Catalog No.
YHA12701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys1856-Val2045
Predicted molecular weight
22.56 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00468
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AGRN, C22, Agrin, C90, AGRIN
Note
For research use only.
Agrin promotes the proliferation, invasion and migration of rectal cancer cells via the WNT signaling pathway to contribute to rectal cancer progression., PMID:32862766
A Comprehensive Analysis of Unique and Recurrent Copy Number Variations in Alzheimer's Disease and its Related Disorders., PMID:33256577
Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors., PMID:33260559
Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of Congenital Myasthenic Syndrome., PMID:33390901
Molecular mechanisms of osteogenesis and antibacterial activity of Cu-bearing Ti alloy in a bone defect model with infection in vivo., PMID:33437640
Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway., PMID:33713277
Myasthenia gravis genome-wide association study implicates AGRN as a risk locus., PMID:34400559
Novel LG1 Mutations in Agrin Causing Congenital Myasthenia Syndrome., PMID:34433720
Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker., PMID:34785582
Mutational screening of AGRN, SLC39A5, SCO2, P4HA2, BSG, ZNF644, and CPSF1 in a Chinese cohort of 103 patients with nonsyndromic high myopia., PMID:35002215
SPINK5 is a Prognostic Biomarker Associated With the Progression and Prognosis of Laryngeal Squamous Cell Carcinoma Identified by Weighted Gene Co-Expression Network Analysis., PMID:35140453
CRABP1-CaMKII-Agrn regulates the maintenance of neuromuscular junction in spinal motor neuron., PMID:35217789
Methylated DNA markers for plasma detection of ovarian cancer: Discovery, validation, and clinical feasibility., PMID:35370009
Clinicopathological-genetic features of congenital myasthenic syndrome from a Chinese neuromuscular centre., PMID:35670010
A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing., PMID:35765657
Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons., PMID:35948834
Congenital Myasthenic Syndromes in Turkey: Clinical and Molecular Characterization of 16 Cases With Three Novel Mutations., PMID:36099689
Unfolding of Novel Independent Missense Mutations in VAMP2 and AGRN and Their Collective Role in Global Developmental Delay: A Case Report., PMID:36176870
A link between agrin signalling and Cav3.2 at the neuromuscular junction in spinal muscular atrophy., PMID:36347955
Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity., PMID:36384140
Diagnostic yield of a practical electrodiagnostic protocol discriminating between different congenital myasthenic syndromes., PMID:36522822
Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration., PMID:36609795
Matrine restrains the development of colorectal cancer through regulating the AGRN/Wnt/β-catenin pathway., PMID:36620879
Urinary protein biomarkers based on LC-MS/MS analysis to discriminate vascular dementia from Alzheimer's disease in Han Chinese population., PMID:36761180
Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes-A Comprehensive Review., PMID:36835142
Neural Isoforms of Agrin Are Generated by Reduced PTBP1-RNA Interaction Network Spanning the Neuron-Specific Splicing Regions in AGRN., PMID:37108583
AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target., PMID:37321467
Agrin is a novel oncogenic protein in thyroid cancer., PMID:37818129
Bioinformatics-based analysis of the roles of basement membrane-related gene AGRN in systemic lupus erythematosus and pan-cancer development., PMID:37841281
The YAP1/TAZ-TEAD transcriptional network regulates gene expression at neuromuscular junctions in skeletal muscle fibers., PMID:38048326
Mimicked Spinal Cord Fibers Trigger Axonal Regeneration and Remyelination after Injury., PMID:38078771
Identification and validation of plasma AGRN as a novel diagnostic biomarker of hepatitis B Virus-related chronic hepatitis and liver fibrosis/cirrhosis., PMID:38197199
Transcriptome Profiling Identifies Differentially Expressed Genes in Skeletal Muscle Development in Native Chinese Ducks., PMID:38254942
Mild hypothermia reduces lipopolysaccharide-induced microglial activation via down-regulation of Tent5c., PMID:38484570
Suppression of AGRN enhances CD8+ T cell recruitment and inhibits breast cancer progression., PMID:38568853
Proteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model., PMID:38580754
Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis., PMID:38696726
Identification of a basement membrane-related gene signature for predicting prognosis, immune infiltration, and drug sensitivity in colorectal cancer., PMID:39011483
Copy number variation and clinical response to chemotherapy and bevacizumab in the Czech metastatic colorectal cancer patients., PMID:39174331
Local protein synthesis at neuromuscular synapses is required for motor functions., PMID:39178112
Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients., PMID:39334929
Targeted Therapy of Osteoarthritis via Intra-Articular Delivery of Lipid-Nanoparticle-Encapsulated Recombinant Human FGF18 mRNA., PMID:39363784
Acute high-intensity muscle contraction moderates AChR gene expression independent of rapamycin-sensitive mTORC1 pathway in rat skeletal muscle., PMID:39501426
Analysing glycolysis-related genes reveals the prognostic and diagnostic relevance of IER3 and AGRN in colorectal cancer., PMID:40048143
Cellular SLC35B4 promotes internalization during influenza A virus entry., PMID:40130891
Identifying novel AGRN variants in congenital myasthenic syndrome: insights from three Iranian families., PMID:40157165
Agrin-deficient osteocytes disrupt bone tissue homeostasis in male mice., PMID:40158584
A model of basement membrane-related regulators for prediction of prognoses in esophageal cancer and verification in vitro., PMID:40234833
Cerebrospinal fluid protein biomarkers are associated with response to multiagent intraventricular chemotherapy in patients with CNS lymphoma., PMID:40321620
For research use only. Not for human or drug use.
