Catalog No.
FHH18511
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
FITC
Target
Baboon M7 virus receptor, SLC1A5, Solute carrier family 1 member 5, ASCT2, RDR, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, ATB(0), Neutral amino acid transporter B(0), M7V1, RDRC
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
Q15758
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
SAA0181
ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5., PMID:39696988
HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration., PMID:39032683
ASCT2-Targeting Antibody-Drug Conjugate MEDI7247 in Adult Patients with Relapsed/Refractory Hematological Malignancies: A First-in-Human, Phase 1 Study., PMID:38683495
GLUT1 and ASCT2 expression and their prognostic value in colorectal carcinoma., PMID:38394402
ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus., PMID:37116342
Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer., PMID:34590499
The role of the glutamine transporter ASCT2 in antineoplastic therapy., PMID:33464409
Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions., PMID:33256735
Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation., PMID:31862915
ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma., PMID:31819178
Anti-tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS-mutated human colorectal cancer cells., PMID:31709772
Generation of a neutralizing antibody against RD114-pseudotyped viral vectors., PMID:31702531
Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes., PMID:31668020
Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma., PMID:31578313
Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome., PMID:30582284
An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models., PMID:30210919
Inhibition of SLC1A5 sensitizes colorectal cancer to cetuximab., PMID:29363109
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma., PMID:29348676
Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients., PMID:29337138
Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors., PMID:29020998
AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis., PMID:28823958
Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer., PMID:28804556
ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production., PMID:28553292
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis., PMID:28512249
Establishment of monoclonal antibodies against cell surface domains of ASCT2/SLC1A5 and their inhibition of glutamine-dependent tumor cell growth., PMID:27865832
ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis., PMID:27450723
Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta., PMID:26875564
Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo., PMID:26154387
Functional analyse of GLUT1 and GLUT12 in glucose uptake in goat mammary gland epithelial cells., PMID:23724114
Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain., PMID:19012749
Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core., PMID:17962467
Glutamine availability up-regulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter., PMID:15175006
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas., PMID:15094455
Biodistribution of the RD114/mammalian type D retrovirus receptor, RDR., PMID:15026986
Expression of neutral amino acid transporter ASCT2 in human prostate., PMID:12926082
Na(+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein., PMID:11502573
For research use only. Not for human or drug use.
