Catalog No.
YHA59501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg73-Ile255
Predicted molecular weight
23.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43174
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
P450RAI1, Cytochrome P450 26A1, Cytochrome P450RAI, hP450RAI, CYP26A1, Cytochrome P450 retinoic acid-inactivating 1, Retinoic acid-metabolizing cytochrome, CYP26, Retinoic acid 4-hydroxylase
Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration., PMID:40494878
Effect of MiRNA 204-5P Mimics and Lipopolysaccharide-Induced Inflammation on Transcription Factor Levels, Cell Maintenance, and Retinoic Acid Signaling in Primary Limbal Epithelial Cells., PMID:40332443
Retinoic acid receptor-β deletion in a model of early pancreatic ductal adenocarcinoma (PDAC) tumorigenesis., PMID:39949931
Meiosis and retinoic acid in the mouse fetal gonads: An unforeseen twist., PMID:39870439
Genetic and metabolic factors influencing skin yellowness in yellow-feathered broilers., PMID:39561557
Identification and Verification of Potential Markers Related to Myocardial Fibrosis by Bioinformatics Analysis., PMID:39387979
Enhancing Retinoic Acid-mediated Effects Through Inhibition of CYP26A1, CYP26B1 and HGF Signaling in Neuroblastoma Cells., PMID:39348986
Asprosin regulates male reproduction in teleosts: an in vitro study in Channa punctata., PMID:39302003
Screening (ant)agonistic activities of xenobiotics on the retinoic acid receptor alpha (RARα) using in vitro and in silico analysis., PMID:38997027
Seasonal changes in vitamin A metabolism-related factors in the oviduct of Chinese brown frog (Rana dybowskii)., PMID:38992392
Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving., PMID:38935096
Development and validation of CYP26A1 inhibition assay for high-throughput screening., PMID:38863121
Gonadal Transcriptome Analysis Reveals that SOX17 and CYP26A1 are Involved in Sex Differentiation in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)., PMID:38710962
LX-2 Stellate Cells Are a Model System for Investigating the Regulation of Hepatic Vitamin A Metabolism and Respond to Tumor Necrosis Factor α and Interleukin 1β., PMID:38485281
Attenuated retinoic acid signaling is among the early responses in mouse uterus approaching embryo attachment., PMID:38404366
Genetic Biomarkers of Sorafenib Response in Patients with Hepatocellular Carcinoma., PMID:38396873
Identification of an inflammation-related risk signature for prognosis and immunotherapeutic response prediction in bladder cancer., PMID:38216619
Expression patterns of CYP26A1, FGF8, CDKN1A, and NPVF in the developing rhesus monkey retina., PMID:38147763
[Change of the retinoic acid pathway in hypothalamus and pituitary damage induced by combined exposure to low-level Pb~(2+) and 1-nitropyrene in mice]., PMID:38115665
Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8+ T cells., PMID:37997519
CLMP is a tumor suppressor that determines all-trans retinoic acid response in colorectal cancer., PMID:37944525
Elongation of the developing spinal cord is driven by Oct4-type transcription factor-mediated regulation of retinoic acid signaling in zebrafish embryos., PMID:37850839
CYP26B1-related disorder: expanding the ends of the spectrum through clinical and molecular evidence., PMID:37755482
Mechanism of thyroid hormone and its structurally similar contaminant bisphenol S exposure on retinoid metabolism in zebrafish larval eyes., PMID:37748373
Neural plate progenitors give rise to both anterior and posterior pituitary cells., PMID:37683631
Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain., PMID:37639183
Hyperglycemia alters retinoic acid catabolism in embryos exposed to a maternal diabetic milieu., PMID:37616226
Colitis-Mediated Dysbiosis of the Intestinal Flora and Impaired Vitamin A Absorption Reduce Ovarian Function in Mice., PMID:37299390
Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (RARβ) Gene in Hepatocytes., PMID:37239961
Familial monoallelic CYP26B1 truncating variant causes a syndromic craniosynostosis due to haploinsufficiency ?, PMID:37100236
Elevated expression of endocan in the development of cervical squamous neoplasia of the uterus., PMID:37074500
A variant in CYP26B1 associated with esophageal squamous cell carcinoma risk by affecting retinoic acid metabolism., PMID:37042568
Genetic linkage analysis of head and neck cancer in a Spanish family., PMID:37026679
Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control., PMID:37011860
Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro., PMID:36805303
A Functional Polymorphism Downstream of Vitamin A Regulator Gene CYP26B1 Is Associated with Hand Osteoarthritis., PMID:36769350
Retinoic acid metabolism in cancer: potential feasibility of retinoic acid metabolism blocking therapy., PMID:36592231
Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumours in dogs and identifies CYP26B1 as a potential new therapeutic target., PMID:36582114
Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression., PMID:36301364
In Vitro Transfection of Up-Regulated Genes Identified in Favorable-Outcome Neuroblastoma into Cell Lines., PMID:36231133
Distinctive Metabolism-Associated Gene Clusters That Are Also Prognostic in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma., PMID:36199423
All-trans Retinoic Acid has Limited Therapeutic Effects on Cognition and Hippocampal Protein Expression After Controlled Cortical Impact., PMID:35878718
TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells., PMID:35831557
The glucocorticoid receptor represses, whereas C/EBPβ can enhance or repress CYP26A1 transcription., PMID:35789854
CYP26A1 Is a Novel Cancer Biomarker of Pancreatic Carcinoma: Evidence from Integration Analysis and In Vitro Experiments., PMID:35707714
Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells., PMID:35650141
Pesticides Inhibit Retinoic Acid Catabolism in PLHC-1 and ZFL Fish Hepatic Cell Lines., PMID:35608517
CRABPs Alter all-trans-Retinoic Acid Metabolism by CYP26A1 via Protein-Protein Interactions., PMID:35565751
Retinol Binding Protein 7 Promotes Adipogenesis in vitro and Regulates Expression of Genes Involved in Retinol Metabolism., PMID:35493071
Endothelial Cyp26b1 restrains murine heart valve growth during development., PMID:35364055
For research use only. Not for human or drug use.
