Catalog No.
YHA51401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp142
Predicted molecular weight
18.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15392
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BIRC5, IAP4, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, API4, Baculoviral IAP repeat-containing protein 5
Lovastatin Targets the USP14-Survivin Axis to Suppress Triple-Negative Breast Cancer via Ubiquitin-Mediated Proteasomal Degradation., PMID:40497992
Unveiling the Therapeutic Potential of Targeting RRM2 in Hepatocellular Carcinoma: An Integrated In Silico and In Vitro Study., PMID:40493217
OZ-001 Suppresses the Growth of Triple-Negative Breast Cancer and Pancreatic Cancer by Targeting STAT3 Phosphorylation and the Calcium Signaling Pathway., PMID:40492404
Intranasal and Intravenous Sequential Administration of Survivin Peptide-CpG Nanovaccines Elicits Potent Immunity Toward Glioblastoma., PMID:40489066
Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors., PMID:40484644
DNA vaccination combined with immune checkpoint inhibition eradicates tumors, inducing life-long immunity against breast cancer in mice., PMID:40483788
Survivin knockout attenuates the progressiveness of BT549 triple negative-breast cancer cells: an in vitro study highlighting stemness and cellular stress response mechanisms., PMID:40478482
Targetable BIRC5 dependency in therapy-resistant TP53 mutated acute myeloid leukemia., PMID:40475516
Survivin modulates stiffness-induced vascular smooth muscle cell motility., PMID:40475264
Integrative in silico analysis of per- and polyfluorinated alkyl substances (PFAS)-associated molecular alterations in human cancers: a multi-cancer framework for predicting toxicogenomic disruption., PMID:40474796
BIRC5 as a master regulator in HCC: unraveling its role in tumor survival and therapeutic potential., PMID:40471223
The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin., PMID:40467895
An immune-related signature based on molecular subtypes for predicting the prognosis and immunotherapy efficacy of hepatocellular carcinoma., PMID:40458412
Engineered Nanoparticles for μPAD Nucleic Acid Detection., PMID:40454060
Construction of Cationic Carbon Dots Carrying Survivin siRNA Delivery System and Its Active Targeting Therapy for Liver Cancer., PMID:40452787
Ameliorative effect of Astaxanthin on DMBA-induced breast cancer in female rats: Interplay between Notch-1 and related miRNAs., PMID:40447066
A urine survivin (BIRC5) bioluminescence-based immunoassay., PMID:40443134
Combination therapy of avutometinib and MRTX1133 synergistically suppresses cell growth by inducing apoptosis in KRASG12D-mutated pancreatic cancer., PMID:40439998
Survivin (BIRC5) Gene Polymorphism (rs9904341) Is Associated with Cancer Risk: A Meta-Analysis., PMID:40439361
The role of statins in the regulation of breast and colorectal cancer and future directions., PMID:40438592
BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress., PMID:40436896
Evaluation of 'Cytorisk Index' (IL-6*survivin/IL-4 ratio) as a predictor of tumour aggression in breast cancer., PMID:40435911
Lipid-Coated Ag@MnO2 Core-Shell Nanoparticles for Co-Delivery of Survivin siRNA in Breast Tumor Therapy., PMID:40433119
Survivin Interference and SurVaxM as an Adjunct Therapy for Glioblastoma Multiforme., PMID:40422257
Design, synthesis, and activity evaluation of Asiatic acid derivatives as Survivin inhibitors., PMID:40414314
Evernic Acid: A Low-Toxic and Selective Alternative to Chemotherapeutic Agents in the Treatment of Ovarian Cancer., PMID:40405479
Effect of human survivin-2B-specific cytotoxic CD8+ T lymphocytes on CD44+/- HSC-2 and HSC-3 oral cancer cells., PMID:40399621
Cancer-associated fibroblast-derived fibulin-5 promotes epithelial-mesenchymal transition in diffuse-type gastric cancer via cAMP response element-binding protein pathway, showing poor prognosis., PMID:40369121
Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder., PMID:40367801
Epigenetic Silencing of miR-218-5p Modulates BIRC5 and DDX21 Expression to Promote Colorectal Cancer Progression., PMID:40362385
Five Cellular Genes as Candidates for Cervical Adenocarcinoma Molecular Markers., PMID:40361484
[Effect of Biyan Jiedu Capsules on proliferation and apoptosis of nasopharyngeal carcinoma cells based on PI3K/Akt pathway]., PMID:40350884
c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling., PMID:40350071
Poly(2-(diethylamino)ethyl methacrylate)-Functionalized Carbon Nanodots as Theranostic Platforms for siRNA Delivery and Survivin Silencing in Triple-Negative Breast Cancer., PMID:40347142
Seminal Plasma Survivin in Fertile and Infertile Males: Erratum., PMID:40340454
Overcoming Photothermal Resistance of Gastric Cancer by Bionic 2D Iron-Based Nanoplatforms with Precise CRISPR/Cas9 Delivery., PMID:40340328
Sinularin induces autophagy-dependent cell death by activating ULK1 and enhancing FOXO3-ATG4A axis in prostate cancer cells., PMID:40335577
Novel dihydrochalcone from Fissistigma latifolium targets STAT3 and survivin to overcome multidrug resistance cancers in vitro and in vivo., PMID:40327991
[Molecular Mechanism of Thymoquinone Inhibition on Malignant Proliferation of Acute Myeloid Leukemia Cells]., PMID:40326098
Targeting Triple-Negative Breast Cancer: Resistance Mechanisms and Therapeutic Advancements., PMID:40318146
Identification and validation of susceptibility modules and hub genes of adrenocortical carcinoma through WGCNA and machine learning., PMID:40317315
Phosphatidylinositol 3-Kinase Signaling Enhances Intestinal Crypt Epithelial Cell Recovery after Radiation., PMID:40316215
A comprehensive review and in silico analysis of the role of survivin (BIRC5) in hepatocellular carcinoma hallmarks: A step toward precision., PMID:40306500
Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy., PMID:40300855
Nanobody-based double antibody sandwich colloidal gold test strips for rapid detection of urinary biomarkers NMP22 and survivin in bladder cancer., PMID:40300312
Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets., PMID:40299210
In Silico Molecular Docking of 2-Hydroxyanthraquinone-Substituted Spiro-/Ansa Cyclotriphosphazenes: Targeting Apoptosis via Heat Shock Protein Modulation in Breast and Colon Cancer Cells., PMID:40296721
Naphthalimide derivative attenuates tumor growth of wild-type p53-expressing U87 glioma cells in vitro and in vivo through a biphasic dose-dependent mechanism: A switch from cell cycle to apoptosis., PMID:40294493
Anti-neoplastic activity of celastrol in experimentally-induced mammary adenocarcinoma in mice: targeting wnt/β-catenin signaling pathway., PMID:40293499
Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth., PMID:40293279
For research use only. Not for human or drug use.
