Catalog No.
YHN52701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln198-Gly380
Predicted molecular weight
23.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NQV7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone-lysine N-methyltransferase PRDM9, PR domain zinc finger protein 9, PR domain-containing protein 9, Protein-lysine N-methyltransferase PRDM9, 2.1.1.-, [histone H3]-lysine36 N-trimethyltransferase PRDM9, 2.1.1.359, [histone H3]-lysine4 N-trimethyltransferase PRDM9, 2.1.1.354, [histone H3]-lysine9 N-trimethyltransferase PRDM9, 2.1.1.355, [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9, 2.1.1.362, [histone H4]-lysine20 N-methyltransferase PRDM9, 2.1.1.361, PRDM9, PFM6
Investigation and design of the dual specificity of the PRDM9 protein lysine methyltransferase., PMID:40442378
Phenogenomic resources immortalized in a panel of wild-derived strains of five species of house mice., PMID:40199997
Epigenetic Regulation of CD8+ Effector T Cell Differentiation by PDCD5., PMID:40111008
Exploring the genetic mechanisms driving KIR diversification., PMID:40096639
Ribosomal DNA arrays are the most H-DNA rich element in the human genome., PMID:40041207
Characterization of PRDM9 Multifunctionality in Yak Testes Through Protein Interaction Mapping., PMID:40003887
Maternal PRDM10 activates essential genes for oocyte-to-embryo transition., PMID:39994175
Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis., PMID:39928879
PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish., PMID:39761307
Multiple losses of aKRAB from PRDM9 coincide with a teleost-specific intron size distribution., PMID:39604973
A Minimal Hybrid Sterility Genome Assembled by Chromosome Swapping Between Mouse Subspecies (Mus musculus)., PMID:39404090
Dynamic Changes in Histone Modifications Are Associated with Differential Chromatin Interactions., PMID:39202349
Creating Meiotic Recombination-Regulating DNA Sites by SpEDIT in Fission Yeast Reveals Inefficiencies, Target-Site Duplications, and Ectopic Insertions., PMID:39199403
The GC-content at the 5' ends of human protein-coding genes is undergoing mutational decay., PMID:39138526
High prevalence of PRDM9-independent recombination hotspots in placental mammals., PMID:38809707
Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis: A model based exploration of the PRDM9 intra-genomic Red Queen., PMID:38768268
Principles of chromosome organization for meiotic recombination., PMID:38657614
Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression., PMID:38566223
Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features., PMID:38386752
Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice., PMID:38217871
Novel Insights into the Landscape of Crossover and Noncrossover Events in Rhesus Macaques (Macaca mulatta)., PMID:38051960
Cancer Associated PRDM9: Implications for Linking Genomic Instability and Meiotic Recombination., PMID:38003713
Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence., PMID:37830496
Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer's Disease., PMID:37759801
Take a walk on the KRAB side., PMID:37716846
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells., PMID:37608663
Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features., PMID:37502971
The Recombination Hotspot Paradox: Co-evolution between PRDM9 and its target sites., PMID:37451508
Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis., PMID:37162821
Meiotic Recognition of Evolutionarily Diverged Homologs: Chromosomal Hybrid Sterility Revisited., PMID:37030001
Identification of nonhistone substrates of the lysine methyltransferase PRDM9., PMID:36972790
The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots., PMID:36967403
A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3)., PMID:36754567
Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients., PMID:36688188
Orchestrating recombination initiation in mice and men., PMID:36681473
Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15., PMID:36674842
Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse (Mus musculus) Populations., PMID:36508360
Decorating chromatin for enhanced genome editing using CRISPR-Cas9., PMID:36459645
Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes., PMID:36198798
Systems-level identification of key transcription factors in immune cell specification., PMID:36156073
The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots., PMID:36068616
Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus)., PMID:35924978
Chromatin accessibility shapes meiotic recombination in mouse primordial germ cells through assisting double-strand breaks and loop formation., PMID:35870788
Rapid divergence of a gamete recognition gene promoted macroevolution of Eutheria., PMID:35821049
Assessing the Immune Cell Subset and Genetic Mutations in Patients With Palindromic Rheumatism Seronegative for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide., PMID:35819819
Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution., PMID:35812747
Prdm9 deficiency of rat oocytes causes synapsis among non-homologous chromosomes and aneuploidy., PMID:35596034
Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas., PMID:35522148
ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression., PMID:35320728
Evolution of the recombination regulator PRDM9 in minke whales., PMID:35296233
For research use only. Not for human or drug use.
