Catalog No.
YHB12401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr106
Predicted molecular weight
38.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75185
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATPase 2C2, Secretory pathway Ca(2+)-ATPase 2, ATP2C2, KIAA0703, Calcium-transporting ATPase type 2C member 2, SPCA2
Differential functional role of Orai1 variants in constitutive Ca2+ entry and calcification in luminal breast cancer cells., PMID:39303919
Exome-wide evidence of compound heterozygous effects across common phenotypes in the UK Biobank., PMID:38944039
A novel imprinted locus on bovine chromosome 18 homologous with human chromosome 16q24.1., PMID:38546894
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging., PMID:38173016
ATP2C2 as a novel immune-related marker that defines the tumor microenvironment in triple-negative breast cancer., PMID:37588742
Identification of an endoplasmic reticulum stress-related gene signature to predict prognosis and potential drugs of uterine corpus endometrial cancer., PMID:36899615
Comparative transcriptome analysis in the caput segment of yak and cattleyak epididymis., PMID:36368116
Integrative Analyses Identify Potential Key Genes and Calcium-Signaling Pathway in Familial Atrioventricular Nodal Reentrant Tachycardia Using Whole-Exome Sequencing., PMID:35924220
A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts., PMID:35769418
Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry., PMID:35063802
Study of rare genetic variants in TM4SF20, NFXL1, CNTNAP2, and ATP2C2 in Pakistani probands and families with language impairment., PMID:34540591
ATP2C2 Has Potential to Define Tumor Microenvironment in Breast Cancer., PMID:33936088
A rare missense variant in the ATP2C2 gene is associated with language impairment and related measures., PMID:33864365
Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma., PMID:36046118
The pancreas-specific form of secretory pathway calcium ATPase 2 regulates multiple pathways involved in calcium homeostasis., PMID:31676354
A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells., PMID:31076498
An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1., PMID:30923126
Store-independent Orai1-mediated Ca2+ entry and cancer., PMID:30921687
Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership., PMID:30718673
RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization., PMID:30443032
Genome-wide association meta-analysis of age at first cannabis use., PMID:30003630
ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR., PMID:29201552
Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation., PMID:29191953
Secretory pathway Ca2+ -ATPases promote in vitro microcalcifications in breast cancer cells., PMID:28618103
[Environmental and genetic variables related with alterations in language acquisition in early childhood]., PMID:28000910
SPCA2 couples Ca2+ influx via Orai1 to Ca2+ uptake into the Golgi/secretory pathway., PMID:27692665
The Ca2+/Mn2+-transporting SPCA2 pump is regulated by oxygen and cell density in colon cancer cells., PMID:27316461
Identification of novel inhibitors of human SPCA2., PMID:27297103
Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells., PMID:27017909
Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders., PMID:25448322
Deletion of 16q24.1 supports a role for the ATP2C2 gene in specific language impairment., PMID:25296922
Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype., PMID:24940735
[Case no. 4. Bullous dermatosis]., PMID:23790660
New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer., PMID:23670239
Decoding the genetics of speech and language., PMID:23228431
Calcium around the Golgi apparatus: implications for intracellular membrane trafficking., PMID:22453953
Structural evolution and tissue-specific expression of tetrapod-specific second isoform of secretory pathway Ca2+-ATPase., PMID:22240025
Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction., PMID:21674634
DCDC2, KIAA0319 and CMIP are associated with reading-related traits., PMID:21457949
Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects., PMID:21165691
Genetic advances in the study of speech and language disorders., PMID:20955937
Store-independent activation of Orai1 by SPCA2 in mammary tumors., PMID:20887894
MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2., PMID:20599950
Recent advances in the genetics of language impairment., PMID:20193051
CMIP and ATP2C2 modulate phonological short-term memory in language impairment., PMID:19646677
Hepatic cirrhosis, dystonia, polycythaemia and hypermanganesaemia--a new metabolic disorder., PMID:18392750
Localization of plasma membrane and secretory calcium pumps in the mammary gland., PMID:18334228
Regulation of Ca2+ mobilization by prolactin in mammary gland cells: possible role of secretory pathway Ca2+-ATPase type 2., PMID:17129574
Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses., PMID:16332677
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions., PMID:15831496
For research use only. Not for human or drug use.
