Catalog No.
YHA31301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys134
Predicted molecular weight
17.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14810
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Complexin-1, CPLX1, CPX I, Synaphin-2, Complexin I
The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo., PMID:40442258
Identification of Sequential Molecular Mechanisms and Key Biomarkers in Early Glaucoma by Integrated Bioinformatics Analysis., PMID:39495230
Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway., PMID:38834904
GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis., PMID:38671141
Associations of brain morphology with cortical proteins of cognitive resilience., PMID:38394722
Generation of iPSC lines (KAIMRCi003A, KAIMRCi003B) from a Saudi patient with Dravet syndrome carrying homozygous mutation in the CPLX1 gene and heterozygous mutation in SCN9A., PMID:38110787
Identification and verification of atrial fibrillation hub genes caused by primary mitral regurgitation., PMID:37960721
Identification and Validation of Synapse-related Hub Genes after Spinal Cord Injury by Bioinformatics Analysis., PMID:37170986
Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing., PMID:36797040
Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats., PMID:36675068
Proteomic analysis of spinal cord tissue in a rat model of cancer-induced bone pain., PMID:36545122
Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways., PMID:36420081
Epigenome-wide DNA methylation analysis of whole blood cells derived from patients with GAD and OCD in the Chinese Han population., PMID:36344488
Genome-Wide Placental Gene Methylations in Gestational Diabetes Mellitus, Fetal Growth and Metabolic Health Biomarkers in Cord Blood., PMID:35721735
PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model., PMID:34788174
Differential Retinal Protein Expression in Primary and Secondary Retinal Ganglion Cell Degeneration Identified by Integrated SWATH and Target-Based Proteomics., PMID:34445296
Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod., PMID:34305524
Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons., PMID:32609320
Convex combination sequence kernel association test for rare-variant studies., PMID:32100372
Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan., PMID:31875236
Long-term iron exposure causes widespread molecular alterations associated with memory impairment in mice., PMID:31136779
Contextual fear conditioning modulates the gene expression over time., PMID:30039834
MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission., PMID:29635364
Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age., PMID:29496544
Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese., PMID:29118371
Melatonin ameliorates anxiety and depression-like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease., PMID:28608594
Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID., PMID:28422131
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease., PMID:28108469
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding., PMID:26750116
Cortical PGC-1α-Dependent Transcripts Are Reduced in Postmortem Tissue From Patients With Schizophrenia., PMID:26683626
Increased complexin-1 and decreased miR-185 expression levels in Behçet's disease with and without neurological involvement., PMID:26577184
Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse., PMID:26019341
The schizophrenia risk gene product miR-137 alters presynaptic plasticity., PMID:26005852
Differential Gene Expression in Gonadotropin-Releasing Hormone Neurons of Male and Metestrous Female Mice., PMID:25925152
Functional roles of complexin in neurotransmitter release at ribbon synapses of mouse retinal bipolar neurons., PMID:25740533
Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia., PMID:25662103
Differences in human cortical gene expression match the temporal properties of large-scale functional networks., PMID:25546015
PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons., PMID:25339750
Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology., PMID:25112678
Unusual 4p16.3 deletions suggest an additional chromosome region for the Wolf-Hirschhorn syndrome-associated seizures disorder., PMID:24738919
Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse., PMID:22393426
Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics., PMID:22120873
Candidate pathway association study in cocaine dependence: the control of neurotransmitter release., PMID:21426264
Molecular evidence that cortical synaptic growth predominates during the first decade of life in humans., PMID:20888897
Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine., PMID:19346281
Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal., PMID:17652102
Early motor development is abnormal in complexin 1 knockout mice., PMID:17188502
No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population., PMID:16442780
Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits., PMID:16000319
For research use only. Not for human or drug use.
