Catalog No.
DHD11501
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG4-lambda2
Clonality
Monoclonal
Target
CD116, CSF2R, GMR-alpha, CSF2RA, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, CSF2RY, GMCSFR-alpha, GM-CSF-R-alpha, CDw116
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P15509
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
CAM-3001, CAS: 1085337-57-0
Clone ID
Mavrilimumab
GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study, PMID: 32835256
Mavrilimumab: a unique insight and update on the current status in the treatment of rheumatoid arthritis, PMID: 31208237
Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis, PMID: 24648832
Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies, PMID: 32719685
Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody: Long-Term Safety and Efficacy in Patients With Rheumatoid Arthritis, PMID: 29361199
Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date, PMID: 28144129
Investigational therapies targeting the granulocyte macrophage colony-stimulating factor receptor-α in rheumatoid arthritis: focus on mavrilimumab, PMID: 29387176
Rheumatoid arthritis: Long-term mavrilimumab safe and effective, PMID: 29416133
Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy, PMID: 23094973
Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review, PMID: 33068263
Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis, PMID: 32033937
A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis, PMID: 28941039
Rheumatoid arthritis: new monoclonal antibodies, PMID: 29771256
Mavrilimumab for severe COVID-19, PMID: 33521662
Mavrilimumab for severe COVID-19, PMID: 33521661
Mavrilimumab for severe COVID-19 - Authors' reply, PMID: 33521663
Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis, PMID: 30358109
Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study, PMID: 21613310
Targeting Granulocyte-Monocyte Colony-Stimulating Factor Signaling in Rheumatoid Arthritis: Future Prospects, PMID: 31486005
Safety and Efficacy of Mavrilimumab For Rheumatoid Arthritis: A Systematic Review and Meta-Analysis, PMID: 33185165
Model-Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab, PMID: 28836356
Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis, PMID: 23234647
A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis, PMID: 28213566
Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review, PMID: 34409778
Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety, PMID: 24937321
Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial, PMID: 33754144
Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: findings from a Phase IIa study, PMID: 24720551
Comparison of the efficacy and safety of tofacitinib and mavrilimumab in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials, PMID: 33860755
Mechanistic modeling of antigen sink effect for mavrilimumab following intravenous administration in patients with rheumatoid arthritis, PMID: 21947370
Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis, PMID: 29069507
The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFRα-mAb treatment in rheumatoid arthritis patients, PMID: 30418117
Targeting GM-CSF in rheumatoid arthritis, PMID: 27586802
GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential, PMID: 25748625
GM-CSF as a therapeutic target in inflammatory diseases, PMID: 23933508
Innate and Adaptive Immunity in Giant Cell Arteritis, PMID: 33717054
Pulmonary pharmacodynamics of an anti-GM-CSFRα antibody enables therapeutic dosing that limits exposure in the lung, PMID: 27560702
Novel targeted therapies: the future of rheumatoid arthritis? Mavrilumab and tabalumab as examples, PMID: 23625979
Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma, PMID: 30649752
Market watch: Upcoming market catalysts in Q4 2015, PMID: 26338153
Quantitative measurement of the target-mediated internalization kinetics of biopharmaceuticals, PMID: 25208874
Giant cell arteritis: what is new in the preclinical and early clinical development pipeline?, PMID: 34106030
For research use only. Not for human or drug use.
