Catalog No.
YHA75501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr611-Leu911
Predicted molecular weight
36.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43707
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH7.4,1mM EDTA, 4%trehalose,1% mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Non-muscle alpha-actinin 4, Alpha-actinin-4, ACTN4
Renal Dysfunction Induced by Sodium p-Perfluorous Nonenoxybenzenesulfonate in Mice: Insights from the Intrinsic Mechanisms of Proteinuria., PMID:40444664
Screening and identification of protein 29 of Echinococcus granulosus interacting molecules., PMID:40384981
Differential Genes Analysis and Validation of Disulfideptosis in Rat Myocardial Ischemia-Reperfusion Injury Model., PMID:40323799
Integrated bioinformatic analysis of immune infiltration and disulfidptosis related gene subgroups in type A aortic dissection., PMID:40258895
Triclosan-mediated metabolic oxidative stress-triggered cytoskeletal alterations in zebrafish gills and intestine: An integrated biomolecular and NMR-based metabolomics study., PMID:40239525
A Novel Gastrodin Derivative with Neuroprotection Promotes NGF-Mimic Activity by Targeting INSR and ACTN4 to Activate PI3K/Akt Signaling Pathway in PC12 Cells., PMID:40227445
Testicular stage- and cell-specific expression of F-actin binding proteins., PMID:40207874
Comprehensive Proteomics and Machine Learning Analysis to Distinguish Follicular Adenoma and Follicular Thyroid Carcinoma from Indeterminate Thyroid Nodules., PMID:40205804
Multi-omics integration identifies molecular markers and biological pathways for carcass and meat quality traits in Nellore cattle., PMID:40140445
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease., PMID:39918740
Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4., PMID:39907925
Identification of multicohort-based predictive signature for NMIBC recurrence reveals SDCBP as a novel oncogene in bladder cancer., PMID:39873429
DANCR knockdown alleviates neuroinflammation and functional recovery after spinal cord injury via regulating the ACTN4 / STAT3 axis., PMID:39798643
Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation., PMID:39760648
High MICAL-L2 promotes cancer progression and drug resistance in renal clear cell carcinoma cells through stabilization of ACTN4 following vimentin expression., PMID:39689763
Diagnostic and prognostic value of disulfidptosis-related genes in sepsis., PMID:39610785
METTL3-Dependent YTHDF2 Mediates TSC1 Expression to Regulate Alveolar Epithelial Mesenchymal Transition and Promote Idiopathic Pulmonary Fibrosis., PMID:39606797
Splicing dysregulation in glioblastoma alters the function of cell migration-related genes., PMID:39448549
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption., PMID:39446130
ADAR1 Promotes Myogenic Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells., PMID:39404371
Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2., PMID:39289355
Functional Insights in PLS3-Mediated Osteogenic Regulation., PMID:39273077
Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4., PMID:39263353
Discovery of Novel TULP4/ACTN4/EWSR1/ACTB::MYB and ESRRG::DNM3 Fusions Expands Molecular Landscape of Adenoid Cystic Carcinoma Beyond Fusions Between MYB/MYBL1 and NFIB Genes., PMID:39235305
Live-cell imaging and CLEM reveal the existence of ACTN4-dependent ruffle-edge lamellipodia acting as a novel mode of cell migration., PMID:39222868
Impact of maternal protein restriction on the proteomic landscape of male rat lungs across the lifespan., PMID:39218056
CCT3/ACTN4/TFRC axis protects hepatocellular carcinoma cells from ferroptosis by inhibiting iron endocytosis., PMID:39210442
MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation., PMID:39197582
KIAA1199/CEMIP knockdown attenuates cardiac remodeling post myocardial infarction by activating TSP4 pathway in mice., PMID:39173890
ACTN4 is associated with the malignant potential of thymic epithelial tumors through the β-catenin/Slug pathway., PMID:39166351
Nuclear α-actinin-4 regulates breast cancer invasiveness and EMT., PMID:39143850
The Immunosuppressive Drug LF15-0195 Acts Also on Glomerular Lesions, by a Change in Cytoskeleton Distribution in Podocyte., PMID:39074452
Identification of key genes involved in collagen hydrogel-induced chondrogenic differentiation of mesenchymal stem cells through transcriptome analysis: the role of m6A modification., PMID:39073623
Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer., PMID:39052867
Association of ACTN4 Gene Mutation with Primary Nephrotic Syndrome in Children in Guangxi Autonomous Region, China., PMID:38949978
AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells., PMID:38822246
URINARY EXCRETION OF ALPHA-ACTININ-4 AND TIGHT JUNCTION PROTEIN 1 IN PATIENTS WITH TYPE 2 DIABETES AND DIFFERENT PATTERNS OF CHRONIC KIDNEY DISEASE., PMID:38807395
m6A modification of lncRNA PHKA1-AS1 enhances Actinin Alpha 4 stability and promotes non-small cell lung cancer metastasis., PMID:38764726
Disulfidptosis-related signature elucidates the prognostic, immunologic, and therapeutic characteristics in ovarian cancer., PMID:38694875
Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer., PMID:38669694
KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma., PMID:38649438
Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain., PMID:38632655
Whole-Exome Sequencing (WES) Reveals Novel Sex-Specific Gene Variants in Non-Alcoholic Steatohepatitis (MASH)., PMID:38540416
A novel disulfidptosis-related prognostic gene signature and experimental validation identify ACTN4 as a novel therapeutic target in lung adenocarcinoma., PMID:38517776
Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors., PMID:38299456
Collapsing Glomerulopathy in a Patient with a TRPC6 Mutation Presenting as Rapidly Progressive Glomerulonephritis: A Case Report and Review of the Literature., PMID:38231721
Podocyte Infolding Glomerulopathy: A Special Morphology of Podocyte Injury Caused by Heterogeneous Diseases., PMID:38106587
Pan-cancer genetic analysis of disulfidptosis-related gene set., PMID:37879141
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway., PMID:37626047
Ocular manifestations of the genetic causes of focal and segmental glomerulosclerosis., PMID:37578539
For research use only. Not for human or drug use.
