Catalog No.
YHB01601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp265
Predicted molecular weight
32.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60828
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPW38, PQBP1, Polyglutamine tract-binding protein 1, PQBP-1, Npw38, 38 kDa nuclear protein containing a WW domain, Polyglutamine-binding protein 1
[Clinical analysis of a child with heterotopic ventricular gray matter Renpenning syndrome caused by PQBP1 gene mutation and a literature review]., PMID:40372223
Renpenning syndrome related to a missense variant in polyglutamine-binding protein 1 (PQBP1): Two pediatric cases from a Chinese family and literature review., PMID:39932334
Role of PQBP1 in Pathogen Recognition-Impact on Innate Immunity., PMID:39205314
PQBP3/NOL7 is an intrinsically disordered protein., PMID:39126896
Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis., PMID:39037895
Polyglutamine binding protein 1 regulates neurite outgrowth through recruiting N-WASP., PMID:38971314
Splicing Factor PQBP1 Curtails BAX Expression to Promote Ovarian Cancer Progression., PMID:38342602
Phase separation as a possible mechanism for dosage sensitivity., PMID:38225666
Molecular Determinants of PQBP1 Binding to the HIV-1 Capsid Lattice., PMID:38128824
Molecular consequences of PQBP1 deficiency, involved in the X-linked Renpenning syndrome., PMID:38030819
Splicing Modulators Are Involved in Human Polyglutamine Diversification via Protein Complexes Shuttling between Nucleus and Cytoplasm., PMID:37298574
PQBP1 regulates the cellular inflammation induced by avian reovirus and interacts with the viral p17 protein., PMID:37201645
PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation., PMID:36943865
The role of PQBP1 in neural development and function., PMID:36815699
Identification of a DNA methylation signature for Renpenning syndrome (RENS1), a spliceopathy., PMID:36797465
Two-step recognition of HIV-1 DNA in the cytosol., PMID:36153261
[Clinical and genetic analysis of a child with disorder of sex development]., PMID:35929938
Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA., PMID:35809572
PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity., PMID:35682906
Identification and Functional Analyses of Host Proteins Interacting with the p17 Protein of Avian Reovirus., PMID:35632635
Putative Concussion Biomarkers Identified in Adolescent Male Athletes Using Targeted Plasma Proteomics., PMID:34987469
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation., PMID:34782623
Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients., PMID:34493366
A mild clinical and neuropsychological phenotype of Renpenning syndrome: A new case report with a maternally inherited PQBP1 missense mutation., PMID:34470565
The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway., PMID:34385679
Protocol for interfering peptide injection into adult mouse hippocampus and spatial memory testing., PMID:34337444
PQBP1: A New Player in Metabotropic Glutamate Receptor Signaling and Synaptic Plasticity., PMID:34091808
Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'., PMID:33734395
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis., PMID:33675743
Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability., PMID:33668121
PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation., PMID:33662272
Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression., PMID:33577922
Generation of an urine-derived induced pluripotent stem cell line WMUi017-A from a X-linked Renpenning syndrome (X-RSY) patient with the hemizygous PQBP1 gene mutation p.P609A (c.1825C>G)., PMID:33477035
A genome-wide methylation study reveals X chromosome and childhood trauma methylation alterations associated with borderline personality disorder., PMID:33414392
Renpenning Syndrome in a Turkish Patient: de novo Variant c.607C>T in PACS1 and Hypogammaglobulinemia Phenotype., PMID:32903913
Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients., PMID:32550556
The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin β2 receptor., PMID:32041777
PQBP1, an intellectual disability causative gene, affects bone development and growth., PMID:31959475
A Proteomic Connectivity Map for Characterizing the Tumor Adaptive Response to Small Molecule Chemical Perturbagens., PMID:31846293
Renpenning syndrome in a female., PMID:31840929
Renpenning syndrome in an Indian patient., PMID:31840915
Microphthalmos-anophthalmos-coloboma (MAC) spectrum in two brothers with Renpenning syndrome due to a truncating mutation in the polyglutamine tract binding protein 1 (PQBP1) gene., PMID:31718390
Induced pluripotent stem cells (iPSCs) derived from a renpenning syndrome patient with c.459_462delAGAG mutation in PQBP1 (PEIi001-A)., PMID:31698189
High Expression of PQBP1 and Low Expression of PCK2 are Associated with Metastasis and Recurrence of Osteosarcoma and Unfavorable Survival Outcomes of the Patients., PMID:31205570
Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy., PMID:31059280
Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers., PMID:30951824
Identification of candidate gene FAM183A and novel pathogenic variants in known genes: High genetic heterogeneity for autosomal recessive intellectual disability., PMID:30500859
Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability., PMID:30372687
The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology., PMID:30283027
Phenotypic and molecular insights into PQBP1-related intellectual disability., PMID:30244542
For research use only. Not for human or drug use.
