Catalog No.
PME79101
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse PPT1 (Asp28-Lys306).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Palmitoyl-protein thioesterase 1, PPT-1, 3.1.2.22, Palmitoyl-protein hydrolase 1, Ppt1, Cln1, Ppt
Purification
Purified by antigen affinity column.
Accession
O88531
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
MXene-rGO nanocomposite based electrochemical immunosensor for detection of endosulfan - An organochlorine pesticide., PMID:39708952
Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations., PMID:38984665
Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice., PMID:38169466
Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8+ Lymphocyte Repopulation in Hepatocellular Carcinoma., PMID:38133710
Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma., PMID:37385725
Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme., PMID:36324638
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms., PMID:36284469
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma., PMID:36278493
Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation., PMID:34224732
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma., PMID:32780726
Palmitoyl-protein thioesterase 1 (PPT1): an obesity-induced rat testicular marker of reduced fertility., PMID:24302477
Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis., PMID:22704978
Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from INCL patients., PMID:21704547
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37., PMID:18922470
Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction., PMID:17656100
Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons., PMID:17565660
Two novel CLN5 mutations in a Portuguese patient with vLINCL: insights into molecular mechanisms of CLN5 deficiency., PMID:16814585
Overexpression in colorectal carcinoma of two lysosomal enzymes, CLN2 and CLN1, involved in neuronal ceroid lipofuscinosis., PMID:16518810
Expression cloning screen for modifiers of amyloid precursor protein shedding., PMID:16446073
Neuronal trafficking of palmitoyl protein thioesterase provides an excellent model to study the effects of different mutations which cause infantile neuronal ceroid lipofuscinocis., PMID:11520175
Identification, isolation and biochemical characterization of a phosphopantetheine:protein transferase that activates the two type-I fatty acid synthases of Brevibacterium ammoniagenes., PMID:9346306
A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus., PMID:7925273
For research use only. Not for human or drug use.
