Catalog No.
YHA33501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu196-Thr445
Predicted molecular weight
30.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14896
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRF-6, Interferon regulatory factor 6, IRF6
IRF6 hits the sweet spot., PMID:40315828
A Large Multicenter Brazilian Case-Control Study Exploring Genetic Variations in Interferon Regulatory Factor 6 and the Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate., PMID:40244393
Major allelic variants in IRF6 and the association with Non-Syndromic orofacial Clefts: Insights from a Kerala-Based Case-Control study., PMID:40185345
Exploring the Role of IRF6 in Perinatal Arterial Ischemic Stroke: A Case of a Newborn with Craniofacial Malformations., PMID:40149423
Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation., PMID:40120584
Neural crest and periderm-specific requirements of Irf6 during neural tube and craniofacial development., PMID:40113028
Van der Woude syndrome and amniotic band sequence: A clue to a common genetic etiology? A case report., PMID:40084670
Transcriptomic and biometric parameters analysis in rainbow trout (Oncorhynchus mykiss) challenged with viral hemorrhagic septicemia virus (VHSV)., PMID:40021981
Cytoplasmic Shift of Interferon Regulatory Factors Co-Evolved With Jawed Vertebrate Innate Immunity., PMID:39977406
Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy., PMID:39867391
Uncovering selection pressures on the IRF gene family in bats' immune system., PMID:39776231
A Novel Genetic Variation Identified in Patients With Orofacial Clefts., PMID:39679673
Parental transmission effects of the IRF6 polymorphisms among Non-Syndromic Cleft Lip with or without cleft palate in Kerala case parent trios., PMID:39581118
High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene., PMID:39500877
Breast Cancer Stem Cells Upregulate IRF6 in Stromal Fibroblasts to Induce Stromagenesis., PMID:39273037
Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer's disease., PMID:39169269
Role of MTHFR, IRF6, PAX7 and TP63 SNPs in susceptibility to non-syndromic orofacial cleft, a candidate gene study in a Portuguese population., PMID:39049717
Programmed RNA editing with an evolved bacterial adenosine deaminase., PMID:38969862
A novel IRF6 gene mutation impacting the regulation of TGFβ2-AS1 in the TGFβ pathway: A mechanism in the development of Van der Woude syndrome., PMID:38903762
Sevoflurane inhibits lung cancer development by promoting FUS1 transcription via downregulating IRF6., PMID:38819072
Potentially functional genetic variants in interferon regulatory factor family genes are associated with colorectal cancer survival., PMID:38812445
A novel noncanonical function for IRF6 in the recycling of E-cadherin., PMID:38809584
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity., PMID:38604478
Review on the Role of IRF6 in the Pathogenesis of Non-syndromic Orofacial Clefts., PMID:38546517
Identification and validation of IRF6 related to ovarian cancer and biological function and prognostic value., PMID:38493179
A comprehensive consolidation of data on the relationship between IRF6 polymorphisms and non-syndromic cleft lip/palate susceptibility: From 79 case-control studies., PMID:38431084
Biophysical and functional characterization of N-terminal domain of Human Interferon Regulatory Factor 6., PMID:38429584
Genetic variant classification by predicted protein structure: A case study on IRF6., PMID:38370976
Identification of TACSTD2 as novel therapeutic targets for cisplatin-induced acute kidney injury by multi-omics data integration., PMID:38369676
[Correlation between methylation of interferon regulatory factor 6 gene promoter in renal tissues and overall survival of patients with Kidney renal clear cell carcinoma]., PMID:38311552
Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease., PMID:38260284
Development and validation of a combined hypoxia- and metabolism-related prognostic signature to predict clinical prognosis and immunotherapy responses in clear cell renal cell carcinoma., PMID:38023248
Association between IRF6, TP63, GREM1 Gene Polymorphisms and Non-Syndromic Orofacial Cleft Phenotypes in Vietnamese Population: A Case-Control and Family-Based Study., PMID:38002937
[Analysis of a Chinese pedigree affected with van der Woude syndrome due to variant of IRF6 gene]., PMID:37994134
Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease., PMID:37986771
DNA methylation effects on Van der Woude Syndrome phenotypic variability., PMID:37961322
An Integrative ATAC-Seq and RNA-Seq Analysis of the Endometrial Tissues of Meishan and Duroc Pigs., PMID:37834260
The IRF6 rs2013162 and MTHFR A1298C rs1801131 Gene Polymorphisms Related to non-Syndromic Cleft lip and Palate among Deutero-Malay in Indonesia., PMID:37533311
Identification and verification of a novel anoikis-related gene signature with prognostic significance in clear cell renal cell carcinoma., PMID:37402968
Rare variants found in multiplex families with orofacial clefts: Does expanding the phenotype make a difference?, PMID:37350193
Rare variants found in clinical gene panels illuminate the genetic and allelic architecture of orofacial clefting., PMID:37330696
A Variant in the IRF6 Promoter Associated with the Risk for Orofacial Clefting., PMID:37161310
Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis., PMID:37143676
A Complex Intrachromosomal Rearrangement Disrupting IRF6 in a Family with Popliteal Pterygium and Van der Woude Syndromes., PMID:37107607
Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model., PMID:37101388
PRMT1 Inhibition Selectively Targets BNC1-Dependent Proliferation, but not Migration in Squamous Cell Carcinoma., PMID:37034732
Genetic Risk Assessment of Nonsyndromic Cleft Lip with or without Cleft Palate by Linking Genetic Networks and Deep Learning Models., PMID:36901988
A Comprehensive Genetic Analysis of Slovenian Families with Multiple Cases of Orofacial Clefts Reveals Novel Variants in the Genes IRF6, GRHL3, and TBX22., PMID:36901693
Causal Variations at IRF6 Gene Identified in Van der Woude Syndrome Pedigrees., PMID:36866619
The IRF6 AP-2α binding site polymorphism relate to the severity of non-syndromic orofacial cleft of Indonesian patients., PMID:36847740
For research use only. Not for human or drug use.
