Catalog No.
YHG20702
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu1351-Ile1601
Predicted molecular weight
31.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q09472
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone crotonyltransferase p300, Protein lactyltransferas p300, Protein propionyltransferase p300, Histone acetyltransferase p300, Protein 2-hydroxyisobutyryltransferase p300, EP300, p300 HAT, Histone butyryltransferase p300, P300, E1A-associated protein p300
Mechanism of Ginsenosides in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking., PMID:40508108
The lactylation-immune regulatory axis: a potential therapeutic target for migraine prevention and treatment., PMID:40468199
Resistance to the KRASG12D Inhibitor MRTX1133 is Associated with Increased Sensitivity to BET Inhibition., PMID:40463163
Targeting EP300 in diffuse large b-cell lymphoma: efficacy of A485 and synergistic effects with XPO1 inhibition., PMID:40437414
A Novel EP300 Variant in an African American Girl With Global Developmental Delay and Leukemia., PMID:40421630
(+)-a-Longipinene alleviates murine laser-induced choroidal neovascularization: Evidence from in vivo and in vitro experiments., PMID:40412129
Machine learning explores the prognostic and immuno-oncological impact of mitochondrial unfolded protein response in CESC., PMID:40410615
CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition., PMID:40393984
TCF3::ZNF384 induces steroid resistance in B-cell precursor acute lymphoblastic leukemia cells., PMID:40391410
ca-circSCN8A Promotes HPASMCs Ferroptosis via LLPS Initiated R-Loop., PMID:40384439
KDM6A, ARID1A and SETD2 loss-of-function mutations as prognostic biomarkers and their association with sites of metastatic progression in locally-advanced, recurrent or metastatic adenoid cystic carcinoma., PMID:40381467
VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300., PMID:40338073
[Transcriptomic analysis of key genes involved in sex differences in intellectual development]., PMID:40326065
Modulating Cancer Stem Cell Characteristics in CD133+ Melanoma Cells through Hif1α, KLF4, and SHH Silencing., PMID:40321496
The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription., PMID:40319015
HDAC1 is involved in the destabilization of the HSF2 protein under nonstress and stress conditions., PMID:40318841
Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory., PMID:40318634
Further Delineation of the AUTS2 HX Repeat Domain-Related Phenotype., PMID:40317680
CITED2 Binding to EP300 Regulates Human Spermatogonial Stem Cell Proliferation and Survival Through HSPA6., PMID:40313859
Identification of Hub Genes for Dexmedetomidine Alleviation of Limb Ischemia-Reperfusion-Induced Lung Injury in Rats by Transcriptomic., PMID:40297546
The mechanism of Weiqi decoction treating gastric cancer: a work based on network pharmacology and experimental verification., PMID:40259338
ATF4:p52 complex activates oncogenic enhancers in multiple myeloma via p300/CBP recruitment to regulate BACH1., PMID:40250789
P300 regulates Melanophilin expression by modulating TFAP2A binding through histone acetylation., PMID:40246651
Impact of fish oil on epigenetic regulation in perirenal adipose tissue of obese mice., PMID:40246605
Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse., PMID:40244695
Multi-zonal liver organoids from human pluripotent stem cells., PMID:40240593
Preliminary exploration of the potential role of salvianolic acid F in regulating ovarian cancer cell proliferation, migration, invasion, and apoptosis and its association with the EP300/PI3K/AKT pathway., PMID:40237524
The physiological and transcriptional differences between golden and brown noble scallops Chlamys nobilis., PMID:40199050
Evaluating the Mechanism Underlying Multi-Compound Synergy of Banxia Decoction in the Treatment of Hashimoto's Thyroiditis Based on Network Pharmacology and Molecular Docking., PMID:40196382
Brain Abnormalities in Prenatally Diagnosed Rubinstein-Taybi Syndrome., PMID:40195020
Acetylation of H3K18 activated by p300 promotes osteogenesis in human adipose-derived mesenchymal stem cells., PMID:40164340
Rubinstein-Taybi syndrome with ganglioneuroblastoma: a case report and literature review., PMID:40159473
Recent Advances in CBP/EP300 Degraders., PMID:40156557
Lactate accumulation drives hepatocellular carcinoma metastasis through facilitating tumor-derived exosome biogenesis by Rab7A lactylation., PMID:40120799
Transcription factor EP300 targets SIRT5 to promote autophagy of nucleus pulposus cells and attenuate intervertebral disc degeneration., PMID:40096894
EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus-Positive Hepatocellular Carcinoma Cells., PMID:40095759
Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement., PMID:40090010
KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells., PMID:40082673
Advancing Understanding and Therapeutic Strategies for NUT Sarcomas: Comprehensive Review of the Literature and Two Cases., PMID:40070529
Network pharmacology and molecular docking to reveal the pharmacological mechanisms of Abelmoschus esculentus (l.) moench in treating breast cancer., PMID:40061631
Salvianolic acid B ameliorates hepatic fibrosis via inhibiting p300/CBP., PMID:40058756
An Attention-Aware Multi-Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia., PMID:40045692
Whole-exome sequencing identifies EP300 variants associated with visceral leishmaniasis relapse., PMID:40020829
Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis., PMID:40010102
Comparative Transcriptomics Analysis of Foot-and-Mouth Disease Virus-Infected Cell Model Systems., PMID:40005867
DYRK1A Up-Regulation Specifically Impairs a Presynaptic Form of Long-Term Potentiation., PMID:40003558
Histone lactylation-driven B7-H3 expression promotes tumor immune evasion., PMID:39990209
Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation., PMID:39981920
Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology studies., PMID:39973828
Discovery of niclosamide as a p300/transcription factor protein-protein interaction inhibitor., PMID:39970485
For research use only. Not for human or drug use.
