Catalog No.
YHA17001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu178-Asp381
Predicted molecular weight
25.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00622
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Insulin-like growth factor-binding protein 10, Protein GIG1, IGF-binding protein 10, CYR61, Cellular communication network factor 1, IBP-10, Cysteine-rich angiogenic inducer 61, GIG1, Protein CYR61, CCN1, IGFBP-10, IGFBP10, CCN family member 1
CYR61 as a Potential Biomarker and Target in Cancer Prognosis and Therapies., PMID:40497940
Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy., PMID:40450269
Ligand-Receptor Interactions Between Squamous and Endothelial Cells Induce Head and Neck Squamous Cell Carcinoma., PMID:40418639
The influence of CCN family proteins on ovarian physiology and pathology., PMID:40359309
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways., PMID:40339921
The Role of Hippo Signaling in Brain Arteriovenous Malformations: Molecular Insights into Post-Embolization Remodeling., PMID:40332417
Wogonin potentiates the irradiation effect on hepatocellular carcinoma by activating the Hippo-Yes-associated protein/transcriptional co-activator with PDZ-binding motif pathway., PMID:40318272
CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer., PMID:40287974
The multifunctional protein CCN1/CYR61: Bridging physiology and disease., PMID:40286773
circ_0002970 promotes fibroblast-like synoviocytes invasion and the inflammatory response through Hippo/YAP signaling to induce CTGF/CCN1 expression in rheumatoid arthritis., PMID:40281642
Piezo1-Mediated Calcium Flux Transfers Mechanosignal to Yes-Associated Protein to Stimulate Matrix Production in Keloid., PMID:40254148
CCN1 is a therapeutic target upregulated in EML4-ALK mutant lung adenocarcinoma reversibly resistant to alectinib., PMID:40234387
Cysteine-Rich Protein 61 (CCN1) Deficiency Alleviated Cardiac Remodeling in 5/6 Nephrectomized Mice by Suppressing the MAPK Signaling Pathway., PMID:40225592
Correction to "Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling"., PMID:40192665
Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway., PMID:40165038
Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis., PMID:40056245
C-terminal binding protein-2 triggers CYR61-induced metastatic dissemination of osteosarcoma in a non-hypoxic microenvironment., PMID:40038783
WISP1 promotes the progression of rheumatoid arthritis through NLRP3 inflammasome activation., PMID:39938456
CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer's disease model mice., PMID:39929589
CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma., PMID:39806221
WISP1 inhibition of YAP phosphorylation drives breast cancer growth and chemoresistance via TEAD4 activation., PMID:39774151
Paeoniflorin sensitizes imatinib mesylate-resistant chronic myeloid leukemia cells via the inhibition of Cyr61 production., PMID:39773616
[The Correlation of Serum CMTM6 and CCN1 Expression with Clinical Efficacy and Prognosis of Patients with Acute Leukemia]., PMID:39743247
A Role for the Hippo/YAP1 Pathway in the Regulation of In Vitro Vasculogenic Mimicry in Glioblastoma Cells., PMID:39718433
CCN1 Promotes Mesenchymal Phenotype Transition Through Activating NF-κB Signaling Pathway Regulated by S100A8 in Glioma Stem Cells., PMID:39659236
Integrative bioinformatics analysis reveals novel insights into osteoarthritis pathogenesis and diagnostic biomarkers., PMID:39639239
Meta-analysis of proteomics data from osteoblasts, bone, and blood: Insights into druggable targets, active factors, and potential biomarkers for bone biomaterial design., PMID:39620099
CYR61 as a Potential Apoptosis Biomarker in Osteoarthritis with Comorbidities., PMID:39616508
Integrative transcriptome analysis reveals Serpine2 promotes glomerular mesangial cell proliferation and extracellular matrix accumulation via activating ERK1/2 signalling pathway in diabetic nephropathy., PMID:39557806
Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma., PMID:39524140
Combined analyses of mRNA and miRNA transcriptome reveal the molecular mechanisms of theca cells physiological differences in geese follicular selection stage., PMID:39510003
Restoring social deficits in IRSp53-deleted mice: chemogenetic inhibition of ventral dentate gyrus Emx1-expressing cells., PMID:39375329
CYR61/CCN1: A novel mediator of redox response in corneal stromal cells of keratoconus., PMID:39277098
The Crosstalk Analysis between mPSCs and Panc1 Cells Identifies CCN1 as a Positive Regulator of Gemcitabine Sensitivity in Pancreatic Cancer Cells., PMID:39273316
Research advances on silence information regulator 6 as a potential therapeutic target for bone regeneration and repair., PMID:39183069
Identification of molecular targets and small drug candidates for Huntington's disease via bioinformatics and a network-based screening approach., PMID:39153206
IGF2BP1-Mediated Regulation of CCN1 Expression by Specific Binding to G-Quadruplex Structure in Its 3'UTR., PMID:39133064
Hypoxia-initiated Cysteine-rich protein 61 secretion promotes chemoresistance of acute B lymphoblastic leukemia cells., PMID:39113880
Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction., PMID:39098433
Cysteine-rich 61 inhibition attenuates hepatic insulin resistance and improves lipid metabolism in high-fat diet fed mice and HepG2 cells., PMID:39082187
A new insight into the pathway behind spontaneous recurrent pregnancy loss: decreased CYR61 gene expression., PMID:39045957
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation., PMID:38981023
Nanomechanics of CCN1-Mediated Staphylococcus aureus Phagocytosis., PMID:38959438
CYR61 is Involved in Neonatal Hypoxic-ischemic Brain Damage Via Modulating Astrocyte-mediated Neuroinflammation., PMID:38908506
CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway., PMID:38904029
Transcriptional regulation of CYR61 and CTGF by LM98: a synthetic YAP-TEAD inhibitor that targets in-vitro vasculogenic mimicry in glioblastoma cells., PMID:38900643
Human trophoblast invasion and migration are mediated by the YAP1-CCN1 pathway: defective signaling in trophoblasts during early-onset severe preeclampsia†., PMID:38874283
Investigating the Effects of AL049796.1 Silencing in Inhibiting High Glucose-Induced Colorectal Cancer Progression., PMID:38853745
Multi-omics Analysis Revealed that the CCN Family Regulates Cell Crosstalk, Extracellular Matrix, and Immune Escape, Leading to a Poor Prognosis of Glioma., PMID:38837011
The role of yes activated protein (YAP) in melanoma metastasis., PMID:38770136
For research use only. Not for human or drug use.
