Catalog No.
YHA64701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu30-Thr285
Predicted molecular weight
31.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43318
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mitogen-activated protein kinase kinase kinase 7, TAK1, MAP3K7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1
Dihydrocapsaicin Enhances Tumor Necrosis Factor-α-Induced Apoptosis and G1 Cell Cycle Arrest in Human Cervical Cancer Cells Through TAK1-Mediated NF-κB and EGFR Pathways., PMID:40507823
Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice., PMID:40456736
ITGA5 drives angiogenesis in diabetic retinopathy via TAK-1/NF-kB activation., PMID:40410450
NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis., PMID:40349344
Deficiency of β-arrestin2 ameliorates MASLD in mice by promoting the activation of TAK1/AMPK signaling., PMID:40341987
Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway., PMID:40334945
IFITMs exhibit antiviral activity against Chikungunya and Zika virus infection via the alteration of TLRs and RLRs signaling pathways., PMID:40328864
[Disulfiram alleviates cardiac hypertrophic injury by inhibiting TAK1-mediated PANoptosis]., PMID:40326066
Understanding TAK1 deficiency in microglia: Dual mechanisms for photoreceptor protection in a mouse model of retinitis pigmentosa., PMID:40314985
Trim38 attenuates pressure overload‑induced cardiac hypertrophy by suppressing the TAK1/JNK/P38 signaling pathway., PMID:40314083
Autophagy is involved in Salmonella Typhimurium-induced ferroptosis in macrophages., PMID:40311251
Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells., PMID:40305047
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy., PMID:40303300
TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis., PMID:40266671
Nile tilapia P38 MAPK interacts with Tak1 and is involved in the immune response to Streptococcus agalactiae, PolyI:C, and LPS stimulation., PMID:40246037
Curcumol Ameliorates Cisplatin-induced Nephrotoxicity by Targeting TAK1 and Inhibiting MAPK and NF-κB Pathways., PMID:40222166
Exploring Genetic Factors Associated with Moniezia spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach., PMID:40150341
African swine fever virus I177L induces host inflammatory responses by facilitating the TRAF6-TAK1 axis and NLRP3 inflammasome assembly., PMID:40135893
Activation of toll-like receptor 2 promotes the expression of inflammatory mediators and cell proliferation of human polycystic kidney disease cells., PMID:40101851
Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1., PMID:40096087
RGMb drives macrophage infiltration to aggravate kidney disease., PMID:40080642
Effect of the CSFV NS5A protein on key proteins in the MAPK and PI3K-mTOR signaling pathways in porcine macrophages., PMID:40078537
Deubiquitinase Ubiquitin-Specific Protease 29 Ameliorates Pathological Cardiac Hypertrophy through Inhibiting Transforming Growth Factor β-Activated Kinase 1., PMID:40040611
Transforming Growth Factor-β-Activated Protein 1 (TAK1) Regulates Necroptosis in Age-Related Hearing Loss., PMID:40018883
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis., PMID:39987261
Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment., PMID:39983894
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development., PMID:39971907
USP48 inhibits colorectal cancer progression and promotes M1-like macrophage polarization by stabilizing TAK1., PMID:39971179
Targeting TAK1: Evolution of inhibitors, challenges, and future directions., PMID:39909209
Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance., PMID:39901302
Betaine-homocysteine methyltransferase attenuates liver ischemia-reperfusion injury by targeting TAK1., PMID:39854060
Downregulation of RSAD2 ameliorates keratinocyte hyperproliferation and skin inflammation in psoriasis via the TAK1/NF-κB axis., PMID:39848474
Design and Synthesis of Hederagenin Derivatives for the Treatment of Sepsis by Targeting TAK1 and Regulating the TAK1-NF-κB/MAPK Signaling., PMID:39817810
Silencing Map3k7 suppresses pyroptosis to alleviate bronchopulmonary dysplasia through inhibiting the TGF-β1/Smad3 pathway., PMID:39815896
Nedd4 family interacting protein 1 directly regulates the NF-κB signaling pathway without promoting the ubiquitination of Tak1 in Nile tilapia., PMID:39814245
The ethanolic extract of Rhaphidophora peepla prevents inflammation by inhibiting the activation of Syk/AKT/NF-κB and TAK1/MAPK/AP-1., PMID:39810338
Senescent retinal pigment epithelial cells promote angiogenesis in choroidal neovascularization via the TAK1/p38 MAPK pathway., PMID:39778673
Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway., PMID:39718561
IL-1β stimulates a novel axis within the NFκB pathway in endothelial cells regulated by IKKα and TAK-1., PMID:39710275
Astragaloside IV ameliorates atherosclerosis by targeting TAK1 to suppress endothelial cell proinflammatory activation., PMID:39706043
Neohesperidin Dihydrochalcone Alleviates Lipopolysaccharide-Induced Vascular Endothelium Dysfunction by Regulating Antioxidant Capacity., PMID:39699295
SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis., PMID:39680116
Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity., PMID:39653824
Identification of TAK-756, A Potent TAK1 Inhibitor for the Treatment of Osteoarthritis through Intra-Articular Administration., PMID:39576936
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy., PMID:39572783
Tak1 licenses mitochondrial transfer from astrocytes to POMC neurons to maintain glucose and cholesterol homeostasis., PMID:39565693
Proteomic analysis of the combined effects of cannabigerol and 3-O-ethyl ascorbic acid on kinase-dependent signalling in UVB-irradiated human keratinocytes., PMID:39537961
miR-128-3p suppresses tumor growth and enhances chemosensitivity in tongue squamous cell carcinoma through MAP2K7 targeting., PMID:39476205
Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024., PMID:39474417
Unraveling the proteomic signatures of coronary artery disease and hypercholesterolemia., PMID:39445733
For research use only. Not for human or drug use.
