Catalog No.
YMD51701
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Lys617-Asp906
Predicted molecular weight
36.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P06802
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, E-NPP 1, Lymphocyte antigen 41, Ly-41, Phosphodiesterase I/nucleotide pyrophosphatase 1, Plasma-cell membrane glycoprotein PC-1, Alkaline phosphodiesterase I, 3.1.4.1, Nucleotide pyrophosphatase, NPPase, 3.6.1.9, Nucleotide diphosphatase, Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, Enpp1, Npps, Pc1, Pdnp1
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors., PMID:40465690
Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors., PMID:40410143
Recombinant ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) decreases vascular calcification and prevents osteomalacia in a rat model of chronic kidney disease., PMID:40390805
Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice., PMID:40324540
Extracellular NAD+ levels are associated with CD203a expression on Th17 cells and predict long-term recurrence-free survival in hepatocellular carcinoma., PMID:40107998
Enpp1 ameliorates MAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathway., PMID:39972484
Genetic association of MIR-449B, GCLC, eNOS, SORD, and ENPP1 with diabetic retinopathy., PMID:39952424
Multifaceted skeletal effects of sevelamer carbonate in a secondary hyperparathyroidism model., PMID:39918636
Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks., PMID:39872609
Base of Skull & Spinal Canal Narrowing in an Adolescent with Autosomal Recessive Hypophosphatemic Rickets Type 2., PMID:39751914
Homogeneous and bioluminescent biochemical and cellular assay for monitoring cGAMP and enzymes that generate and degrade cGAMP., PMID:39732796
Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA., PMID:39641818
Identification of a pancreatic juice-specific fluorescent probe through 411 probes activated by aminopeptidases/proteases or phosphatases/phosphodiesterases., PMID:39632145
Extracellular Vesicles Derived Ectonucleoside Triphosphate Diphosphohydrolase 3 Alleviates Mitochondrial Dysfunction of Osteoarthritis Chondrocytes via Ectonucleotide Pyrophosphatase/Phosphodiesterase 1-Induced Suppression of the AKT/Notch2 Pathway., PMID:39569601
Homozygous splice-site variant in ENPP1 underlies generalized arterial calcification of infancy., PMID:39538190
Elevated glucose levels increase vascular calcification risk by disrupting extracellular pyrophosphate metabolism., PMID:39529124
A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction., PMID:39454569
Biology of bone mineralization and ectopic calcifications: the same actors for different plays., PMID:39343471
Autosomal recessive hypophosphatemic rickets type 2 due to ENPP1 deficiency (ARHR2)., PMID:39343470
Generalized Arterial Calcification of Infancy (GACI)., PMID:39343469
Novel treatment for PXE: Recombinant ENPP1 enzyme therapy., PMID:39342427
Identifying compound-protein interactions with knowledge graph embedding of perturbation transcriptomics., PMID:39303708
Epitranscriptomic regulation of lipid oxidation and liver fibrosis via ENPP1 mRNA m6A modification., PMID:39249529
Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging., PMID:39212714
ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in human epidermal growth factor receptor 2-positive breast cancer., PMID:39210244
A high-calcium environment induced ectopic calcification of renal interstitial fibroblasts via TFPI-2-DCHS1-ALP/ENPP1 axis to participate in Randall's plaque formation., PMID:39196305
ENPP1 enzyme replacement therapy improves ectopic calcification but does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia., PMID:39165910
Vascular calcification in chronic kidney disease associated with pathogenic variants in ABCC6., PMID:38944164
Potential of dapagliflozin to prevent vascular remodeling in the rat carotid artery following balloon injury., PMID:38879387
ATP-elicited Cation Fluxes Promote Volume-regulated Anion Channel LRRC8/VRAC Transport cGAMP for Antitumor Immunity., PMID:38847616
Genetic polymorphisms of inflammatory and bone metabolism related proteins in a population with dental implants of the Basque Country. A case-control study., PMID:38840172
Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint., PMID:38749434
Stimulating STING for cancer therapy: Taking the extracellular route., PMID:38723635
Selected markers of ovarian cancer and their relation to targeted therapy (Review)., PMID:38628658
TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation., PMID:38582229
Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors., PMID:38531526
Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS-STING Signaling., PMID:38498770
Transcriptome Analysis Identifies Tumor Immune Microenvironment Signaling Networks Supporting Metastatic Castration-Resistant Prostate Cancer., PMID:38435029
Bone Marrow-Derived ABCC6 Is an Essential Regulator of Ectopic Calcification In Pseudoxanthoma Elasticum., PMID:38367909
The use of burosumab to treat autosomal-recessive hypophosphatemic rickets type 2: rationale and a first clinical experience., PMID:38308754
ENPP1 inhibits the transcription activity of the hepatitis B virus pregenomic promoter by upregulating the acetylation of LMNB1., PMID:38265511
Identification of extracellular membrane protein ENPP3 as a major cGAMP hydrolase, cementing cGAMP's role as an immunotransmitter., PMID:38260585
Targeting ENPP1 depletion may be a promising therapeutic strategy for treating oral squamous cell carcinoma via cytotoxic autophagy-related apoptosis., PMID:38231531
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression., PMID:38177693
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer., PMID:38117852
Identification of a DBA/2 Mouse Sub-strain as a Model for Pseudoxanthoma Elasticum-Like Tissue Calcification., PMID:38044132
Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice., PMID:38042486
Small molecule inhibitors for cancer immunotherapy and associated biomarkers - the current status., PMID:38022587
Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study., PMID:37900947
ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats., PMID:37814911
For research use only. Not for human or drug use.
