Catalog No.
DHK10006
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor, TAG-72, STn
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P55899 & ChEBI: 36543
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Bispecific, MDX 220, MDX-220
Clone ID
MDX-220
Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway., PMID:40505347
[Prediction of immunotherapy targets for chronic cerebral hypoperfusion by bioinformatics method]., PMID:40288982
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway., PMID:40124052
A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity., PMID:40020261
Establishment of a Panel of Human Cell Lines to Identify Cellular Receptors Used by Enteroviruses to Infect Cells., PMID:39940693
Population Pharmacokinetic Model of Intravenous Immunoglobulin in Patients Treated for Various Immune System Disorders., PMID:39366801
Exploring resveratrol against Alzheimer's disease and Parkinson's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vitro., PMID:39328512
Neonatal Fc receptor is a functional receptor for classical human astrovirus., PMID:39266307
Rhesus Macaques: VNTR Polymorphism of the FCGRT Gene., PMID:39134810
Identifying the immunoglobulin G transporter in equine tissues: A look at the neonatal Fc receptor., PMID:38879095
Characterizing Common and Rare Variations in Nontraditional Glycemic Biomarkers Using Multivariate Approaches on Multiancestry ARIC Study., PMID:38869630
Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy., PMID:38205888
Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia., PMID:38145833
FcRn Expression in Endometrial Cancer and Its Association with Clinicopathologic Features., PMID:38132243
Genome-wide association study for reproduction traits in Colombian Creole Blanco Orejinegro cattle., PMID:38044379
The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking., PMID:37565427
Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels., PMID:37128921
Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas., PMID:37077920
Allele mining in gene encoding fc fragment of IgG receptor, transporter, alpha (FCGRT) and association of nucleotide variants with passive transfer of immunity in neonatal buffalo calves., PMID:36757548
Bioinformatics Analysis of Immune Cell Infiltration and Diagnostic Biomarkers between Ankylosing Spondylitis and Inflammatory Bowel Disease., PMID:36643579
2'-Fucosyllactose Inhibits Coxsackievirus Class A Type 9 Infection by Blocking Virus Attachment and Internalisation., PMID:36430203
Neutrophil-related genes predict prognosis and response to immune checkpoint inhibitors in bladder cancer., PMID:36339597
Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant HLADQA1*05G>A Genotype., PMID:36112504
Single-cell RNA sequencing reveals distinct immunology profiles in human keloid., PMID:35990663
Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18., PMID:35862785
Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia., PMID:35841099
Next-Generation Sequencing analysis discloses genes implicated in equine endometrosis that may lead to tumorigenesis., PMID:35760027
Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids., PMID:35579465
Altered gene expression and PTSD symptom dimensions in World Trade Center responders., PMID:35177824
Detection of nucleotide variants in FCGRT (Fc fragment of IgG, receptor, transporter, alpha) gene and their influence on colostral IgG concentration in Indian water buffalo (Bubalus bubalis)., PMID:35152368
An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript., PMID:34753797
Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans., PMID:34514376
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21)., PMID:34040082
Unearthing of Key Genes Driving the Pathogenesis of Alzheimer's Disease via Bioinformatics., PMID:33936168
Animal models for SARS-Cov2/Covid19 research-A commentary., PMID:33812856
The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors., PMID:33717213
VNTR2/VNTR3 genotype in the FCGRT gene is associated with reduced effectiveness of intravenous immunoglobulin in patients with myasthenia gravis., PMID:33552238
Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:33460483
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice., PMID:33025844
Megalin-mediated albumin endocytosis in cultured murine mesangial cells., PMID:32736701
Bioinformatics profiling identifies seven immune-related risk signatures for hepatocellular carcinoma., PMID:32518711
Prognostic Value of a Stemness Index-Associated Signature in Primary Lower-Grade Glioma., PMID:32431729
The neonatal Fc receptor in cancer FcRn in cancer., PMID:32368865
Transcriptome analysis of HPV-induced warts and healthy skin in humans., PMID:32151264
Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium., PMID:31209240
Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B., PMID:31104841
Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment., PMID:30323819
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex., PMID:29306331
Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181., PMID:29302759
For research use only. Not for human or drug use.
