Catalog No.
YHA40701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr390-Val647
Predicted molecular weight
31.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15075
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Doublecortin-like and CAM kinase-like 1, DCAMKL1, KIAA0369, Doublecortin-like kinase 1, DCLK1, Doublecortin domain-containing protein 3A, Serine/threonine-protein kinase DCLK1, DCDC3A
Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems., PMID:40395933
Doublecortin-like kinase 1, regulated by STIP1 homology and U-box containing protein 1 or Sp1 transcription factor, affects the malignant behaviors and drug sensitivity in adriamycin-resistant breast cancer cells., PMID:40257489
A Novel D-peptide modulates DCLK1 Gelsolin interactions, reducing PDAC tumor growth., PMID:40162222
Evolving insights into pancreatic tumor initiation and progression through DCLK1-expressing tuft cells., PMID:40132546
Clinical significance of "S" isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody., PMID:40109216
DCLK1 in gastrointestinal cancer: A driver of tumor progression and a promising therapeutic target., PMID:40056091
Acute tuft cell ablation in mice induces malabsorption and alterations in secretory and immune cell lineages in the small intestine., PMID:40051209
DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma., PMID:39994636
ELF1's Role in Colorectal Cancer: Up-Regulating DCLK1 Expression to Propel Malignant Progression and Stemness Features., PMID:39973554
Inhibition of stemness and PD-L1 expression by Pien Tze Huang enhances T cell-mediated killing of colorectal cancer., PMID:39914691
Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer., PMID:39884575
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model., PMID:39786590
Doublecortin-like kinase 1 promotes stem cell-like properties through the Hippo-YAP pathway in prostate cancer., PMID:39781521
DCLK1 mediated cooperative acceleration of EMT by avian leukosis virus subgroup J and Marek's disease virus via the Wnt/β-catenin pathway promotes tumor metastasis., PMID:39445786
Intestinal Tuft Cells Are Enriched With Protocadherins., PMID:39360911
DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression., PMID:39288218
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model., PMID:39253444
Jiedu Xiaozheng Yin extract targets cancer stem cells by Wnt signaling pathway in colorectal cancer., PMID:39197803
Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue., PMID:39174821
Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression., PMID:38980538
A20 in hepatic stellate cells suppresses chronic hepatitis by inhibiting DCLK1-JNK pathway-dependent chemokines., PMID:38965999
From Inflammation to Oncogenesis: Tracing Serum DCLK1 and miRNA Signatures in Chronic Liver Diseases., PMID:38928187
DCLK1 Expression and its Functional Significance in Intrahepatic Cholangiocarcinoma and Bil-IN Stage., PMID:38821583
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway., PMID:38658095
DCLK1-Mediated Regulation of Invadopodia Dynamics and Matrix Metalloproteinase Trafficking Drives Invasive Progression in Head and Neck Squamous Cell Carcinoma., PMID:38645056
Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin., PMID:38613910
Ehf and Fezf2 regulate late medullary thymic epithelial cell and thymic tuft cell development., PMID:38420512
Equine enteroid-derived monolayers recapitulate key features of parasitic intestinal nematode infection., PMID:38414039
Discovery of a doublecortin-like kinase 1 inhibitor to prevent inflammatory responses in acute lung injury., PMID:38394920
Establishment of a chicken intestinal organoid culture system to assess deoxynivalenol-induced damage of the intestinal barrier function., PMID:38369477
A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation., PMID:38306414
DCLK1 is Overexpressed and Associated with Immune Cell Infiltration in Hepatocellular Carcinoma., PMID:38294590
Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline., PMID:38142716
Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation., PMID:38062554
Protein kinase D1 - A targetable mediator of pancreatic cancer development., PMID:38061566
Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice., PMID:38061015
The doublecortin-family kinase ZYG-8DCLK1 regulates motor activity to achieve proper force balance in C. elegans acentrosomal spindles., PMID:38045228
DCLK1 and its oncogenic functions: A promising therapeutic target for cancers., PMID:38007147
Epigenetic Landscape and Therapeutic Implication of Gene Isoforms of Doublecortin-Like Kinase 1 for Cancer Stem Cells., PMID:38003596
LGR5 Expression Predicting Poor Prognosis Is Negatively Correlated with WNT5A in Colon Cancer., PMID:37998393
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome., PMID:37996782
Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases., PMID:37883155
Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer., PMID:37862816
Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling network., PMID:37861336
Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer., PMID:37838282
Blockage of DCLK1 in cardiomyocytes suppresses myocardial inflammation and alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic mice., PMID:37778481
Molecular Mechanism of Mutational Disruption of DCLK1 Autoinhibition Provides a Rationale for Inhibitor Screening., PMID:37762326
Inferring circadian gene regulatory relationships from gene expression data with a hybrid framework., PMID:37752445
Proteomic investigation of neural stem cell to oligodendrocyte precursor cell differentiation reveals phosphorylation-dependent Dclk1 processing., PMID:37594553
Exosomes from metastatic colon cancer cells drive the proliferation and migration of primary colon cancer through increased expression of cancer stem cell markers CD133 and DCLK1., PMID:37487255
For research use only. Not for human or drug use.
