Catalog No.
YHA43901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser653-Asp862
Predicted molecular weight
26.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15169
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AXIN, Axin-1, hAxin, Axis inhibition protein 1, AXIN1
Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients., PMID:40481885
Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers., PMID:40442146
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance., PMID:40424469
High-Frequency Mutations in TP53, AXIN1, CTNNB1, and KRAS, and Polymorphisms in JAK1 Genes Among Mongolian HCC Patients., PMID:40344393
Unraveling the genetic underpinnings of mitochondrial traits and associated circulating inflammatory proteins in Alzheimer's disease: Mitochondrial HtrA2-T cell CD5 negative axis., PMID:40170213
Diabetic kidney disease: m6A modification as a marker of disease progression and subtype classification., PMID:40103797
Mitochondrial PGAM5 modulates methionine metabolism and feather follicle development by targeting Wnt/β-catenin signaling pathway in broiler chickens., PMID:40038789
Elaidic acid induces testicular oxidative stress, inflammation, Wnt/β-catenin disruption and abnormalities in steroidogenesis, spermatogenesis and histo-architecture in Sprague Dawley rats., PMID:40032023
Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ., PMID:39971912
Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis., PMID:39935472
Exploring the bidirectional relationships between alzheimer's disease and cerebral small vessel disease: Insights from mendelian randomization., PMID:39929297
High cumulative glucocorticoid dose is associated with increased levels of inflammation-related mediators in active rheumatoid arthritis., PMID:39744635
Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation., PMID:39741188
Loss of AXIN1 regulates response to lenvatinib through a WNT/KDM5B/p15 signalling axis in hepatocellular carcinoma., PMID:39653061
Investigating gene expression datasets of hippocampus tissue to discover Alzheimer's disease-associated molecular markers., PMID:39604273
AXIN2 is a non-redundant regulator of AXIN1 stability and β-catenin in colorectal cancer cells., PMID:39587396
Fatty acid synthase inhibition alleviates lung fibrosis via β-catenin signal in fibroblasts., PMID:39567194
Circulating inflammatory proteins are elevated in type 1 and type 2 diabetes and associated to complications., PMID:39562286
Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids., PMID:39487295
WTAP Promotes the Excessive Proliferation of Airway Smooth Muscle Cells in Asthma by Enhancing AXIN1 Levels Through the Recognition of YTHDF2., PMID:39453546
Exploring DIX-DIX Homo- and Hetero-Oligomers in Wnt Signaling with AlphaFold2., PMID:39404409
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation., PMID:39384753
Inflammation in liver fibrosis and atrial fibrillation: A prospective population-based proteomic study., PMID:39380717
Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath., PMID:39344774
Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites., PMID:39308524
TRIM59 is required for mouse GC-1 cell maintenance through modulating the ubiquitination of AXIN1., PMID:39263074
CasRx-based Wnt activation promotes alveolar regeneration while ameliorating pulmonary fibrosis in a mouse model of lung injury., PMID:39245939
Intracellular Construction of Organelle-like Compartments Facilitates Metabolic Flux in Escherichia coli., PMID:39230507
Dissecting the mediating role of inflammatory factors in the interaction between metabolites and sepsis: insights from bidirectional Mendelian randomization., PMID:39205680
A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway., PMID:39067696
Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies., PMID:39060515
Exploring causal correlations between circulating cytokines and atopic dermatitis: a bidirectional two-sample Mendelian randomization study., PMID:39055710
[Genetic drivers for inflammatory protein markers in colorectal cancer: a Mendelian randomization approach to clinical prognosis study]., PMID:39051082
Cribriform morular thyroid carcinoma: Clinicopathological and molecular basis for both a preventive and therapeutic approach for a rare tumor (Review)., PMID:39027989
AXIN2 promotes degradation of AXIN1 through tankyrase in colorectal cancer cells., PMID:39022865
Hypoxia exposure induces lactylation of Axin1 protein to promote glycolysis of esophageal carcinoma cells., PMID:38972426
A genome-wide screen links peroxisome regulation with Wnt signaling through RNF146 and TNKS/2., PMID:38967608
Cancer-associated fibroblasts-secreted exosomal miR-92a-3p promotes tumor growth and stemness in hepatocellular carcinoma through activation of Wnt/β-catenin signaling pathway by suppressing AXIN1., PMID:38949237
A Multiomic Analysis to Identify Drivers of Subclinical Vascular Disease in Systemic Lupus Erythematosus., PMID:38923259
Dicerandrol C Suppresses Proliferation and Induces Apoptosis of HepG2 and Hela Cancer Cells by Inhibiting Wnt/β-Catenin Signaling Pathway., PMID:38921589
AXIN1 mutations in nonsyndromic craniosynostosis., PMID:38905707
Investigating AXIN1 gene polymorphisms in Turkish children with cryptorchidism: A pilot study., PMID:38880668
Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling., PMID:38855175
Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines., PMID:38848383
Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma., PMID:38751441
The truncated AXIN1 isoform promotes hepatocellular carcinoma metastasis through SRSF9-mediated exon 9 skipping., PMID:38748384
A small molecule compound 759 inhibits the wnt/beta-catenin signaling pathway via increasing the Axin protein stability., PMID:38733492
Exploring the effects of Hippo signaling pathway on rumen epithelial proliferation., PMID:38730465
ARHGAP17 Inhibits Hepatocellular Carcinoma Progression by Inactivation of Wnt/β-Catenin Signaling Pathway., PMID:38724713
UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells., PMID:38715121
For research use only. Not for human or drug use.
