Catalog No.
YHA11401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn2-Ile343
Predicted molecular weight
40.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00425
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Insulin-like growth factor 2 mRNA-binding protein 3, VICKZ3, IGF2BP3, IMP3, KH domain-containing protein overexpressed in cancer, IMP-3, VICKZ family member 3, IGF-II mRNA-binding protein 3, KOC1, hKOC, IGF2 mRNA-binding protein 3
Identify the co-expressed genes of hypertensive nephropathy and diabetic nephropathy., PMID:40461634
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer., PMID:40448344
hsa_circ_0007376 Promotes Gastric Cancer Proliferation and Malignant Metastasis by Enhancing the Stability of IGF2BP3., PMID:40418151
GPCPD1 is regulated by METTL3/IGF2BP3 dependent m6A modification to affect pig muscle fiber type conversion., PMID:40404071
IGF2BP3-regulated circPLEKHH2 promotes autophagy via AKT/mTOR signaling pathway to suppress lung adenocarcinoma progression., PMID:40398791
METTL14 promotes TBK1 mRNA stability through IGF2BP3-recognized m6A modification and enhances mitophagy in BMSCs., PMID:40381973
Identification and validation of a 9-RBPs-related gene signature associated with prognosis and immune infiltration in bladder cancer based on bioinformatics analysis and machine learning., PMID:40376515
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression., PMID:40370540
IGF2BP3-mediated m6A modification of RASGRF1 promoting joint injury in rheumatoid arthritis., PMID:40355406
LINC01614 enhances neural invasion and gastric cancer progression by stabilizing VCAM1 and activating the AKT/mTOR pathway., PMID:40349810
m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability., PMID:40328743
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression., PMID:40301554
High‑dose sodium propionate contributes to tumor immune escape through the IGF2BP3/PD‑L1 axis in colorectal cancer., PMID:40291473
Aberrant overexpression of m6A writer and reader genes in pediatric B-Cell Acute Lymphoblastic Leukemia (B-ALL)., PMID:40288000
Genome-wide association studies of the fatty acid composition of Korean native chicken breast meat., PMID:40264524
Hepatitis B Virus Promotes Angiogenesis in Hepatocellular Carcinoma by Increasing m6A Modification of VEGFA mRNA via IGF2BP3., PMID:40260505
The m6A hypermethylation-induced PIR overexpression regulates H3K4me3 and promotes tumorigenesis of uveal melanoma., PMID:40252822
The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer., PMID:40247055
IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming., PMID:40240362
FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas., PMID:40234389
METTL3/IGF2BP3 mediates ORC6 via N6-methyladenosine modification to promote the progression of pancreatic ductal adenocarcinoma., PMID:40185346
IGF2BP3 As a Prognostic Biomarker and Regulator of Metastasis in Merkel Cell Carcinoma., PMID:40162116
RNA Binding Protein IGF2BP3 Rehabilitates Glycolysis of Vascular Endothelial Cells to Protect the ox-LDL-induced Cellular Injury via Stabilizing LDHA mRNA., PMID:40159306
HaloPROTAC3 treatment activates the unfolded protein response of the endoplasmic reticulum in nonengineered mammalian cell lines., PMID:40105918
The N6-methyladenosine reader IGF2BP3 promotes bladder cancer progression through enhancing HSP90AB1 expression., PMID:40105114
IGF2BP3 promotes the proliferation and cisplatin resistance of bladder cancer by enhancing the mRNA stability of CDK6 in an m6A dependent manner., PMID:40083693
The m6A reader IGF2BP3 promotes HCC progression by enhancing MCM10 stability., PMID:40065065
Impact of IMP3 Expression on Chemotherapy Response and Prognosis in Triple-Negative Breast Cancer: A Retrospective Cohort Study., PMID:40058835
Histone acetylation activated-IGF2BP3 regulates cyclin D1 mRNA stability to drive cell cycle transition and tumor progression of hepatocellular carcinoma., PMID:40037458
IGF2BP3 prefers to regulate alternative splicing of genes associated with the progression of gastric cancer in AGS cells., PMID:39998701
IGF2BP3 facilitates the osteogenic differentiation of bone marrow mesenchyml stem cells via upregulating KLK4., PMID:39988894
Structural basis for the RNA binding properties of mouse IGF2BP3., PMID:39986276
RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer., PMID:39962467
Identification of IGF2BPs-related mRNA signature for predicting the overall survival of lung adenocarcinoma., PMID:39956818
CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway., PMID:39931528
METTL3-mediated NFAT5 Upregulation Promotes Cervical Cancer Progression Through Enhancing the Mitochondrial Function by Transcriptional Regulation of PRDX1., PMID:39925026
Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner., PMID:39910429
Curcumol promotes immune cell invasion and inhibits angiogenesis in colon cancer by decreasing IGF2BP3 expression., PMID:39899937
IGF2BP3 is upregulated in endometrial cancer and tightly regulates the growth of drug-resistant endometrial cancer cells via HMGA1., PMID:39878052
Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis., PMID:39856555
Methyltransferase-like 3 mediates m6A modification of heme oxygenase 1 mRNA to induce ferroptosis of renal tubular epithelial cells in acute kidney injury., PMID:39837470
IGF2BP3 Triggers STAT3 Pathway by Stabilizing SRC RNA in an m6A-Dependent Manner to Promote Lymphatic Metastasis in LUAD., PMID:39805702
Profiling of snoRNAs in Exosomes Secreted from Cells Infected with Influenza A Virus., PMID:39795871
Enterolactone combined with m6A Reader IGF2BP3 inhibits malignant angiogenesis and disease progression in ovarian cancer., PMID:39765033
LIN28A-dependent lncRNA NEAT1 aggravates sepsis-induced acute respiratory distress syndrome through destabilizing ACE2 mRNA by RNA methylation., PMID:39762837
Epigenetic modification mediated by PHF20/METTL14/HOXA13 signaling axis modulates osteogenic differentiation of mesenchymal stem cells., PMID:39757292
IGF2BP3 curbed by miR-15c-3p restores disrupted lipid storage and progesterone secretion in chicken granulosa cells under oxidative stress through AKT-Raf1-ERK1/2 signaling pathway., PMID:39754922
WTAP/IGF2BP3 Mediated m6A Modification of SOD2 mRNA Aggravates the Tumourigenesis of Colorectal Cancer., PMID:39749662
Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation., PMID:39747079
Construction and clinical application of a risk model based on N6-methyladenosine regulators for colorectal cancer., PMID:39717046
For research use only. Not for human or drug use.
