Catalog No.
YHG63801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala360-Gly485
Predicted molecular weight
16.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13724
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GCS1, MOGS, Processing A-glucosidase I, Mannosyl-oligosaccharide glucosidase
Recruitment of USP10 by GCS1 to deubiquitinate GRP78 promotes the progression of colorectal cancer via alleviating endoplasmic reticulum stress., PMID:39267084
Proteome and Glycoproteome Analyses Reveal Regulation of Protein Glycosylation Site-Specific Occupancy and Lysosomal Hydrolase Maturation by N-Glycan-Dependent ER-Quality Control., PMID:39235835
Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses., PMID:39220688
Early onset epileptic and developmental encephalopathy and MOGS variants: a new diagnosis in the whole exome sequencing (WES) ERA : Report of a new patient and review of the literature., PMID:38498292
Acremonium sp. diglycosidase-aid chemical diversification: valorization of industry by-products., PMID:38430417
Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity., PMID:36762932
Identification of Endoplasmic Reticulum α-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design., PMID:35476408
Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells., PMID:35227758
Serum N-glycomics of a novel CDG-IIb patient reveals aberrant IgG glycosylation., PMID:35137040
N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity., PMID:34870992
Structure of a bacterial α-1,2-glucosidase defines mechanisms of hydrolysis and substrate specificity in GH65 family hydrolases., PMID:34728215
Congenital disorders of glycosylation type IIb with MOGS mutations cause early infantile epileptic encephalopathy, dysmorphic features, and hepatic dysfunction., PMID:33261925
The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication., PMID:32985653
HILIC-UPLC-MS for high throughput and isomeric N-glycan separation and characterization in Congenital Disorders Glycosylation and human diseases., PMID:32915358
α-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19., PMID:32510142
Mannosyl-oligosaccharide glucosidase - congenital disorder of glycosylation: A patient with novel variants., PMID:32246563
Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections., PMID:32227946
Identification and characterization of novel mutations in MOGS in a Chinese patient with infantile spams., PMID:31925597
Anti-melanogenic activity of salacinol by inhibition of tyrosinase oligosaccharide processing., PMID:31883005
The flavonoid degrading fungus Acremonium sp. DSM 24697 produces two diglycosidases with different specificities., PMID:31705182
Optimization of an artificial cellulase cocktail for high-solids enzymatic hydrolysis of cellulosic materials with different pretreatment methods., PMID:31669875
Lack of selective resistance of influenza A virus in presence of host-targeted antiviral, UV-4B., PMID:31097731
Characterizing the selectivity of ER α-glucosidase inhibitors., PMID:30976784
Compound heterozygous variants in MOGS inducing congenital disorders of glycosylation (CDG) IIb., PMID:30587846
Abrogation of glucosidase I-mediated glycoprotein deglucosylation results in a sick phenotype in fission yeasts: Model for the human MOGS-CDG disorder., PMID:30389790
In silico analysis of different signal peptides to discover a panel of appropriate signal peptides for secretory production of Interferon-beta 1b in Escherichia coli., PMID:30378597
Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine., PMID:30135205
Lysosomal Targeting Enhancement by Conjugation of Glycopeptides Containing Mannose-6-phosphate Glycans Derived from Glyco-engineered Yeast., PMID:29880804
p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression., PMID:29465311
Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo., PMID:29253498
Characteristic dysmorphic features in congenital disorders of glycosylation type IIb., PMID:29235540
Marginal stability drives irreversible unfolding of large multi-domain family 3 glycosylhydrolases from thermo-tolerant yeast., PMID:29141194
Trichoderma virens β-glucosidase I (BGLI) gene; expression in Saccharomyces cerevisiae including docking and molecular dynamics studies., PMID:28637443
Quality control of glycoprotein folding and ERAD: the role of N-glycan handling, EDEM1 and OS-9., PMID:27803995
Composition and Bioactivity of Lipophilic Metabolites from Needles and Twigs of Korean and Siberian Pines (Pinus koraiensis Siebold & Zucc. and Pinus sibirica Du Tour)., PMID:27449469
Experimental Evolution of Trichoderma citrinoviride for Faster Deconstruction of Cellulose., PMID:26820897
Mitotic Intragenic Recombination: A Mechanism of Survival for Several Congenital Disorders of Glycosylation., PMID:26805780
Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy., PMID:26794905
Utilization of recombinant Trichoderma reesei expressing Aspergillus aculeatus β-glucosidase I (JN11) for a more economical production of ethanol from lignocellulosic biomass., PMID:26026380
Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8., PMID:25712767
The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins., PMID:25583996
Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections., PMID:25318123
Glycosylation, hypogammaglobulinemia, and resistance to viral infections., PMID:24716661
OsMOGS is required for N-glycan formation and auxin-mediated root development in rice (Oryza sativa L.)., PMID:24597623
N-glycomic profiling of a glucosidase II mutant of Dictyostelium discoideum by ''off-line'' liquid chromatography and mass spectrometry., PMID:24574058
Nephrin missense mutations: induction of endoplasmic reticulum stress and cell surface rescue by reduction in chaperone interactions., PMID:24303155
Endoplasmic reticulum glucosidases and protein quality control factors cooperate to establish biotrophy in Ustilago maydis., PMID:24280385
Response surface methodology based optimization of β-glucosidase production from Pichia pastoris., PMID:24081708
Deficiency of α-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans., PMID:23836288
Structure of a bacterial glycoside hydrolase family 63 enzyme in complex with its glycosynthase product, and insights into the substrate specificity., PMID:23826932
For research use only. Not for human or drug use.
