Catalog No.
YHA37101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr917-Asp1071
Predicted molecular weight
19.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14980
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Exportin-1, XPO1, Chromosome region maintenance 1 protein homolog, CRM1, Exp1
NEXUS: a phase I dose escalation study of selinexor plus nivolumab and ipilimumab in Asian patients with advanced/metastatic solid malignancies., PMID:40502306
RNA processing kinase inhibitors and epigenetic inhibitors in combination with oncology drugs or investigational agents in multi-cell type patient-derived tumor cell line spheroids., PMID:40470182
Selinexor in acute myeloid leukemia: therapeutic applications and current challenges., PMID:40463909
Targeting EP300 in diffuse large b-cell lymphoma: efficacy of A485 and synergistic effects with XPO1 inhibition., PMID:40437414
Prognostic impact of biomarkers in PMBCL: rationale for early integration of immune checkpoint inhibitors., PMID:40416849
Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1-dependent manner and reveal proviral roles of UPF1., PMID:40396490
Exploring the exportin-1 inhibitors for COVID-19 and anticancer treatment., PMID:40395159
Damnacanthal exerts anti-cancer effects in breast cancer cells via NAG-1 upregulation, CRM1 downregulation, and induction of autophagy., PMID:40381674
XPO1-Targeting Selective Inhibitors of Transcriptional Activation Suppress Graft-versus-Host Disease., PMID:40366915
Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era., PMID:40361510
Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition., PMID:40340946
[Clinical Significance of XPO1 High Expression in Diffuse Large B-Cell Lymphoma and Its Mechanism]., PMID:40326110
CRM1 mediates the nuclear export of YTHDF2., PMID:40315567
Modulation of anti-tumour immunity by XPO1 inhibitors., PMID:40291981
A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal., PMID:40238870
LncRNA HCG11 regulates selinexor sensitivity in multiple myeloma., PMID:40228640
KPT-330, A New Candidate Drug for Targeting NOTCH1 Overexpression in T-cell Acute Lymphoblastic Leukemia, An In Vitro and Silico Study., PMID:40216697
Targeting the undruggable MYC in cancer: the rationale of using XPO1 inhibitors., PMID:40214838
DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes., PMID:40204893
XPO1-dependency of DEK::NUP214 leukemia., PMID:40148556
CRM1 mediates ASC nuclear export and inflammasome activation., PMID:40139094
Selinexor's Immunomodulatory Impact in Advancing Multiple Myeloma Treatment., PMID:40136679
Investigation of dynamic regulation of TFEB nuclear shuttling by microfluidics and quantitative modelling., PMID:40089585
Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex., PMID:40068679
MYC networks associate with decreased CD8 T-cell presence in diffuse large B-cell lymphoma and may be addressed by the synergistic combination of AZD4573 and Selinexor - a preliminary analysis., PMID:40064656
Cracking melanoma's armor: Supramolecular dual-strike on XPO1 and β-catenin to overcome resistance., PMID:40044035
Efficacy and mechanism of the XPO1 inhibitor selinexor combined with decitabine in T-cell lymphoblastic lymphoma., PMID:40014082
Nuclear localization and transactivation of SYS-1/β-catenin is the result of serial gene duplications and subfunctionalizations., PMID:40010690
Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication., PMID:40007039
XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting., PMID:40001478
The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21., PMID:39952918
Association of non-gain-of-function alterations in exportin-1 with improved overall survival in colorectal cancer., PMID:39947513
4-Hydroxy-2-nonenal causes nuclear accumulation of p62 by inhibiting Xpo1 and promoting the proteolytic pathway in the nucleus., PMID:39899539
Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer., PMID:39888288
Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7-driven Small Cell Lung Cancer., PMID:39887933
CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor., PMID:39873970
Targeting CRM1 for Progeria Syndrome Therapy., PMID:39871520
Role of drug induced nuclear CTSL (nCTSL) in DNA damage response in cancer- therapeutic implications., PMID:39868276
Acquired mutations in patients with relapsed/refractory CLL who progressed in the ALPINE study., PMID:39853273
Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor., PMID:39806439
Anticancer and therapeutic efficacy of XPO1 inhibition in pancreatic ductal adenocarcinoma through DNA damage and modulation of miR-193b/KRAS/LAMC2/ERK/AKT signaling cascade., PMID:39778762
Mutations of Key Functional Residues in CRM1/XPO1 Differently Alter Its Intranuclear Localization and the Nuclear Export of Endogenous Cargos., PMID:39766285
Selinexor in combination with venetoclax and decitabine in patients with refractory myelodysplastic syndrome previously exposed to hypomethylating agents: three case reports., PMID:39749030
Prognostic and functional role of the nuclear export receptor 1 (XPO1) in gastrointestinal cancers: a potential novel target?, PMID:39729162
Violaceoid F induces nuclear translocation of FOXO3a by inhibiting CRM1 via a novel mechanism and suppresses HeLa cell growth., PMID:39727141
Integrative multi-omics analysis reveals a novel subtype of hepatocellular carcinoma with biological and clinical relevance., PMID:39712016
Prioritizing Parkinson's disease risk genes in genome-wide association loci., PMID:39711693
Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia., PMID:39708768
Targeting XPO1 for fighting relapsed/refractory diseases: The research progress of XPO1 inhibitors., PMID:39708554
Discovery, Validation and Mechanistic Study of XPO1 Inhibition in the Treatment of Triple-Negative Breast Cancer., PMID:39682167
For research use only. Not for human or drug use.
