Anti-Mouse CTSK Polyclonal Antibody

Catalog No.

PME40301

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CTSK (Thr82-Met329).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Cathepsin K, 3.4.22.38, Ctsk

Purification

Purified by antigen affinity column.

Accession

P55097

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Effects of Systemic and Local Anti-tumor Necrosis Factor-α Receptor-1 Administration on Periapical Bone Loss in Mice., PMID:40374034

The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis., PMID:36003376

SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis., PMID:35553634

Gegen Qinlian Decoction ameliorates type 2 diabetes osteoporosis via IGFBP3/MAPK/NFATc1 signaling pathway based on cytokine antibody array., PMID:34798519

Cathepsin K is Superior to HMB45 for the Diagnosis of Pulmonary Lymphangioleiomyomatosis., PMID:34433182

The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K., PMID:34183355

The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice., PMID:34071318

Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH., PMID:34043707

Cathepsin K (Clone EPR19992) Demonstrates Uniformly Positive Immunoreactivity in Renal Oncocytoma, Chromophobe Renal Cell Carcinoma, and Distal Tubules., PMID:33764165

Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes., PMID:33148174

Lupus-like Disease in FcγRIIB-/- Mice Induces Osteopenia., PMID:31758072

Glycolaldehyde-modified advanced glycation end-products inhibit differentiation of human monocytes into osteoclasts via upregulation of IL-10., PMID:31421252

Multitarget-based cotreatment with cilostazol and celecoxib synergistically suppresses collagen-induced arthritis in mice by enhancing interleukin-10 expression., PMID:31170675

TIMP Loss Activates Metalloproteinase-TNFα-DKK1 Axis To Compromise Wnt Signaling and Bone Mass., PMID:30216540

Levetiracetam mitigates lipopolysaccharide-induced JAK2/STAT3 and TLR4/MAPK signaling pathways activation in a rat model of adjuvant- induced arthritis., PMID:29501867

Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia., PMID:29083055

Development of a New Immunoassay for Human Cathepsin K-Generated Periostin Fragments as a Serum Biomarker for Cortical Bone., PMID:28725907

Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients., PMID:28626969

Xp11 Translocation Renal Cell Carcinomas (RCCs) With RBM10-TFE3 Gene Fusion Demonstrating Melanotic Features and Overlapping Morphology With t(6;11) RCC: Interest and Diagnostic Pitfall in Detecting a Paracentric Inversion of TFE3., PMID:28288037

Increased osteoclastogenesis in patients with vertebral fractures following discontinuation of denosumab treatment., PMID:28283537

Autocrine and paracrine STIP1 signaling promote osteolytic bone metastasis in renal cell carcinoma., PMID:28199984

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis., PMID:26311062

Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation., PMID:26141367

Abundance of MMPs and cysteine cathepsins in caries-affected dentin., PMID:24356440

Osteoclast-like multinucleated giant cells in sinonasal inflammation of granulomatosis with polyangiitis (Wegener's granulomatosis)., PMID:23465045

Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production., PMID:21360521

Cathepsin K-upregulation in fibroblasts promotes matrigel invasive ability of squamous cell carcinoma cells via tumor-derived IL-1α., PMID:21146373

New treatment targets in osteoporosis., PMID:20381400

Future therapeutic targets in osteoporosis., PMID:19461517

[Drugs under development for osteoporosis ]., PMID:19432120

Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro., PMID:19118660

Regulation of cathepsin X overexpression in H. pylori-infected gastric epithelial cells and macrophages., PMID:19090485

Anti-resorptive therapies for osteoporosis., PMID:18760372

Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy., PMID:18674944

Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage., PMID:18511517

[Bony lesion with prostate cancer]., PMID:18379023

[Assessment of bone quality. Drug developments for restoring bone mass and quality in the treatment of osteoporosis]., PMID:18310826

Trigger osteoclast formation and activation: molecular treatment strategy of delayed tooth eruption., PMID:17560733

Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation., PMID:17133594

Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls., PMID:17112299

Developments in the pharmacotherapeutic management of osteoporosis., PMID:16872263

Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells., PMID:16774752

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer., PMID:16707449

NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K., PMID:16680826

The relative merits of anabolics versus anti-resorptive compounds: where our targets should be, and whether we are addressing them., PMID:16650802

cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts., PMID:16644480

Human osteoblasts produce cathepsin K., PMID:16337236

Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro., PMID:16304045

Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues., PMID:15878337

Capturing protein interactions in the secretory pathway of living cells., PMID:15849265

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