Catalog No.
YHA67901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly7-Met271
Predicted molecular weight
33.27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43463
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Position-effect variegation 3-9 homolog, SUV39H, H3-K9-HMTase 1, SUV39H1, Histone-lysine N-methyltransferase SUV39H1, Su(var)3-9 homolog 1, Lysine N-methyltransferase 1A, Histone H3-K9 methyltransferase 1, Suppressor of variegation 3-9 homolog 1, KMT1A
Epigenetic regulation of histone methyltransferase SUV39H1 on the expression of recombinant protein in CHO cells., PMID:40347234
Suv39h1 Regulates Phenotypic Modulation of Smooth Muscle Cells and Contributes to Vascular Injury by Repressing HIC1 Transcription., PMID:40308197
Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone lysine methyltransferases and reduction of cccDNA., PMID:40270769
HELLS controls mitochondrial dynamics and genome stability in liver cancer by collusion with MIEF1., PMID:40175344
Pulsatile flow induces chromatin interaction with lamin-associated proteins to enrich H3K9 methylation in endothelial cells., PMID:40117319
SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma., PMID:40059829
Oridonin Preserves Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates Choroidal Neovascularization., PMID:39982392
Heterochromatic gene silencing controls CD4+ T cell susceptibility to regulatory T cell-mediated suppression in a murine allograft model., PMID:39794349
Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells., PMID:39705314
Novel role of zinc-finger protein 518 in heterochromatin formation on α-satellite DNA., PMID:39673523
Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid-Liquid Phase Separation and Ferroptosis-Related Genes., PMID:39635757
DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states., PMID:39631394
Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury., PMID:39603205
Cardiac-specific Suv39h1 knockout ameliorates high-fat diet induced diabetic cardiomyopathy via regulating Hmox1 transcription., PMID:39580141
The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy., PMID:39519018
Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation., PMID:39477922
The N6-methyladenosine landscape of ovarian development and aging highlights the regulation by RNA stability and chromatin state., PMID:39410722
SUV39H1 Regulates Gastric Cancer Progression via the H3K9me3/ALDOB Axis., PMID:39302619
SUV39H1 epigenetically modulates the MCPIP1-AURKA signaling axis to enhance neuroblastoma tumorigenesis., PMID:39300256
H3K9me3 Levels Affect the Proliferation of Bovine Spermatogonial Stem Cells., PMID:39273164
Mutual regulation between histone methyltransferase Suv39h1 and the Wnt/β-catenin signaling pathway promoted cell proliferation and inhibited apoptosis in bone marrow mesenchymal stem cells exposed to hydroquinone., PMID:39179171
METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation., PMID:39169036
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer., PMID:38976080
Targeting pericentric non-consecutive motifs for heterochromatin initiation., PMID:38961301
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation., PMID:38842922
Suv39h1: Targeting epigenetics to treat liver fibrosis., PMID:38822456
Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription., PMID:38719473
Maternal high fat diet programs spatial learning and central leptin signaling in mouse offspring in a sex-specific manner., PMID:38714271
Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma., PMID:38650654
HBV PreC interacts with SUV39H1 to induce viral replication by blocking the proteasomal degradation of viral polymerase., PMID:38628076
Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma., PMID:38424632
Epigenetic reprogramming of CAR T cells for in vivo functional persistence against solid tumors., PMID:38388813
Suv39h1 contributes to activation of hepatic stellate cells in non-alcoholic fatty liver disease by enabling anaerobic glycolysis., PMID:38340980
Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation., PMID:38309502
Regulation of adipogenesis by histone methyltransferases., PMID:38241884
Decoding the multifaceted interventions between human sirtuin 2 and dynamic hepatitis B viral proteins to confirm their roles in HBV replication., PMID:38239506
PTOV1-AS1 desensitizes colorectal cancer cells to 5-FU through depressing miR-149-5p to activate the positive feedback loop with Wnt/β-catenin pathway., PMID:38194947
Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis., PMID:38176898
Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells., PMID:38173411
Epigenetic modification of TWIST1 in macrophages promotes hypertension-induced atherosclerotic plaque instability., PMID:38134595
SUV39H1 is a novel biomarker targeting oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma., PMID:38017386
Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201., PMID:38011799
Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function., PMID:37934007
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors., PMID:37934001
TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation., PMID:37913773
SUV39H1 Expression as a Guideline for Omitting Radiotherapy in Lymph Node-positive Triple-negative Breast Cancer Patients., PMID:37889057
Enhanced Transcriptional Signature and Expression of Histone-Modifying Enzymes in Salivary Gland Tumors., PMID:37887281
DCAF13 and RNF114 participate in the regulation of early porcine embryo development., PMID:37855431
Prolonged Inhibition of the MEK1/2-ERK Signaling Axis Primes Interleukin-1 Beta Expression through Histone 3 Lysine 9 Demethylation in Murine Macrophages., PMID:37833877
SUV39H1 Inhibits Angiogenesis in Limb Ischemia of Mice., PMID:37811706
For research use only. Not for human or drug use.
