Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease., PMID:39998162
Unveiling the Group A Streptococcus Vaccine-Based L-Rhamnose from Backbone of Group A Carbohydrate: Current Insight Against Acute Rheumatic Fever to Reduce the Global Burden of Rheumatic Heart Disease., PMID:39959434
Influence of component structural arrangement on cholesterol-antigen conjugate immunogenicity and antisera bactericidal activity against group A Streptococcus., PMID:39952060
A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers., PMID:39563457
Serological Responses to Target Streptococcus pyogenes Vaccine Antigens in Patients With Proven Invasive β-Hemolytic Streptococcal Infections., PMID:39383256
An acute rheumatic fever immune signature comprising inflammatory markers, IgG3, and Streptococcus pyogenes-specific antibodies., PMID:39184444
Immunogenicity of a 30-valent M protein mRNA group A Streptococcus vaccine., PMID:39141987
The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies., PMID:38678029
Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model., PMID:38675764
Quantification of Adaptive Immune Responses Against Protein-Binding Interfaces in the Streptococcal M1 Protein., PMID:38527648
Streptococcal Toxic Shock Syndrome Caused by a Streptococcus pyogenes emm22 Genotype with a CsrS Mutation: a Case Report., PMID:38417865
Molecular characterization of the interaction between human IgG and the M-related proteins from Streptococcus pyogenes., PMID:38176650
SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions., PMID:37872175
Naturally acquired functional antibody responses to group A Streptococcus differ between major strain types., PMID:37729548
Insertion of an immunodominant T helper cell epitope within the Group A Streptococcus M protein promotes an IFN-γ-dependent shift from a non-protective to a protective immune response., PMID:37654501
Structure-guided design of a broadly cross-reactive multivalent group a streptococcal vaccine., PMID:37596198
A conserved 3D pattern in a Streptococcus pyogenes M protein immunogen elicits M-type crossreactivity., PMID:37390991
Serum Immune Responses to Group A Streptococcal Antigens following Pharyngeal Acquisitions among Children in Cape Town, South Africa., PMID:37154726
IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes., PMID:36815140
Multicomponent Vaccines against Group A Streptococcus Can Effectively Target Broad Disease Presentations., PMID:34579262
Peptide-Protein Conjugation and Characterization to Develop Vaccines for Group A Streptococcus., PMID:34386947
Poly(hydrophobic amino acid) Conjugates for the Delivery of Multiepitope Vaccine against Group A Streptococcus., PMID:34379392
A Predictive Model of Antibody Binding in the Presence of IgG-Interacting Bacterial Surface Proteins., PMID:33828549
Cross-reactive immunogenicity of group A streptococcal vaccines designed using a recurrent neural network to identify conserved M protein linear epitopes., PMID:33642159
Nonimmune antibody interactions of Group A Streptococcus M and M-like proteins., PMID:33630944
Prime-Pull Immunization with a Bivalent M-Protein and Spy-CEP Peptide Vaccine Adjuvanted with CAF®01 Liposomes Induces Both Mucosal and Peripheral Protection from covR/S Mutant Streptococcus pyogenes., PMID:33622722
Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology., PMID:33411763
Characterisation of clinical manifestations and treatment strategies for invasive beta-haemolytic streptococcal infections in a Swiss tertiary hospital., PMID:33277914
A novel aspect may explain the mechanisms of pathogenicity of rheumatic fever, a multifactorial, autoimmune, infectious and inflammatory disorder which "licks the joints and bites the heart": A working hypothesis., PMID:33254529
M-protein based vaccine induces immunogenicity and protection from Streptococcus pyogenes when delivered on a high-density microarray patch (HD-MAP)., PMID:32802413
Immunotherapy targeting the Streptococcus pyogenes M protein or streptolysin O to treat or prevent influenza A superinfection., PMID:32574205
Structure-based group A streptococcal vaccine design: Helical wheel homology predicts antibody cross-reactivity among streptococcal M protein-derived peptides., PMID:32029479
Safety and immunogenicity of a 30-valent M protein-based group a streptococcal vaccine in healthy adult volunteers: A randomized, controlled phase I study., PMID:31843270
Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections., PMID:31748786
Antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA-humanized mice., PMID:31517054
The Limitations of the Rheumatogenic Concept for Group A Streptococcus: Systematic Review and Genetic Analysis., PMID:31334754
Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system., PMID:31247372
The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus., PMID:31214187
Vaccine Approaches To Protect against Group A Streptococcal Pharyngitis., PMID:31111819
Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model., PMID:31062619
Development of an Opsonophagocytic Killing Assay Using HL-60 Cells for Detection of Functional Antibodies against Streptococcus pyogenes., PMID:30567901
Complement Activation Occurs at the Surface of Platelets Activated by Streptococcal M1 Protein and This Results in Phagocytosis of Platelets., PMID:30541884
Clinical and microbiological response of mice to intranasal inoculation with Lactococcus lactis expressing Group A Streptococcus antigens, to be used as an anti-streptococcal vaccine., PMID:30357922
Development of an opsonophagocytic killing assay for group a streptococcus., PMID:29776751
Protein adhesins as vaccine antigens for Group A Streptococcus., PMID:29718270
Protective immunity induced by an intranasal multivalent vaccine comprising 10 Lactococcus lactis strains expressing highly prevalent M-protein antigens derived from Group A Streptococcus., PMID:29704396
Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion., PMID:29626087
Group G Streptococcus Induces an Autoimmune Carditis Mediated by Interleukin 17A and Interferon γ in the Lewis Rat Model of Rheumatic Heart Disease., PMID:29236994
Physicochemical characterisation, immunogenicity and protective efficacy of a lead streptococcal vaccine: progress towards Phase I trial., PMID:29062085
Immune Cross-Opsonization Within emm Clusters Following Group A Streptococcus Skin Infection: Broadening the Scope of Type-Specific Immunity., PMID:29020160
For research use only. Not for human or drug use.
