Catalog No.
YHN54601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys80-Asn295
Predicted molecular weight
25.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HCC0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit, 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, MCCB, MCCC2, 3-methylcrotonyl-CoA carboxylase 2, MCCase subunit beta
SIRT4 Controls Acetyl-CoA Synthesis to Promote Stemness and Invasiveness of Hepatocellular Carcinoma through Deacetylating MCCC2., PMID:40384857
Expression of MCCC2 in glioma cells and preliminary verification of poor prognosis., PMID:40035348
Genome-wide statistical evidence elucidates candidate factors of life expectancy in dogs., PMID:39580055
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis., PMID:38783226
Transcriptomics and UHPLC-QQQ-MS analyses reveal the dysregulation of branched chain amino acids metabolism in renal fibrotic rats., PMID:38723558
Pathogenic/likely pathogenic mutations identified in Vietnamese children diagnosed with autism spectrum disorder using high-resolution SNP genotyping platform., PMID:38287090
Screening of 1.17 million newborns for inborn errors of metabolism using tandem mass spectrometry in Shanghai, China: A 19-year report., PMID:38061323
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer., PMID:37828426
Exploring the molecular and clinical spectrum of COVID-19-related acute necrotizing encephalopathy in three pediatric cases., PMID:37491516
[Analysis of MCCC2 gene variant in a pedigree affected with 3-methylcrotonyl coenzyme A carboxylase deficiency]., PMID:33423264
MCCC2 promotes HCC development by supporting leucine oncogenic function., PMID:33407468
Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study., PMID:33317189
High-throughput screening reveals novel mutations in spinal muscular atrophy patients., PMID:33148303
Methylcrotonoyl-CoA Carboxylase 2 Promotes Proliferation, Migration and Invasion and Inhibits Apoptosis of Prostate Cancer Cells Through Regulating GLUD1-P38 MAPK Signaling Pathway., PMID:32801758
[Genetic analysis of newborns with abnormal metabolism of 3-hydroxyisovalerylcarnitine]., PMID:31901042
3-Methylcrotonyl-CoA carboxylase deficiency: Mutational spectrum derived from comprehensive newborn screening., PMID:27601257
[A novel compound heterozygous mutation causing 3-methylcrotonyl-CoA carboxylase deficiency]., PMID:27577216
A 3-methylcrotonyl-CoA carboxylase deficient human skin fibroblast transcriptome reveals underlying mitochondrial dysfunction and oxidative stress., PMID:27417235
Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations., PMID:26850065
Biotin-dependent functions in adiposity: a study of monozygotic twin pairs., PMID:26601567
Identification of eight novel mutations and transcript analysis of two splicing mutations in Chinese newborns with MCC deficiency., PMID:25382614
[Follow up and gene mutation analysis in cases suspected as 3-methylcrotonyl-coenzyme A carboxylase deficiency by neonatal screening]., PMID:25190158
Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines., PMID:21829708
Profiling protein markers associated with lymph node metastasis in prostate cancer by DIGE-based proteomics analysis., PMID:19894759
Isolation and identification of 3-methylcrotonyl coenzyme A carboxylase cDNAs and pyruvate carboxylase, and their expression in red seabream (Pagrus major) organs., PMID:15690100
For research use only. Not for human or drug use.
