Catalog No.
YHB17201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile109-Leu369
Predicted molecular weight
54.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75367
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone macroH2A1, mH2A1, H2A/y, MACROH2A1, Medulloblastoma antigen MU-MB-50.205, Core histone macro-H2A.1, H2AFY, Histone H2A.y
Regulation of Genome Architecture in Huntington's Disease., PMID:40287840
Comprehensive Proteomics and Machine Learning Analysis to Distinguish Follicular Adenoma and Follicular Thyroid Carcinoma from Indeterminate Thyroid Nodules., PMID:40205804
Nuclear PD-L1 compartmentalization suppresses tumorigenesis and overcomes immunocheckpoint therapy resistance in mice via histone macroH2A1., PMID:39545415
Extracellular Histones Profiles of Pediatric H3K27-Altered Diffuse Midline Glioma., PMID:39514166
Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability., PMID:39484415
Epigenetic regulation of cell state by H2AFY governs immunogenicity in high-risk neuroblastoma., PMID:39255035
Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1., PMID:39218869
Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome., PMID:39189450
A FACT about macroH2A removal in immune gene activation., PMID:39178834
FACT mediates the depletion of macroH2A1.2 to expedite gene transcription., PMID:39116874
macroH2A1 drives nucleosome dephasing and genome instability in histone humanized yeast., PMID:38990716
Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice., PMID:37926763
MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes., PMID:37852977
Integrative CUT&Tag-RNA-Seq analysis of histone variant macroH2A1-dependent orchestration of human induced pluripotent stem cell reprogramming., PMID:37846557
Genome-wide identification of mammalian cell-cycle invariant and mitotic-specific macroH2A1 domains., PMID:37778979
Recruitment of the Histone Variant MacroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation., PMID:37681907
HSV-1 exploits host heterochromatin for nuclear egress., PMID:37516914
Designing a Light-Induced Glycosylation Reaction for Poststage Synthesis of ADP-2″-Deoxyribosyl Derivatives., PMID:37222442
Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19., PMID:36451245
Profiling of cell-free DNA methylation and histone signatures in pediatric NAFLD: A pilot study., PMID:36264206
Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex., PMID:35833506
MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines., PMID:35732123
Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice., PMID:35590030
Joining the PARty: PARP Regulation of KDM5A during DNA Repair (and Transcription?)., PMID:35532219
Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs., PMID:35511867
Evolution, structure and function of divergent macroH2A1 splice isoforms., PMID:35422391
The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes., PMID:35362516
Evolution of a histone variant involved in compartmental regulation of NAD metabolism., PMID:34887560
MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR., PMID:34887557
Spatial and Functional Organization of Human Papillomavirus Replication Foci in the Productive Stage of Infection., PMID:34749533
Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice., PMID:34469727
The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma., PMID:34440260
Phosphorylation within Intrinsic Disordered Region Discriminates Histone Variant macroH2A1 Splicing Isoforms-macroH2A1.1 and macroH2A1.2., PMID:34356514
Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice., PMID:34320234
LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2., PMID:34223906
MacroH2A1.2 deficiency leads to neural stem cell differentiation defects and autism-like behaviors., PMID:34046991
Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions., PMID:34003252
The diagnostic and prognostic value of H2AFY in hepatocellular carcinoma., PMID:33858382
In silico approach to understand the epigenetic mechanism of SARS-CoV-2 and its impact on the environment., PMID:33842674
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells., PMID:33590792
Integrated spatial genomics reveals global architecture of single nuclei., PMID:33505024
Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer's disease-associated markers in 3xTg-AD mice., PMID:33472690
Dysregulated healing responses in diabetic wounds occur in the early stages postinjury., PMID:33350981
A Lipidomic Signature Complements Stemness Features Acquisition in Liver Cancer Cells., PMID:33182805
LSH mediates gene repression through macroH2A deposition., PMID:33159050
Upregulated mH2A1 serves as an unfavorable prognostic indicator and promotes the progress of hepatocellular carcinoma (HCC)., PMID:33058912
Circulating histone signature of human lean metabolic-associated fatty liver disease (MAFLD)., PMID:32819448
Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs., PMID:32738290
Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability., PMID:32649884
Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence., PMID:32645394
For research use only. Not for human or drug use.
