Catalog No.
YHA49701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser14-Ala176
Predicted molecular weight
20.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15347
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HMG-4, High mobility group protein 2a, HMG2A, HMG4, HMGB3, High mobility group protein 4, High mobility group protein B3, HMG-2a
Overview of high mobility group box 3 (HMGB3] protein., PMID:40498374
Thermal acclimatization mechanisms in the cold-water Ophiuroid Ophiura sarsii vadicola: Regulation of protein homeostasis and metabolic pathways., PMID:40413918
Comprehensive bioinformatics analysis identified HMGB3 as a promising immunotherapy target for glioblastoma multiforme., PMID:40192954
Hsa_circ_0004662 Accelerates the Progression of Ulcerative Colitis via the microRNA-532/HMGB3 Signalling Axis., PMID:40099942
Identification of increased dedifferentiation along the Prom1+ cancer cells in Müllerian adenosarcoma with sarcomatous overgrowth., PMID:39920368
HOXA11-As Promotes Lymph Node Metastasis Through Regulation of IFNL and HMGB Family Genes in Pancreatic Cancer., PMID:39684631
HMGB3 Contributes to Anti-PD-1 Resistance by Inhibiting IFN-γ-Driven Ferroptosis in TNBC., PMID:39660968
ELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells through the HMGB3/β-catenin axis., PMID:39390359
HMGB3 and SUB1 Bind to and Facilitate the Repair of N2-Alkylguanine Lesions in DNA., PMID:39101269
Structure and Functions of HMGB3 Protein., PMID:39062899
Exosomal HMGB3 released by glioma cells confers the activation of NLRP3 inflammasome and pyroptosis in tumor-associated macrophages., PMID:38761792
EZH2 Promotes Glioma Cell Proliferation, Invasion, and Migration via Mir-142-3p/KCNQ1OT1/HMGB3 Axis : Running Title: EZH2 Promotes Glioma cell Malignant Behaviors., PMID:38556567
circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3., PMID:38226841
Translocated HMGB3 is involved in papillary thyroid cancer progression by activating cytoplasmic TLR3 and transmembrane TREM1., PMID:38197217
The expression of high mobility group protein 3 (HMGB3) in breast cancer with emphasis on its role in lymphovascular invasion., PMID:38058796
Novel mutations of the X-linked genes associated with early-onset high myopia in five Chinese families., PMID:37749571
Circ_LDLR promotes the progression of papillary thyroid carcinoma by regulating miR-1294/HMGB3 axis., PMID:37565296
CircRUNX1 drives the malignant phenotypes of lung adenocarcinoma through mediating the miR-5195-3p/HMGB3 network., PMID:37474742
Involvement of HIF1α/Reg protein in the regulation of HMGB3 in myocardial infarction., PMID:37467910
CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway., PMID:37359246
Significance of liquid-liquid phase separation (LLPS)-related genes in breast cancer: a multi-omics analysis., PMID:37338518
HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway., PMID:37328851
Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone Heteractis magnifica., PMID:37235375
CIRCULAR RNA CIRC_0099188 CONTRIBUTES TO LPS-INDUCED HPAEpiC CELL INJURY BY TARGETING THE MIR-1236-3P/HMGB3 AXIS., PMID:36802224
Overexpression of HMGB3 and its prognostic value in breast cancer., PMID:36620553
Tanshinone IIA (TSIIA) represses the progression of non-small cell lung cancer by the circ_0020123/miR-1299/HMGB3 pathway., PMID:36586093
FAIRE-MS reveals mitotic retention of transcriptional regulators on a proteome-wide scale., PMID:36583687
Expression, tumor immune infiltration, and prognostic impact of HMGs in gastric cancer., PMID:36568211
Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/β-Catenin Signal Pathway., PMID:36542208
SOX9 and HMGB3 co-operatively transactivate NANOG and promote prostate cancer progression., PMID:36541373
Trio-based exome sequencing broaden the genetic spectrum in keratoconus., PMID:36502923
HMGB3 Targeted by miR-145-5p Impacts Proliferation, Migration, Invasion, and Apoptosis of Breast Cancer Cells., PMID:36404911
Designing a humanized immunotoxin based on DELTA-stichotoxin-Hmg2a toxin: an in silico study., PMID:36400988
Construction and Validation of a Prognostic Model Based on mRNAsi-Related Genes in Breast Cancer., PMID:36267313
Overexpression of MiR-633 Suppresses the Tumorigenicity of Gastric Cancer Cells and Induces Apoptosis by Targeting MAPK1., PMID:36260266
Plasmacytoma variant translocation 1 inhibits miR-515-5p function and modulates high mobility group B3 to promote the growth of prostate cancer cells., PMID:36053124
Glaucocalyxin A Inhibits the Malignant Progression of Epithelial Ovarian Cancer by Affecting the MicroRNA-374b-5p/HMGB3/Wnt-β-Catenin Pathway Axis., PMID:35912216
Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma., PMID:35886008
The Crosstalk Between Immune Infiltration, Circulating Tumor Cells, and Metastasis in Pancreatic Cancer: Identification of HMGB3 From a Multiple Omics Analysis., PMID:35754798
HMGB3 inhibition by miR-142-3p/sh-RNA modulates autophagy and induces apoptosis via ROS accumulation and mitochondrial dysfunction and reduces the tumorigenic potential of human breast cancer cells., PMID:35753437
Long Noncoding RNA Brain Cytoplasmic RNA 1 Induces Cisplatin-Resistance of Cervical Cancer Cells by Sponging MicroRNA-330-5p and Upregulating High-Mobility Group Box 3., PMID:35705019
MicroRNA-18 facilitates the stemness of gastric cancer by downregulating HMGB3 though targeting Meis2., PMID:35416122
HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer., PMID:35332131
SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination., PMID:35073278
Circular RNA circFOXO3 facilitate non-small cell lung cancer progression through upregulating HMGB3 via sponging miR-545-3p/miR-506-3p., PMID:35038619
Differential proteomic analysis demonstrates follicle fluid participate immune reaction and protein translation in yak., PMID:35031034
miR-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical cancer cells., PMID:34973275
LINC00857 promotes colorectal cancer progression by sponging miR-150-5p and upregulating HMGB3 (high mobility group box 3) expression., PMID:34753396
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3., PMID:34408262
Circ_CLIP2 promotes glioma progression through targeting the miR-195-5p/HMGB3 axis., PMID:34357490
For research use only. Not for human or drug use.
