Catalog No.
YMN53101
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser329-Arg399
Predicted molecular weight
35.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99JZ7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein homolog, MIG-6, Errfi1, Mig6
A crucial role of miR-155 in the pathomechanism of acute kidney injury., PMID:40308762
Harnessing single-cell and multi-omics insights: STING pathway-based predictive signature for immunotherapy response in lung adenocarcinoma., PMID:40308576
miR-126-3p Serves as a Biomarker for Hepatitis B Virus-Associated Chronic Acute Liver Failure and Regulates Inflammation by Regulating ERRFI1., PMID:40227026
EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer., PMID:39905540
Construction of ceRNA Network and Disease Diagnosis Model for Keloid Based on Tumor Suppressor ERRFI1., PMID:39563082
Identifying a CD8T cell signature in the tumor microenvironment to forecast gastric cancer outcomes from sequencing data., PMID:39554559
Mutations in Mig6 reduce inhibition of the epidermal growth factor receptor., PMID:39548957
MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer., PMID:39244004
Functional loss of ERBB receptor feedback inhibitor 1 (MIG6) promotes glioblastoma tumorigenesis by aberrant activation of epidermal growth factor receptor (EGFR)., PMID:39129344
Potentially functional variants of ERRFI1 in hypoxia-related genes predict survival of non-small cell lung cancer patients., PMID:39096122
ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner., PMID:38862918
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m6A-dependent manner., PMID:38380598
MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC through EGFR activation by low-dose EGF., PMID:37917191
Intervention of AXL in EGFR Signaling via Phosphorylation and Stabilization of MIG6 in Non-Small Cell Lung Cancer., PMID:37834326
MIG6 Mediates Adaptive and Acquired Resistance to ALK/ROS1 Fusion Kinase Inhibition through EGFR Bypass Signaling., PMID:37748191
Role of ErbB and IL-1 signaling pathways in the dermonecrotic lesion induced by Loxosceles sphingomyelinases D., PMID:37707622
Exploring shared pathways and the shared biomarker ERRFI1 in Obstructive sleep apnoea and atherosclerosis using integrated bioinformatics analysis., PMID:37699925
Chromatin architectural factor CTCF is essential for progesterone-dependent uterine maturation., PMID:37489832
The increased expression of cytokeratin 13 leads to an increase in radiosensitivity of nasopharyngeal carcinoma HNE-3 cells by upregulating ERRFI1., PMID:37070291
Pancreatic loss of Mig6 alters murine endocrine cell fate and protects functional beta cell mass in an STZ-induced model of diabetes., PMID:37066257
Feedback activation of EGFR/wild-type RAS signaling axis limits KRASG12D inhibitor efficacy in KRASG12D-mutated colorectal cancer., PMID:37020035
Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced transformation of human bronchial epithelial cells depends on the length of exposure., PMID:36715065
Coupled folding-upon-binding of human tumor suppressor MIG6 to lung cancer EGFR kinase domain and molecular trimming/stapling of MIG6-derived β-hairpins to target the coupling event., PMID:36547692
Vemurafenib inhibits immune escape biomarker BCL2A1 by targeting PI3K/AKT signaling pathway to suppress breast cancer., PMID:36524001
MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer., PMID:36498921
Transcriptome Changes in Glioma Cells Cultivated under Conditions of Neurosphere Formation., PMID:36231068
Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region., PMID:36178070
Effect of Autolyzed Yarrowia lipolytica on the Growth Performance, Antioxidant Capacity, Intestinal Histology, Microbiota, and Transcriptome Profile of Juvenile Largemouth Bass (Micropterus salmoides)., PMID:36142687
Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma., PMID:36108156
Androgen-Induced MIG6 Regulates Phosphorylation of Retinoblastoma Protein and AKT to Counteract Non-Genomic AR Signaling in Prostate Cancer Cells., PMID:36008945
Reiterative modeling of combined transcriptomic and proteomic features refines and improves the prediction of early recurrence in squamous cell carcinoma of head and neck., PMID:36007290
Identification of a combined apoptosis and hypoxia gene signature for predicting prognosis and immune infiltration in breast cancer., PMID:35441810
Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments., PMID:35405299
KLF4 Affects Acute Renal Allograft Injury via Binding to MicroRNA-155-5p Promoter to Regulate ERRFI1., PMID:35340414
Serum MIG6 concentration is increased by cholesterol-lowering treatment in patients with type 2 diabetes mellitus and hypercholesterolemia., PMID:35301888
Loss of MIG-6 results in endometrial progesterone resistance via ERBB2., PMID:35232969
Mig-6 Inhibits Autophagy in HCC Cell Lines by Modulating miR-193a-3p., PMID:35165519
Mig-6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma., PMID:34845855
Molecular insight into the affinity, specificity and cross-reactivity of systematic hepatocellular carcinoma RALT interaction profile with human receptor tyrosine kinases., PMID:34618235
Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma., PMID:34433654
Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue., PMID:34358969
Mig6 not only inhibits EGFR and HER2 but also targets HER3 and HER4 in a differential specificity: Implications for targeted esophageal cancer therapy., PMID:34293452
Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases., PMID:34206547
Molecular conversion of MIG6 hotspot-3 peptide from the nonbinder to a moderate binder of HER2 by rational design of an orthogonal interaction system at the HER2-peptide interface., PMID:34077816
A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements., PMID:33986153
Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs., PMID:33853673
A novel tp53-associated nomogram to predict the overall survival in patients with pancreatic cancer., PMID:33789615
MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer., PMID:33655623
Changing Expression Profiles and Inclination to Competing Endogenous RNA Networks on MAPK Signaling Pathways of Human Adipose-Derived Stem Cells in a Direct Current Electric Field., PMID:33204710
Neuronal activity regulates alternative exon usage., PMID:33172478