Catalog No.
YHD49801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys227
Predicted molecular weight
26.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22061
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PIMT, L-isoaspartyl protein carboxyl methyltransferase, PCMT1, Protein-L-isoaspartate(D-aspartate) O-methyltransferase, Protein L-isoaspartyl/D-aspartyl methyltransferase, Protein-beta-aspartate methyltransferase
Madecassoside exerts anti-neurodegeneration effects in protein l-isoaspartyl methyltransferase deficient mice via targeting PRDX2-mediated oxidative stress and inflammation., PMID:40482841
Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase., PMID:40475564
Knockdown of BAP31 Suppresses Tumorigenesis and Stemness in Breast Cancer Cells via the Hippo Pathway., PMID:40332113
Multi-omics Analysis Sheds Light on the Extracellular Role of PCMT1., PMID:40287848
Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis., PMID:40204712
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates., PMID:40196534
Single-cell sequencing exposes mast cell-derived CD52's anti-tumor action in breast cancer through the IL-6/JAK/STAT3 axis., PMID:40194575
Circular RNA circCLASP2 promotes nasopharyngeal carcinoma progression through binding to DHX9 to enhance PCMT1 translation., PMID:40050914
Repair of Isoaspartyl Residues by PCMT1 and Kidney Fibrosis., PMID:40036072
Aspartate Isomerization Regulates in Situ Assembly of Peptides into Supramolecular Probes for Detection of Protein Carboxyl Methyltransferase in Bladder Cancer., PMID:40016095
Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage., PMID:39641635
PCMT1 confirmed as a pan-cancer immune biomarker and a contributor to breast cancer metastasis., PMID:39267673
PCMT1 as a prognostic marker in breast cancer., PMID:39235556
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy., PMID:39152475
Silencing PCMT1 enhances the sensitivity of breast cancer cells to paclitaxel through the PI3K/Akt/STMN1 pathway., PMID:38853025
Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy., PMID:38234807
Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration., PMID:38181970
[Prognostic Value of PCMT1 Expression in Gastric Cancer and Its Regulatory Effect on Spindle Assembly Checkpoints]., PMID:38162070
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus., PMID:37994408
Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation., PMID:37971164
PCMT1 knockdown attenuates malignant properties by globally regulating transcriptome profiles in triple-negative breast cancer cells., PMID:37953789
PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway., PMID:37899170
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers., PMID:37875819
PCMT1 is a potential target related to tumor progression and immune infiltration in liver cancer., PMID:37596654
The Role of Protein-L-isoaspartyl Methyltransferase (PIMT) in the Suppression of Toxicity of the Oligomeric Form of Aβ42, in Addition to the Inhibition of Its Fibrillization., PMID:37535852
In vitro Anti-malignant Property of PCMT1 Silencing and Identification of the SNHG16/miR-195/PCMT1 Regulatory Axis in Breast Cancer Cells., PMID:36639265
Elevated expression of protein-L-isoaspartate O-methyltransferase-1 (PCMT1) in cervical cancer., PMID:36093534
Identification of Hub Genes Associated With the Development of Stomach Adenocarcinoma by Integrated Bioinformatics Analysis., PMID:35686089
The Protein L-Isoaspartyl (D-Aspartyl) Methyltransferase Regulates Glial-to-Mesenchymal Transition and Migration Induced by TGF-β1 in Human U-87 MG Glioma Cells., PMID:35628507
PCMT1 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltrates in Breast Cancer., PMID:35535040
Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins., PMID:35486881
PIMT/TGS1: An evolving metabolic molecular switch with conserved methyl transferase activity., PMID:35462043
Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis., PMID:35033172
A Novel Gene Prognostic Signature Based on Differential DNA Methylation in Breast Cancer., PMID:34956313
Identification of the Upregulation of MRPL13 as a Novel Prognostic Marker Associated with Overall Survival Time and Immunotherapy Response in Breast Cancer., PMID:34868337
Differential expression of microRNAs associated with neurodegenerative diseases and diabetic nephropathy in protein l-isoaspartyl methyltransferase-deficient mice., PMID:34314072
The enzyme L-isoaspartyl (D-aspartyl) methyltransferase promotes migration and invasion in human U-87 MG and U-251 MG glioblastoma cell lines., PMID:34082401
LINC00511/miRNA-143-3p Modulates Apoptosis and Malignant Phenotype of Bladder Carcinoma Cells via PCMT1., PMID:33898446
Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis., PMID:33831670
l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain., PMID:33552132
PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity., PMID:33198416
Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells., PMID:33054131
Neural stem cell conditioned medium alleviates Aβ25-35 damage to SH-SY5Y cells through the PCMT1/MST1 pathway., PMID:32705859
Protein Kinase C Theta Modulates PCMT1 through hnRNPL to Regulate FOXP3 Stability in Regulatory T Cells., PMID:32592691
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase., PMID:31785325
The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation., PMID:31239355
New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation., PMID:29856810
PIMT/NCOA6IP Deletion in the Mouse Heart Causes Delayed Cardiomyopathy Attributable to Perturbation in Energy Metabolism., PMID:29772707
PCMT1 is an unfavorable predictor and functions as an oncogene in bladder cancer., PMID:29517839
Neuroprotective Effects of CGP3466B on Apoptosis Are Modulated by Protein-L-isoaspartate (D-aspartate) O-methyltransferase/Mst1 Pathways after Traumatic Brain Injury in Rats., PMID:28835703
For research use only. Not for human or drug use.
