Catalog No.
YHA95701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp389-Pro583
Predicted molecular weight
24.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60610
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein diaphanous homolog 1, DIAP1, DRF1, Diaphanous-related formin-1, DIAPH1
[Moyamoya Disease and the RNF213 Gene]., PMID:40438010
Schizophrenia-Related Synaptic Dysfunction and Abnormal Sensorimotor Gating in Akap11-Deficient Mice., PMID:40408419
Negative cooperativity regulates ligand activation of DIAPH1 and other diaphanous related formins., PMID:40399622
Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin., PMID:40368919
Mechanistic underpinnings of AGEs-RAGE via DIAPH1 in ischemic, diabetic, and failing hearts., PMID:40132210
AGER-dependent macropinocytosis drives resistance to KRAS-G12D-targeted therapy in advanced pancreatic cancer., PMID:39879317
Host factor DIAPH1 regulates pseudorabivirus replication by modulating the dynamics of cytoskeleton., PMID:39842589
Hearing loss occurs prior to thrombocytopenia in both mice and humans with DFNA1., PMID:39831886
Genetic analysis of patients with low-frequency non-syndromic hearing loss., PMID:39720982
A Novel Homozygote Pathogenic Variant in the DIAPH1 Gene Associated With Seizures, Cortical Blindness, and Microcephaly Syndrome (SCBMS): Report of a Family and Literature Review., PMID:39578953
Lovastatin-mediated pharmacological inhibition of Formin protein DIAPH1 suppresses tumor immune escape and boosts immunotherapy response., PMID:39571269
A novel frameshift mutation in the DIAPH1 gene causes a Chinese family autosomal dominant nonsyndromic hearing loss: Mutation in DIAPH1 causes hearing loss., PMID:39542281
Assessment of cardiac and skeletal muscle metabolites using 1H-MRS and chemical-shift encoded magnetic resonance imaging: Impact of diabetes, RAGE, and DIAPH1., PMID:39468867
FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms., PMID:39430739
Targeting RAGE-signaling pathways in the repair of rotator-cuff injury., PMID:39395136
RAGE/DIAPH1 and atherosclerosis through an evolving lens: Viewing the cell from the "Inside - Out"., PMID:39131441
DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans., PMID:39120629
DIAPH1 mutations predict a favorable outcome for de novo MDS., PMID:39084456
Immune dysregulation due to bi-allelic mutation of the actin remodeling protein DIAPH1., PMID:39076976
Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer., PMID:39072170
Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration., PMID:39021083
Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development., PMID:39010074
RAGE/DIAPH1 Axis and Cardiometabolic Disease: From Nascent Discoveries to Therapeutic Potential., PMID:38924438
A Novel Variant in the DIAPH1 Gene Causing Macrothrombocytopenia and Non-syndromic Hearing Loss in a Pediatric Saudi Girl., PMID:38915998
The DIAPH3 linker specifies a β-actin network that maintains RhoA and Myosin-II at the cytokinetic furrow., PMID:38897998
Mechanisms of actin filament severing and elongation by formins., PMID:38843827
Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein., PMID:38787349
Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model., PMID:38582897
Mammalian Diaphanous1 signalling in neurovascular complications of diabetes., PMID:38491850
Integrated analysis of transcriptome and genome variations in pediatric T cell acute lymphoblastic leukemia: data from north Indian tertiary care center., PMID:38459434
DIAPH1-MFN2 interaction decreases the endoplasmic reticulum-mitochondrial distance and promotes cardiac injury following myocardial ischemia., PMID:38368414
KIF20B and MET, hub genes of DIAPHs, predict poor prognosis and promote pancreatic cancer progression., PMID:38266456
Using meta-analysis and machine learning to investigate the transcriptional response of immune cells to Leishmania infection., PMID:38190401
DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress., PMID:37903764
Disruption of the productive encounter complex results in dysregulation of DIAPH1 activity., PMID:37832872
An Extended Iranian Family with Autosomal Dominant Non-syndromic Hearing Loss Associated with A Nonsense Mutation in the DIAPH1 Gene., PMID:37543941
Novel insights into the nervous system affected by prolonged hyperglycemia., PMID:37462767
Association between DIAPH1 variant and posterior circulation involvement with Moyamoya disease., PMID:37400591
A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease., PMID:37265567
Actin nucleators safeguard replication forks by limiting nascent strand degradation., PMID:37224534
Monogenic Causes of Low-Frequency Non-Syndromic Hearing Loss., PMID:37121227
New insights into RAGE/Diaph1 interaction as a modulator of actin cytoskeleton dynamics in peripheral nervous system in long-term hyperglycaemia., PMID:37070486
Novel WFS1 mutations in patients with low-to-middle frequency hearing loss., PMID:36958120
DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice., PMID:36932214
Actin nucleators safeguard replication forks by limiting nascent strand degradation., PMID:36711944
In-depth genetic and molecular characterization of diaphanous related formin 2 (DIAPH2) and its role in the inner ear., PMID:36689403
Diaphanous-related formin subfamily: Novel prognostic biomarkers and tumor microenvironment regulators for pancreatic adenocarcinoma., PMID:36589226
Formin protein DIAPH1 positively regulates PD-L1 expression and predicts the therapeutic response to anti-PD-1/PD-L1 immunotherapy., PMID:36503156
The RAGE/DIAPH1 axis: mediator of obesity and proposed biomarker of human cardiometabolic disease., PMID:36448548
For research use only. Not for human or drug use.
