Catalog No.
YHA85301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile229-Val465
Predicted molecular weight
29.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60260
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Parkin, PARK2, Parkinson juvenile disease protein 2, E3 ubiquitin-protein ligase parkin, Parkin RBR E3 ubiquitin-protein ligase, PRKN, Parkinson disease protein 2
Baoshentongluo Formula relieves podocyte injury in diabetic kidney disease through regulating mitophagy via PINK1/Parkin signaling pathway., PMID:40487763
Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway., PMID:40485166
Rare Copy Number Variants Intersecting Parkinson's-associated Genes in a Cohort of children With Autism Spectrum Disorders., PMID:40474964
The Developing Retina Undergoes Mitochondrial Remodeling via PINK1/PRKN-dependent Mitophagy., PMID:40472989
Mitochondria-centred metabolomic map of inclusion body myositis: sex-specific alterations in central carbon metabolism., PMID:40450407
Proteomics based discovery of Salvia miltiorrhiza Bunge treating Parkinson's disease through the PINK1/Parkin pathway., PMID:40456474
Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting Mitofusin 2., PMID:40444323
Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway., PMID:40441663
Hyperbaric oxygen therapy attenuates carbon monoxide-induced lung injury by restoring mitochondrial dynamics and suppressing Pink1/Parkin-mediated mitophagy., PMID:40441279
Impaired Mitophagy Contributes to Pyroptosis in Sarcopenic Obesity Zebrafish Skeletal Muscle., PMID:40431451
Low Fluoride Regulates Macrophage Polarization Through Mitochondrial Autophagy Mediated by PINK1/Parkin Axis., PMID:40427540
The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson's Disease., PMID:40427510
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy., PMID:40409109
Enterovirus 71 Induces Mitophagy via PINK1/Parkin Signaling Pathway to Promote Viral Replication., PMID:40396408
High fat diet (HFD) induced hepatic lipogenic metabolism and lipotoxicity via Parkin-dependent mitophagy and Errα signal of Pelteobagrus fulvidraco., PMID:40394711
PINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice., PMID:40373838
The role of dopaminergic medication and specific pathway alterations in idiopathic and PRKN/PINK1-mediated Parkinson's disease., PMID:40367158
Isolation and Characterization of Earthworm Peptides with Neuroprotective Effects in Parkinson's Disease Models., PMID:40363759
DUT (p.Y116C)-Mutation-Induced Thrombocytopenia in Rabbits., PMID:40362420
Vital Role of PINK1/Parkin-Mediated Mitophagy of Pulmonary Epithelial Cells in Severe Pneumonia Induced by IAV and Secondary Staphylococcus aureus Infection., PMID:40362402
Daidzein Attenuates Cadmium-Induced Neurotoxicity via Inhibiting Apoptosis and Mitophagy in the Cerebral Cortex of Sprague-Dawley Rats., PMID:40358926
Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy., PMID:40348769
Verbenalin protects against coronavirus pneumonia by promoting host immune homeostasis: Evidences for its mechanism of action., PMID:40347923
Mechanism of SMYD2 promoting stemness maintenance of bladder cancer stem cells by regulating PYCR1 expression and PINK1/Parkin mitophagy pathway., PMID:40341538
FB1 causes barrier damage to vascular endothelial cells through ferroptosis by a PINK1/Parkin mediated mitophagy-dependent mechanism., PMID:40324642
Retroviral foamy virus gag induces parkin-dependent mitophagy., PMID:40317036
USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer., PMID:40316942
Genome-wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease., PMID:40309932
Dendrobine attenuates sepsis-associated acute kidney injury by promoting PINK1/PARKIN-mediated mitophagy., PMID:40306112
Cynaropicrin Suppresses Cell Proliferation by Inducing Mitophagy through p38 MAPK-Mediated Mitochondrial ROS Generation in Human Hepatocellular Carcinoma Cells., PMID:40295200
Neferine Ameliorates Slow-Transmitting Constipation by Inducing PINK1/Parkin-Mediated Mitophagy in Protective Enteric Glial Cells., PMID:40295194
l-Carnitine and Acetyl-l-Carnitine Induce Metabolism Alteration and Mitophagy-Related Cell Death in Colorectal Cancer Cells., PMID:40290068
VDAC1 Inhibition Protects Against Noise-Induced Hearing Loss via the PINK1/Parkin Pathway., PMID:40285415
Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson's Disease., PMID:40282414
Immunohistochemical Expression of PARK2 and YAP in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma., PMID:40279065
Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress., PMID:40278296
Pathogenetic Involvement of Autophagy and Mitophagy in Primary Progressive Multiple Sclerosis., PMID:40257374
Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy., PMID:40253768
TJ0113 attenuates fibrosis in metabolic dysfunction-associated steatohepatitis by inducing mitophagy., PMID:40252468
High Agreement Across Laboratories Between Different Alpha-Synuclein Seed Amplification Protocols., PMID:40237217
High glucose induces senescence in synovial mesenchymal stem cells through mitochondrial dysfunction., PMID:40234847
USP7 promotes PINK1/Parkin-dependent mitophagy to ameliorate cerebral ischemia-reperfusion injury by deubiquitinating and stabilizing SIRT1., PMID:40216374
Bazibushen attenuates fibroblast senescence in silica-induced pulmonary fibrosis via FOXO1/PINK1/Parkin Axis., PMID:40215811
Curcumin alleviates atrazine-induced nephrotoxicity by enhancing mitophagy through PINK1/Parkin signaling pathway in mice., PMID:40209350
Plasma and urinary metabolomic signatures differentiate genetic and idiopathic Parkinson's disease., PMID:40204143
Urolithin A enhances diabetic wound healing: Insights from parkin-mediated mitophagy in endothelial progenitor cells., PMID:40203794
The effective-compound compatibility of JHF inhibits fibroblast activation in pulmonary fibrosis by enhancing PINK1/PARK2-mediated mitophagy., PMID:40200051
BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammation., PMID:40195021
TCE-mediated neuroprotection against rotenone-induced dopaminergic neuronal death in PD mice: insights into the Nrf-2/PINK1/Parkin-mitophagy pathway., PMID:40192858
For research use only. Not for human or drug use.
