Catalog No.
YHA11701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe172-Asn403
Predicted molecular weight
28.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00443
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphoinositide 3-kinase-C2-alpha, PIK3C2A, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PtdIns-3-kinase C2 subunit alpha, PI3K-C2-alpha
Transcriptome analysis reveals the genetic basis underlying the formation and seasonal changes of nuptial pads in Rana chensinensis., PMID:39736519
Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture., PMID:39454693
Post-stroke hippocampal neurogenesis is impaired by microvascular dysfunction and PI3K signaling in cerebral amyloid angiopathy., PMID:39392753
The role of miR-133a in silibinin-mediated inhibition of the PI3K/AKT/mTOR pathway in MCF-7 breast carcinoma cells., PMID:38504785
PI3KC2α inhibition is antithrombotic in blood from hypercholesterolemic mice., PMID:37827379
Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases., PMID:37798313
Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells., PMID:37315586
PIK3C2A is a prognostic biomarker that is linked to immune infiltrates in kidney renal clear cell carcinoma., PMID:37063922
Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome., PMID:36830671
C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection., PMID:36132983
Expanding the phenotype of PIK3C2A related syndrome: Report of two siblings with novel features and genotype., PMID:35770347
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer., PMID:35623884
The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery., PMID:35449600
Bioinformatics and network-based approaches for determining pathways, signature molecules, and drug substances connected to genetic basis of schizophrenia etiology., PMID:35339428
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation., PMID:34882480
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases., PMID:34537014
Anti-apoptotic Effect of MiR-223-3p Suppressing PIK3C2A in Cardiomyocytes from Myocardial Infarction Rat Through Regulating PI3K/Akt Signaling Pathway., PMID:33999393
Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide., PMID:33988680
LncRNA KCNQ1OT1 attenuates osteoarthritic chondrocyte dysfunction via the miR-218-5p/PIK3C2A axis., PMID:33783609
Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells., PMID:33664344
Luteolin inhibits proliferation, triggers apoptosis and modulates Akt/mTOR and MAP kinase pathways in HeLa cells., PMID:33574931
Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization., PMID:33380489
Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study., PMID:33317189
Primary cilium-dependent autophagy drafts PIK3C2A to generate PtdIns3P in response to shear stress., PMID:32102612
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress., PMID:31941925
The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium., PMID:31715259
Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction., PMID:31034465
Low expression of PIK3C2A gene: A potential biomarker to predict the risk of acute myocardial infarction., PMID:30946353
Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking., PMID:30884740
Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma., PMID:30697495
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data., PMID:30641220
PI3Kinases in Diabetes Mellitus and Its Related Complications., PMID:30567315
Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice., PMID:30476019
MicroRNA-31 inhibits osteosarcoma cell proliferation, migration and invasion by targeting PIK3C2A., PMID:30468462
The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition., PMID:30421419
The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells., PMID:30374841
Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2α., PMID:30293811
Identification of novel diabetes impaired miRNA-transcription factor co-regulatory networks in bone marrow-derived Lin-/VEGF-R2+ endothelial progenitor cells., PMID:29995913
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2α To Activate Productive Viral Replication., PMID:29950425
Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance., PMID:29764505
Phase I dose-escalation study of copanlisib in combination with gemcitabine or cisplatin plus gemcitabine in patients with advanced cancer., PMID:29348486
Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival., PMID:29087515
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function., PMID:29017056
MicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis., PMID:28919376
PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles., PMID:28910396
Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder., PMID:28195573
KRAS genetic variant as a prognostic factor for recurrence in resectable non-small cell lung cancer., PMID:28150169
A four-gene signature predicts survival in clear-cell renal-cell carcinoma., PMID:27779101
High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions., PMID:27412598
PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells., PMID:27270320
For research use only. Not for human or drug use.
