Catalog No.
YHA53601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser207-Glu520
Predicted molecular weight
38.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15460
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
P4HA2, 4-PH alpha-2, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2, Prolyl 4-hydroxylase subunit alpha-2
Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway., PMID:40379610
Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study., PMID:40347062
Comprehensive analysis of the effects of P4ha1 and P4ha2 deletion on post-translational modifications of fibrillar collagens in mouse skin., PMID:40092628
Protein disulfide isomerase is essential for osteoblast differentiation in mice., PMID:40065084
Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis., PMID:39920992
YTHDF3-induced degradation of P4HA2 mRNA inhibits glycolysis in papillary thyroid cancer through Hippo signaling pathway., PMID:39725111
Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis., PMID:39693409
P4HA2 knockdown prevents the progression of intracranial aneurysm by inducing prolyl hydroxylation of YAP1., PMID:39560705
Letters to editor regarding the article "P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway"., PMID:39136825
P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma., PMID:38951593
P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression., PMID:38909089
P4HA2 promotes tumor progression and is transcriptionally regulated by SP1 in colorectal cancer., PMID:38857058
Comprehensive analysis revealed P4Hs as new biomarkers for prognosis and immunotherapy in head and neck cancer., PMID:38806556
P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway., PMID:38777998
P4HA2 activates mTOR via hydroxylation and targeting P4HA2-mTOR inhibits lung adenocarcinoma cell growth., PMID:38654109
GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement., PMID:38643161
P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer., PMID:38522060
TMT quantitative proteomics reveals key proteins relevant to microRNA-1-mediated regulation in osteoarthritis., PMID:37993861
Comprehensive In silico analysis of chaperones identifies CRYAB and P4HA2 as potential therapeutic targets and their small-molecule inhibitors for the treatment of cholangiocarcinoma., PMID:37844407
The role of vesicle trafficking genes in osteoblast differentiation and function., PMID:37752218
Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells., PMID:37561833
P4HA2-induced prolyl hydroxylation of YAP1 restricts vascular smooth muscle cell proliferation and neointima formation., PMID:37549826
The Role of SOX9 in IGF-II-Mediated Pulmonary Fibrosis., PMID:37510994
Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression., PMID:37248456
Tissue-specific collagen hydroxylation at GEP/GDP triplets mediated by P4HA2., PMID:37003347
Mutational investigation of 17 causative genes in a cohort of 113 families with nonsyndromic early-onset high myopia in northwestern China., PMID:36964802
P4HA2-mediated HIF-1α stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer., PMID:36943397
Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study., PMID:36918797
CEBPB upregulates P4HA2 to promote the malignant biological behavior in IDH1 wildtype glioma., PMID:36906285
Identification of the core genes in Randall's plaque of kidney stone and immune infiltration with WGCNA network., PMID:36816033
P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases., PMID:36799463
Cycloheximide promotes type I collagen maturation mainly via collagen prolyl 4-hydroxylase subunit α2., PMID:36789685
Identifying the mechanisms and molecular targets of Hongjingtian injection on treatment of TGFβ1-induced HK-2 cells: coupling network pharmacology with experimental verification., PMID:36660701
Transcriptome analysis of a dog model of congestive heart failure shows that collagen-related 2-oxoglutarate-dependent dioxygenases contribute to heart failure., PMID:36581661
High expression of prolyl 4-hydroxylase subunit alpha-2 in lung adenocarcinoma indicates poor prognosis., PMID:36403427
A review on the role of PCGEM1 lncRNA in cancer., PMID:36403313
Generation of a homozygous P4HA2 knockout human embryonic stem cell line (FDCHDPe012-A) by CRISPR/Cas9 system., PMID:36206672
Exposure to nanographene oxide induces gene expression dysregulation in normal human astrocytes., PMID:35843713
[P4HA2 promotes occurrence and progression of liver cancer by regulating the PI3K/Akt/mTOR signaling pathway]., PMID:35673909
Mutational screening of AGRN, SLC39A5, SCO2, P4HA2, BSG, ZNF644, and CPSF1 in a Chinese cohort of 103 patients with nonsyndromic high myopia., PMID:35002215
P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis., PMID:34471235
Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer., PMID:34387118
Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth., PMID:34218269
P4HA2 promotes cell proliferation and migration in glioblastoma., PMID:34188703
Collagen prolyl 4-hydroxylases modify tumor progression., PMID:34009234
The enzymatic hydrolysates from deer sinew promote MC3T3-E1 cell proliferation and extracellular matrix synthesis by regulating multiple functional genes., PMID:33568122
Comprehensive analysis of partial epithelial mesenchymal transition-related genes in hepatocellular carcinoma., PMID:33215860
Superoxide-induced Type I collagen secretion depends on prolyl 4-hydroxylases., PMID:32819558
LncRNA PCGEM1 enhances metastasis and gastric cancer invasion through targeting of miR-129-5p to regulate P4HA2 expression., PMID:32622013
Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5' Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis., PMID:32365562
For research use only. Not for human or drug use.
