Catalog No.
YMA55401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Lys251-Thr481
Predicted molecular weight
28.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O35732
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, CASP8 and FADD-like apoptosis regulator subunit p43, CASP8 and FADD-like apoptosis regulator subunit p12, Cflar, Cash
ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D., PMID:40440066
Computational and Experimental Study of the Conformational Variation of the Catalytic Residue His41 of the SARS-CoV-2 Main Protease., PMID:40387138
The lip flip: a systematic review of botulinum toxin lip augmentation., PMID:40377719
Changes in the Aqueous Solvent do not Impact the Internal Ring-Flip Dynamic of Fully Buried F52 in Protein GB1., PMID:40375829
The histone deacetylase inhibitor CT-101 flips the switch to fetal hemoglobin expression in sickle cell disease mice., PMID:40359410
Lipid Scrambling Pathways in the Sec61 Translocon Complex., PMID:40325981
The impact of subunit type, alternative splicing, and auxiliary proteins on AMPA receptor trafficking., PMID:40316023
Xanthatin induces apoptosis through ROS-mediated c-FLIP inhibition in human retinoblastoma cells., PMID:40309730
Comprehensive Insights into the Cholesterol-Mediated Modulation of Membrane Function through Molecular Dynamics Simulations., PMID:40297234
NMR-Based Rational Drug Design of G:G Mismatch DNA Binding Ligand Trapping Transient Complex via Disruption of a Key Allosteric Interaction., PMID:40245052
The P4-phospholipid flippase Atp11a is required for maintenance of eye and ear structure in zebrafish., PMID:40223426
FLIPL permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization., PMID:40203042
Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy., PMID:40198752
A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site in Schistosoma mansoni., PMID:40161785
Genome-wide identification of the P4ATPase gene family and its response to biotic and abiotic stress in soybean (Glycine max L.)., PMID:40114086
Synergistic effects of hydrophilic residues in the transmembrane region on lipid scrambling activity of dimeric helices., PMID:40086211
The 'very moment' when UDG recognizes a flipped-out uracil base in dsDNA., PMID:40055399
HAP/ClpP-mediated disaggregation and degradation of Mutant SOD1 aggregates: A potential therapeutic strategy for Amyotrophic lateral sclerosis (ALS)., PMID:40054065
The crystal structures of apo and tryptophan-bound tryptophanyl-tRNA synthetase from Neisseria gonorrhoeae., PMID:40023769
IL6 mediated cFLIP downregulation increases the migratory and invasive potential of triple negative breast cancer cell., PMID:39988287
Lip Filler Versus "Lip Flip": Longitudinal Public Interest and a Brief Review of Literature., PMID:39936357
A gate-clamp mechanism for ssDNA translocation by DdmD in Vibrio cholerae plasmid defense., PMID:39907109
Novel fixed-target serial crystallography flip-holder for macromolecular crystallography beamlines at synchrotron radiation sources., PMID:39899406
Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with 'persister' cell profiles fail to benefit from adjuvant chemotherapy., PMID:39886119
Electrophysiological Characterization of Monoolein-Fatty Acid Bilayers., PMID:39865883
c-FLIP/Ku70 complex; A potential molecular target for apoptosis induction in hepatocellular carcinoma., PMID:39818348
Gymnema saponin-induced lipid flip-flop identifies rigid membrane phenotype of methicillin resistant S. aureus and enhances it's antibiotic susceptibility., PMID:39805384
Nano-viscosimetry analysis of membrane disrupting peptide magainin2 interactions with model membranes., PMID:39798207
Extensive homologous recombination safeguards oocyte genome integrity in mammals., PMID:39797737
Benchmarking uncertainty quantification for protein engineering., PMID:39775201
Spontaneous base flipping helps drive Nsp15's preferences in double stranded RNA substrates., PMID:39755678
Pharmacological targeting of caspase-8/c-FLIPL heterodimer enhances complex II assembly and elimination of pancreatic cancer cells., PMID:39753884
Helicobacter Pylori-induced BRD2 m6A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis., PMID:39744419
Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway., PMID:39736469
How Do Variants of Residues in the First Coordination Sphere, Second Coordination Sphere, and Remote Areas Influence the Catalytic Mechanism of Non-Heme Fe(II)/2-Oxoglutarate Dependent Ethylene-Forming Enzyme?, PMID:39722885
Contributing factors to the oxidation-induced mutational landscape in human cells., PMID:39715760
Conformational dynamics of a nicotinic receptor neurotransmitter site., PMID:39693137
G-Protein-Coupled Receptor Surface Creates a Favorable Pathway for Membrane Permeation of Drug Molecules., PMID:39688267
The C-terminal activating domain promotes pannexin 1 channel opening., PMID:39671183
Budding of Asymmetric Lipid Bilayers: Effects of Cholesterol, Anionic Lipid, and Electric Field., PMID:39670354
Trp residues near peptide termini enhance the membranolytic activity of cationic amphipathic α-helices., PMID:39657392
Investigating the Origin of Automatic Rhodopsin Modeling Outliers Using the Microbial Gloeobacter Rhodopsin as Testbed., PMID:39655718
The utility of small nutation angle 1H pulses for NMR studies of methyl-containing side-chain dynamics in proteins., PMID:39645350
Co-Translational Deposition of N6-Acetyl-L-Lysine in Nascent Proteins Contributes to the Acetylome in Mammalian Cells., PMID:39630081
RNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in c-Flip Knockdown Mice., PMID:39599827
Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate., PMID:39547906
Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis., PMID:39520684
Nucleosome flipping drives kinetic proofreading and processivity by SWR1., PMID:39506114
Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer., PMID:39505147
Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles., PMID:39477986
For research use only. Not for human or drug use.
