Catalog No.
YHB15501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu479-Ile701
Predicted molecular weight
28.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75342
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALOX12B, Epidermis-type lipoxygenase 12, Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase
Comprehensive analysis of metabolism-related gene biomarkers reveals their impact on the diagnosis and prognosis of triple-negative breast cancer., PMID:40217479
Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes., PMID:40046180
Identification of ALOX12B Gene Expression, Evolution, and Potential Functional Sites in Horn Development of Sheep., PMID:39795938
Structural and Functional Biology of Mammalian ALOX Isoforms with Particular Emphasis on Enzyme Dimerization and Their Allosteric Properties., PMID:39596127
Molecular analysis of inherited disorders of cornification in polish patients show novel variants and functional data and provokes questions on the significance of secondary findings., PMID:39501396
Eicosanoid biosynthesizing enzymes in Prototheria., PMID:39389415
Varying the ratio of Lys: Met through enhancing methionine supplementation improved milk secretion ability through regulating the mRNA expression in bovine mammary epithelial cells under heat stress., PMID:38983772
A novel fatty acid metabolism-related signature identifies MUC4 as a novel therapy target for esophageal squamous cell carcinoma., PMID:38816411
Cross-Sectional Study on Autosomal Recessive Congenital Ichthyoses: Association of Genotype with Disease Severity, Phenotypic, and Ultrastructural Features in 74 Italian Patients., PMID:38588653
Autosomal recessive ALOX12B gene and consecutive collodion baby., PMID:38514164
Solanine induces ferroptosis in colorectal cancer cells through ALOX12B/ADCY4 molecular axis., PMID:38244223
Whole exome sequencing identifies novel pathogenic variants in TGM1 and ALOX12B in patients with hereditary ichthyosis., PMID:38060040
Factors predicting the occurrence of disease-causing variants on next-generation sequencing in children with steroid-resistant nephrotic syndrome - implications for resource-constrained settings., PMID:37335381
RNA-Sequencing Combined With Genome-Wide Allele-Specific Expression Patterning Identifies ZNF44 Variants as a Potential New Driver Gene for Pediatric Neuroblastoma., PMID:37161925
A case of self-improving collodion ichthyosis associated with a rare variant of the ALOX12B gene., PMID:37040911
Mutational Spectrum of the ABCA12 Gene and Genotype-Phenotype Correlation in a Cohort of 64 Patients with Autosomal Recessive Congenital Ichthyosis., PMID:36980989
Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype., PMID:36972303
Longitudinal Plasma Proteomics-Derived Biomarkers Predict Response to MET Inhibitors for MET-Dysregulated NSCLC., PMID:36612298
Novel homozygous missense mutation c.1654G>T in the ALOX12B gene causing congenital ichthyosiform erythroderma., PMID:36258281
ALOX12B and PNPLA1 Have Distinct Roles in Epidermal Lipid Lamellar Organization., PMID:36116510
Growth State-Dependent Expression of Arachidonate Lipoxygenases in the Human Endothelial Cell Line EA.hy926., PMID:36010555
Identification of the first congenital ichthyosis case caused by a homozygous deletion in the ALOX12B gene due to chromosome 17 mixed uniparental disomy., PMID:36003334
Survival-related indicators ALOX12B and SPRR1A are associated with DNA damage repair and tumor microenvironment status in HPV 16-negative head and neck squamous cell carcinoma patients., PMID:35768785
Genotype of autosomal recessive congenital ichthyosis from a tertiary care center in India., PMID:35412663
[Clinical and genetic analysis of a patient with autosomal recessive congenital ichthyosis due to compound heterozygous variants of ALOX12B gene]., PMID:35315045
Osteogenesis Imperfecta: Search for Mutations in Patients from the Republic of Bashkortostan (Russia)., PMID:35052464
Quality of life and clinical characteristics of self-improving congenital ichthyosis within the disease spectrum of autosomal-recessive congenital ichthyosis., PMID:34908195
Pseudodominant inheritance of self-improving collodion ichthyosis with homozygous mutation in the ALOX12B gene., PMID:34379964
High rate of self-improving phenotypes in children with non-syndromic congenital ichthyosis: case series from south-western Germany., PMID:34273205
The impact of CPT1B rs470117, LEPR rs1137101 and BDNF rs6265 polymorphisms on the risk of developing obesity in an Italian population., PMID:34176754
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α., PMID:33749892
Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support a Specific Role in Lipid-Protein Cross-Linking., PMID:33607042
Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients., PMID:33435499
Genetic variants as biomarkers for progression and resistance in multiple myeloma., PMID:33338886
Expression profile of lipoxygenases in gingival tissues of human periodontitis., PMID:32677134
Eicosanoid biosynthesis in marine mammals., PMID:32627384
Mutation in ALOX12B likely cause of POI and also ichthyosis in a large Iranian pedigree., PMID:32253496
Analysis of the Expression of Regulator Genes in Kupffer Cells and Monocytes., PMID:32157510
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat., PMID:31353262
[27-Year-Old Patient with Scaly Skin]., PMID:31350750
Conditional Alox12b Knockout: Degradation of the Corneocyte Lipid Envelope in a Mouse Model of Autosomal Recessive Congenital Ichthyoses., PMID:31276677
Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis., PMID:31168818
Measurement of trihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible biomarker of barrier function in atopic dermatitis., PMID:30608955
Transcriptomic and lipidomic profiling of eicosanoid/docosanoid signalling in affected and non-affected skin of human atopic dermatitis patients., PMID:30575130
CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis., PMID:30300788
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers., PMID:30258081
Mutation update for CYP4F22 variants associated with autosomal recessive congenital ichthyosis., PMID:30011118
Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates., PMID:28236338
Diminished protein-bound ω-hydroxylated ceramides in the skin of patients with ichthyosis with 12R-lipoxygenase (LOX) or eLOX-3 deficiency., PMID:28235238
For research use only. Not for human or drug use.
