Catalog No.
FHJ65711
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
FITC
Target
Spinal cord-derived growth factor, PDGFC receptor-binding form, SCDGF, PDGFC latent form, Fallotein, PDGF-C, VEGF-E, Platelet-derived growth factor C, PDGFC
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
Q9NRA1
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
SAA0450
PDGFRα inhibition reduces myofibroblast expansion in the fibrotic rim and enhances recovery after ischemic stroke., PMID:39808499
Targeting PDGF-CC as a promising therapeutic strategy to inhibit cholangiocarcinoma progression., PMID:39543636
Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse., PMID:36914817
Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation., PMID:35163520
Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier., PMID:33361796
Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction., PMID:32574573
Chemotherapeutic and antiangiogenic drugs beyond tumor progression in colon cancer: Evaluation of the effects of switched schedules and related pharmacodynamics., PMID:30953637
Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension., PMID:30827511
Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo., PMID:30052660
Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CChum mice., PMID:30021009
Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model., PMID:29850586
Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1., PMID:28977999
Homocysteine Facilitates Prominent Polygonal Angiogenetic Networks of a Choroidal Capillary Sprouting Model., PMID:28806447
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently., PMID:27788490
[Primary culture and characteristics of colorectal cancer-associated fibroblasts]., PMID:26702529
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration., PMID:26687981
Role of platelet-derived growth factor-CC in capillary rarefaction in renal fibrosis., PMID:26216283
Naturally occurring PDGF receptor inhibitors with potential anti-atherosclerotic properties., PMID:25737405
Genome-wide association study of antibody level response to NDV and IBV in Jinghai yellow chicken based on SLAF-seq technology., PMID:25588649
Accelerated wound closure in vitro by fibroblasts from a subgroup of cleft lip/palate patients: role of transforming growth factor-α., PMID:25360592
Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness., PMID:24126726
Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma., PMID:23929039
Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice., PMID:23856609
Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments., PMID:23338608
Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis., PMID:23141925
Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy., PMID:22238384
Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer., PMID:21224365
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets., PMID:20566880
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation., PMID:20231377
PDGF-CC induces tissue factor expression: role of PDGF receptor alpha/beta., PMID:19795151
Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy., PMID:19754219
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors., PMID:19366796
PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment., PMID:19352490
Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts., PMID:19118022
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment., PMID:19111878
Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy., PMID:19111874
PDGF receptors are activated in human epiretinal membranes., PMID:19032953
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke., PMID:18568034
PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis., PMID:18184860
Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy., PMID:18172073
PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines., PMID:18055825
PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells., PMID:17066417
PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid., PMID:16956736
Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma., PMID:16675559
Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells., PMID:16612331
Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation., PMID:15611105
Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts., PMID:15389578
PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases., PMID:12707385
v-erbA oncogene induces invasiveness and anchorage-independent growth in cultured glial cells by mechanisms involving platelet-derived growth factor., PMID:8838867
Radioimmunoassay of epidermal growth factor in human saliva and gastric juice., PMID:2040084
For research use only. Not for human or drug use.
