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Recombinant Human GSAP Protein, N-His

Catalog #:   YHA00201 Specific References (91) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: A4D1B5
Protein length: Asp616-Leu854
Overview

Catalog No.

YHA00201

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Asp616-Leu854

Predicted molecular weight

29.88 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

A4D1B5

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

GSAP, Gamma-secretase-activating protein, PION, Protein pigeon homolog, GSAP-16K

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human GSAP protein
References

Tracing the GSAP-APP C-99 Interaction Site in the beta-Amyloid Pathway Leading to Alzheimer's Disease. PMID: 31299145

A Generic Software Architecture for Prognostics (GSAP). PMID: 32149002

Common GSAP promoter variant contributes to Alzheimer's disease liability. PMID: 25037285

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. PMID: 34156424

Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation. PMID: 30821607

The role of gamma-secretase activating protein (GSAP) and imatinib in the regulation of gamma-secretase activity and amyloid-beta generation. PMID: 23209290

Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway. PMID: 25533523

Pharmacological modulation of GSAP reduces amyloid-beta levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles. PMID: 24662099

Frontal Cortex and Hippocampal 纬-Secretase Activating Protein Levels in Prodromal Alzheimer Disease. PMID: 28743126

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. PMID: 20811458

Immunohistochemical characterization of 纬-secretase activating protein expression in Alzheimer's disease brains. PMID: 21718343

Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease. PMID: 25052851

In silico identification of natural product inhibitors for 纬-secretase activating protein, a therapeutic target for Alzheimer's disease. PMID: 30565717

Beta-Amyloid-Dependent miRNAs as Circulating Biomarkers in Alzheimer's Disease: a Preliminary Report. PMID: 32306293

MicroRNA-4422-5p as a Negative Regulator of Amyloidogenic Secretases: A Potential Biomarker for Alzheimer's Disease. PMID: 33836245

Purification and characterization of the human 纬-secretase activating protein. PMID: 22681044

A ginseng-specific abundant protein (GSAP) located on the cell wall is involved in abiotic stress tolerance. PMID: 17067765

Assembly of the presenilin 纬-/蔚-secretase complex. PMID: 22122073

Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. PMID: 27171516

Giant Splenic Artery Pseudoaneurysms: Two Case Reports and Cumulative Review of the Literature. PMID: 31676381

Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells. PMID: 32267716

Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence. PMID: 26076991

PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway contributed to valvular calcification in rats with CKD. PMID: 33945189

Greedy Successive Anchorization for Localizing Machine Type Communication Devices. PMID: 27983576

Genome-wide identification of methylated CpG sites in nongenital cutaneous warts. PMID: 32641122

Proton myo-inositol cotransporter is a novel 纬-secretase associated protein that regulates A尾 production without affecting Notch cleavage. PMID: 26094765

Human brain proteins showing neuron-specific interactions with 纬-secretase. PMID: 25893612

CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice. PMID: 34809709

GATA1-mediated transcriptional regulation of the 纬-secretase activating protein increases A尾 formation in Down syndrome. PMID: 26448035

Erlin-2 is associated with active 纬-secretase in brain and affects amyloid 尾-peptide production. PMID: 22771797

Re-evaluating the measurement and influence of conscious movement processing on gait performance in older adults: Development of the Gait-Specific Attentional Profile. PMID: 32683216

Dielectrophoresis-Based Sample Handling in General-Purpose Programmable Diagnostic Instruments. PMID: 19684877

Alzheimer's disease: Selectively tuning gamma-secretase. PMID: 20811445

Dementia in 2010: Paving the way for Alzheimer disease drug development. PMID: 21297645

Imatinib methanesulfonate reduces hippocampal amyloid-尾 and restores cognitive function following repeated endotoxin exposure. PMID: 23665252

Characterization of methacrylated polysaccharides in combination with amine-based monomers for application in mortar. PMID: 28457438

Activation of the 纬-secretase complex and presence of 纬-secretase-activating protein may contribute to A尾42 production in sporadic inclusion-body myositis muscle fibers. PMID: 22750528

Environmental and physiological effects on grouping of drought-tolerant and susceptible rice varieties related to rice (Oryza sativa) root hydraulics under drought. PMID: 27192712

Sexual function and tunica albuginea wound healing following penile fracture: An 18-year follow-up study of 352 patients from Kermanshah, Iran. PMID: 19138357

New plaque-boosting protein a possible Alzheimer target. PMID: 20924003

Pontocerebellar Hypoplasia Maps to Chromosome 7q11.23: An Autopsy Case Report of a Novel Genetic Variant. PMID: 31885998

PROGRAMMABLE DIELECTROPHORETIC 渭TAS SAMPLE HANDLING. PMID: 23989046

Associations of circulating mediators of inflammation, cell regulation and immune response with esophageal squamous cell carcinoma. PMID: 34128078

Endoscopic retrograde cholangiopancreatography-induced acute pancreatitis often has a benign outcome. PMID: 16940887

Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. PMID: 9714300

[Cancellous grafting to the fibula in the treatment of type III open fractures]. PMID: 24193557

Room-temperature curing high-strength, water-resistant, flame-retardant adhesive based on aluminum dihydrogen phosphate and gelatinized starch cross-linking., PMID:40015415

A new bithiophene inhibited amyloid-β accumulation and enhanced cognitive function in the hippocampus of aluminum-induced Alzheimer's disease in adult rats., PMID:39497290

Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer's Disease., PMID:38868092

Genetic Basis of Pigment Dispersion Syndrome and Pigmentary Glaucoma: An Update and Functional Insights., PMID:38397132

Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia., PMID:37366533

To Explore the Binding Affinity of Human γ-Secretase Activating Protein (GSAP) Isoform 4 with APP-C99 Peptides., PMID:37065030

Mechanisms of miR-29a-5p involvement in osteogenic phenotype transformation and cellular regulation of vascular smooth muscle and thus influencing calcification in VSMCs in chronic kidney disease., PMID:36495508

Targeting apoptosis in MCF-7 and Ehrlich ascites carcinoma cells by saponifiable fractions from green and black Vitis vinifera seed oil., PMID:36395612

rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits., PMID:35577986

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation., PMID:35298330

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs., PMID:35032184

Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development., PMID:35031440

CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice., PMID:34809709

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease., PMID:34156424

Associations of circulating mediators of inflammation, cell regulation and immune response with esophageal squamous cell carcinoma., PMID:34128078

PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway contributed to valvular calcification in rats with CKD., PMID:33945189

MicroRNA-4422-5p as a Negative Regulator of Amyloidogenic Secretases: A Potential Biomarker for Alzheimer's Disease., PMID:33836245

Beta-Amyloid-Dependent miRNAs as Circulating Biomarkers in Alzheimer's Disease: a Preliminary Report., PMID:32306293

Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells., PMID:32267716

Tracing the GSAP-APP C-99 Interaction Site in the β-Amyloid Pathway Leading to Alzheimer's Disease., PMID:31299145

GSAP modulates γ-secretase specificity by inducing conformational change in PS1., PMID:30850537

Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation., PMID:30821607

In silico identification of natural product inhibitors for γ-secretase activating protein, a therapeutic target for Alzheimer's disease., PMID:30565717

Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease., PMID:28743126

GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome., PMID:26448035

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage., PMID:26094765

Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence., PMID:26076991

Human brain proteins showing neuron-specific interactions with γ-secretase., PMID:25893612

Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway., PMID:25533523

Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease., PMID:25052851

Common GSAP promoter variant contributes to Alzheimer's disease liability., PMID:25037285

Pharmacological modulation of GSAP reduces amyloid-β levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles., PMID:24662099

Imatinib methanesulfonate reduces hippocampal amyloid-β and restores cognitive function following repeated endotoxin exposure., PMID:23665252

The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation., PMID:23209290

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production., PMID:22771797

Activation of the γ-secretase complex and presence of γ-secretase-activating protein may contribute to Aβ42 production in sporadic inclusion-body myositis muscle fibers., PMID:22750528

Purification and characterization of the human γ-secretase activating protein., PMID:22681044

Assembly of the presenilin γ-/ε-secretase complex., PMID:22122073

Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains., PMID:21718343

Dementia in 2010: Paving the way for Alzheimer disease drug development., PMID:21297645

New plaque-boosting protein a possible Alzheimer target., PMID:20924003

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease., PMID:20811458

Alzheimer's disease: Selectively tuning gamma-secretase., PMID:20811445

A ginseng-specific abundant protein (GSAP) located on the cell wall is involved in abiotic stress tolerance., PMID:17067765

Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse., PMID:9714300

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human GSAP Protein, N-His [YHA00201]
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