Virus-Infected HeLa Cells., PMID:40143290
Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice., PMID:40120978
Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay., PMID:40112799
IRE1α-mediated UPR activation in gastrointestinal cancers: Adaptive mechanisms and therapeutic potential., PMID:40097091
IRE1α/TRAF2/NF-κB pathway promotes apoptosis via regulating inflammatory cytokines and aggravates brain injury after SAH., PMID:40089218
Diff erent expression of genes involved in unfolded protein response in multiple myeloma and extramedullary dis ease patients., PMID:40088436
The impact of ERN1 endoribonuclease activity inhibition on TOB1, HBEGF, and TWIST1 genes expression in U87MG glioblastoma cells., PMID:40073406
The ERN1 signaling pathway of unfolded protein controls the expression of EDEM1 and its hypoxic regulation in glioblastoma cells., PMID:40073403
Folic acid intervention ameliorates hepatic steatosis after long-term alcohol exposure by alleviating endoplasmic reticulum stress., PMID:40054675
Molecular docking- and reporter-based screening identify dicoumarol against ER stress-induced liver injury in mice through inhibiting IRE1α activity., PMID:40049366
Asperuloside promotes innate immunity via IRE-1/XBP-1 mediated unfolded protein response., PMID:40024200
Dynamic Modulation of IRE1α-XBP1 Signaling by Adenovirus., PMID:40005508
The protective role of the IRE1α/XBP1 signaling cascade in autophagy during ischemic stress and acute kidney injury., PMID:39983812
PARP-16 regulates the PERK and IRE-1α Mediated Unfolded Protein Response in Japanese Encephalitis Virus-Infected Neural Stem/Progenitor Cells., PMID:39979689
Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B., PMID:39979221
Gefitinib induces apoptosis in Caco-2 cells via ER stress-mediated mitochondrial pathways and the IRE1α/JNK/p38 MAPK signaling axis., PMID:39924616
Artemisinin alleviates astrocyte overactivation and neuroinflammation by modulating the IRE1/NF-κB signaling pathway in in vitro and in vivo Alzheimer's disease models., PMID:39826816
IRE1 is a promising therapeutic target in pancreatic cancer., PMID:39819023
Unfolded protein response modulates Tyrosinase levels and melanin production during melanogenesis., PMID:39818444
Mechanism of dexmedetomidine in brain injury of infant rats via the IRE1α/NF-κB/CHOP pathway., PMID:39815639
Unfolded protein response during the progression of colorectal carcinogenesis., PMID:39813534
Small protein ERSP encoded by LINC02870 promotes triple negative breast cancer progression via IRE1α/XBP1s activation., PMID:39799200
For research use only. Not for human or drug use.
