Catalog No.
YHA62901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe252-Arg390
Predicted molecular weight
17.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43294
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Androgen receptor-associated protein of 55 kDa, Hydrogen peroxide-inducible clone 5 protein, Androgen receptor coactivator 55 kDa protein, ARA55, Hic-5, Transforming growth factor beta-1-induced transcript 1 protein, TGFB1I1
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing., PMID:39494341
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions., PMID:39106080
A comparative analysis of paxillin and Hic-5 proximity interactomes., PMID:38801098
Hic-5 regulates extracellular matrix-associated gene expression and cytokine secretion in cancer associated fibroblasts., PMID:38237846
Paxillin family proteins Hic-5 and LPXN promote lipid storage by regulating the ubiquitination degradation of CIDEC., PMID:38159847
Vitamin D3 analogue calcipotriol inhibits the profibrotic effects of transforming growth factor- β1 on pancreatic stellate cells., PMID:37604222
Construction and experimental validation of a macrophage cell senescence-related gene signature to evaluate the prognosis, immunotherapeutic sensitivity, and chemotherapy response in bladder cancer., PMID:37423913
Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy., PMID:37371044
Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13., PMID:37156857
Rewiring of miRNA-mRNA bipartite co-expression network as a novel way to understand the prostate cancer related players., PMID:37018429
Candidate Genes and Gene Networks Change with Age in Japanese Black Cattle by Blood Transcriptome Analysis., PMID:36833431
A Bioinformatics Perspective on the Dysregulation of Ferroptosis and Ferroptosis-related Immune Cell Infiltration in Alzheimer's Disease., PMID:36438927
Histone acetyltransferase inhibition reverses opacity in rat galactose-induced cataract., PMID:36417410
Biomarkers of Periodontitis and Its Differential DNA Methylation and Gene Expression in Immune Cells: A Systematic Review., PMID:36233348
Bioinformatics Profiling and Experimental Validation of 4 Differentially-Expressed LIM Genes in the Course of Colorectal-Adenoma-Carcinoma., PMID:35854639
Candidate genes for polycystic ovary syndrome are regulated by TGFβ in the bovine foetal ovary., PMID:35413103
Evaluation of PGP 9.5, NGFR, TGFβ1, FGFR1, MMP-2, AT2R2, SHH, and TUNEL in Primary Obstructive Megaureter Tissue., PMID:34915763
Exosomal miR-193b-5p as a regulator of LPS-induced inflammation in dairy cow mammary epithelial cells., PMID:34312802
Network-based identification of key master regulators associated with an immune-silent cancer phenotype., PMID:33979427
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway., PMID:33310972
Hic-5 is required for activation of pancreatic stellate cells and development of pancreatic fibrosis in chronic pancreatitis., PMID:33154390
Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion., PMID:32859368
TGFβ1I1 suppressed cell migration and invasion in colorectal cancer by inhibiting the TGF-β pathway and EMT progress., PMID:32706067
Analysis of expression of candidate genes for polycystic ovary syndrome in adult and fetal human and fetal bovine ovaries†., PMID:32678441
Increased expression of the transforming growth factor β-inducible gene HIC-5 in systemic sclerosis skin and fibroblasts: a novel antifibrotic therapeutic target., PMID:32442272
Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways., PMID:32147431
Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-κB (p65)/IL-6 signalling pathway., PMID:31797546
GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells., PMID:31760076
HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression., PMID:31740661
Hic-5 in pancreatic stellate cells affects proliferation, apoptosis, migration, invasion of pancreatic cancer cells and postoperative survival time of pancreatic cancer., PMID:31683179
Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5., PMID:31673109
The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts., PMID:31644368
The Leptin induced Hic-5 expression and actin puncta formation by the FAK/Src-dependent pathway in MCF10A mammary epithelial cells., PMID:31584768
PTHR1 May Be Involved in Progression of Osteosarcoma by Regulating miR-124-3p-AR-Tgfb1i1, miR-27a-3p-PPARG-Abca1, and miR-103/590-3p-AXIN2 Axes., PMID:31536386
Hic-5 regulates Src-induced invadopodia rosette formation and organization., PMID:30893012
Transcript abundance of stromal and thecal cell related genes during bovine ovarian development., PMID:30856218
Regulation of mitochondrial ROS production by HIC-5: a common feature of oncogene-induced senescence and tumor invasiveness?, PMID:30680933
A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells., PMID:30281903
Quantitative Proteomics Implicates Rictor/mTORC2 in Cell Adhesion., PMID:30156101
RETRACTED: Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells by inhibiting expression of miR-124., PMID:29990829
RETRACTED: TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells., PMID:29864957
Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices., PMID:29771639
Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1., PMID:29348458
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling., PMID:29242607
Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner., PMID:29137281
Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation., PMID:28935710
IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5., PMID:28612841
The adaptor protein ARA55 and the nuclear kinase HIPK1 assist c-Myb in recruiting p300 to chromatin., PMID:28495617
RAGE-mediated extracellular matrix proteins accumulation exacerbates HySu-induced pulmonary hypertension., PMID:28407046
Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes., PMID:28381557
For research use only. Not for human or drug use.
