Catalog No.
YHA13601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser300-Ala541
Predicted molecular weight
30.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00482
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Liver receptor homolog 1, hB1F, NR5A2, Alpha-1-fetoprotein transcription factor, CYP7A promoter-binding factor, B1-binding factor, FTF, Nuclear receptor subfamily 5 group A member 2, LRH-1, B1F, CPF, Hepatocytic transcription factor
Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma., PMID:40269773
The self-renewal function of Oct-4 can be replaced by the EWS-Oct-4 fusion protein in embryonic stem cells., PMID:40251420
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway., PMID:40194607
CYP3A Genotype Is Associated With Variability in the Exposure and Clearance of the Novel Oncogenic Transcription Inhibitor Lurbinectedin., PMID:40146606
Transcriptome and chromatin accessibility landscape of ovarian development at different egg-laying stages in taihe black-bone silky fowls., PMID:39922133
Role of NR5A2 in regulating sex differentiation, steroidogenesis, and gonadal development in Chlamys farreri., PMID:39914682
Genome-Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours., PMID:39814695
LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype., PMID:39702941
Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts., PMID:39562549
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression., PMID:39438459
Enhancing human islet xenotransplant survival and function in diabetic immunocompetent mice through LRH-1/NR5A2 pharmacological activation., PMID:39399499
Nr5a2 is dispensable for zygotic genome activation but essential for morula development., PMID:39361745
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation., PMID:39358607
NR0B2 Is a Key Factor for Gastric Diseases: A GEO Database Analysis Combined with Drug-Target Mendelian Randomization., PMID:39336801
p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator., PMID:38994678
A single-cell atlas of chromatin accessibility in mouse organogenesis., PMID:38977846
Pioneer Transcription Factors: The First Domino in Zygotic Genome Activation., PMID:38927123
Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle., PMID:38804232
The transcription factor OCT6 promotes the dissolution of the naïve pluripotent state by repressing Nanog and activating a formative state gene regulatory network., PMID:38710730
Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2., PMID:38685137
Liver receptor homolog-1: structures, related diseases, and drug discovery., PMID:38632319
Identification of Lower Grade Glioma Antigens Based on Ferroptosis Status for mRNA Vaccine Development., PMID:38623558
Mitotic bookmarking by transcription factors: be aware of redundancy., PMID:38503673
NR5A1 and NR5A2 regulate follicle development in chicken (Gallus gallus) by altering proliferation, apoptosis, and steroid hormone synthesis of granulosa cells., PMID:38492249
Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition., PMID:38409506
Nr5a2 ensures inner cell mass formation in mouse blastocyst., PMID:38386558
NR5A2 promotes malignancy progression and mediates the effect of cisplatin in cutaneous squamous cell carcinoma., PMID:38358044
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos., PMID:38243114
Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells., PMID:38196033
Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos., PMID:38096290
Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death., PMID:38039134
Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1., PMID:38031019
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity., PMID:38012687
LRH-1 agonist DLPC through STAT6 promotes macrophage polarization and prevents parenteral nutrition-associated cholestasis in mice., PMID:37976384
NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos., PMID:37935903
Transcriptional profiling of Kiss1 neurons from arcuate and rostral periventricular hypothalamic regions in female mice., PMID:37934722
Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation., PMID:37796967
A workflow to study mechanistic indicators for driver gene prediction with Moonlight., PMID:37551622
Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve., PMID:37494420
NR5A2/HSD3B1 pathway promotes cellular resistance to second-generation antiandrogen darolutamide., PMID:37478518
Single-Cell RNA-Seq Identifies Pathways and Genes Contributing to the Hyperandrogenemia Associated with Polycystic Ovary Syndrome., PMID:37445796
NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation., PMID:37353485
Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease., PMID:37348559
Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators., PMID:37328104
Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence., PMID:37285077
Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma., PMID:37204028
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1., PMID:37074920
LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis., PMID:37057309
NR5A2 as a potential target for exercise to improve metabolic syndrome., PMID:37053002
LRH-1 induces hepatoprotective nonessential amino acids in response to acute liver injury., PMID:37009899
For research use only. Not for human or drug use.
