Catalog No.
YHA00201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp616-Leu854
Predicted molecular weight
29.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A4D1B5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GSAP, Gamma-secretase-activating protein, PION, Protein pigeon homolog, GSAP-16K
Tracing the GSAP-APP C-99 Interaction Site in the beta-Amyloid Pathway Leading to Alzheimer's Disease. PMID: 31299145
A Generic Software Architecture for Prognostics (GSAP). PMID: 32149002
Common GSAP promoter variant contributes to Alzheimer's disease liability. PMID: 25037285
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. PMID: 34156424
Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation. PMID: 30821607
The role of gamma-secretase activating protein (GSAP) and imatinib in the regulation of gamma-secretase activity and amyloid-beta generation. PMID: 23209290
Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway. PMID: 25533523
Pharmacological modulation of GSAP reduces amyloid-beta levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles. PMID: 24662099
Frontal Cortex and Hippocampal 纬-Secretase Activating Protein Levels in Prodromal Alzheimer Disease. PMID: 28743126
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. PMID: 20811458
Immunohistochemical characterization of 纬-secretase activating protein expression in Alzheimer's disease brains. PMID: 21718343
Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease. PMID: 25052851
In silico identification of natural product inhibitors for 纬-secretase activating protein, a therapeutic target for Alzheimer's disease. PMID: 30565717
Beta-Amyloid-Dependent miRNAs as Circulating Biomarkers in Alzheimer's Disease: a Preliminary Report. PMID: 32306293
MicroRNA-4422-5p as a Negative Regulator of Amyloidogenic Secretases: A Potential Biomarker for Alzheimer's Disease. PMID: 33836245
Purification and characterization of the human 纬-secretase activating protein. PMID: 22681044
A ginseng-specific abundant protein (GSAP) located on the cell wall is involved in abiotic stress tolerance. PMID: 17067765
Assembly of the presenilin 纬-/蔚-secretase complex. PMID: 22122073
Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. PMID: 27171516
Giant Splenic Artery Pseudoaneurysms: Two Case Reports and Cumulative Review of the Literature. PMID: 31676381
Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells. PMID: 32267716
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence. PMID: 26076991
PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway contributed to valvular calcification in rats with CKD. PMID: 33945189
Greedy Successive Anchorization for Localizing Machine Type Communication Devices. PMID: 27983576
Genome-wide identification of methylated CpG sites in nongenital cutaneous warts. PMID: 32641122
Proton myo-inositol cotransporter is a novel 纬-secretase associated protein that regulates A尾 production without affecting Notch cleavage. PMID: 26094765
Human brain proteins showing neuron-specific interactions with 纬-secretase. PMID: 25893612
CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice. PMID: 34809709
GATA1-mediated transcriptional regulation of the 纬-secretase activating protein increases A尾 formation in Down syndrome. PMID: 26448035
Erlin-2 is associated with active 纬-secretase in brain and affects amyloid 尾-peptide production. PMID: 22771797
Re-evaluating the measurement and influence of conscious movement processing on gait performance in older adults: Development of the Gait-Specific Attentional Profile. PMID: 32683216
Dielectrophoresis-Based Sample Handling in General-Purpose Programmable Diagnostic Instruments. PMID: 19684877
Alzheimer's disease: Selectively tuning gamma-secretase. PMID: 20811445
Dementia in 2010: Paving the way for Alzheimer disease drug development. PMID: 21297645
Imatinib methanesulfonate reduces hippocampal amyloid-尾 and restores cognitive function following repeated endotoxin exposure. PMID: 23665252
Characterization of methacrylated polysaccharides in combination with amine-based monomers for application in mortar. PMID: 28457438
Activation of the 纬-secretase complex and presence of 纬-secretase-activating protein may contribute to A尾42 production in sporadic inclusion-body myositis muscle fibers. PMID: 22750528
Environmental and physiological effects on grouping of drought-tolerant and susceptible rice varieties related to rice (Oryza sativa) root hydraulics under drought. PMID: 27192712
Sexual function and tunica albuginea wound healing following penile fracture: An 18-year follow-up study of 352 patients from Kermanshah, Iran. PMID: 19138357
New plaque-boosting protein a possible Alzheimer target. PMID: 20924003
Pontocerebellar Hypoplasia Maps to Chromosome 7q11.23: An Autopsy Case Report of a Novel Genetic Variant. PMID: 31885998
PROGRAMMABLE DIELECTROPHORETIC 渭TAS SAMPLE HANDLING. PMID: 23989046
Associations of circulating mediators of inflammation, cell regulation and immune response with esophageal squamous cell carcinoma. PMID: 34128078
Endoscopic retrograde cholangiopancreatography-induced acute pancreatitis often has a benign outcome. PMID: 16940887
Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. PMID: 9714300
[Cancellous grafting to the fibula in the treatment of type III open fractures]. PMID: 24193557
For research use only. Not for human or drug use.
